Navigation Links
Zombie cancer cells eat themselves to live
Date:4/5/2014

A University of Colorado Cancer Center study recently published in the journal Cell Reports and presented today at the American Association for Cancer Research (AACR) Annual Conference 2014 shows that the cellular process of autophagy in which cells "eat" parts of themselves in times of stress may allow cancer cells to recover and divide rather than die when faced with chemotherapies.

Autophagy, from the Greek "to eat oneself," is a process of cellular recycling in which cell organelles called autophagosomes encapsulate extra or dangerous material and transport it to the cell's lysosomes for disposable. Like tearing apart a Lego kit, autophagy breaks down unneeded cellular components into building blocks of energy or proteins for use in surviving times of low energy or staying safe from poisons and pathogens (among other uses).

"What we showed is that if this mechanism doesn't work right, for example if autophagy is too high or if the target regulated by autophagy isn't around, cancer cells may be able to rescue themselves from death caused by chemotherapies," says Andrew Thorburn, PhD, deputy director of the CU Cancer Center.

A movie that accompanies the study online shows a cancer cell dying. In the first few frames, mitochondrial cell walls break down and the cell's mitochondria can be seen releasing proteins in a process abbreviated as MOMP, which is considered a common marker of cell death. But then high autophagy allows the cell to encapsulate and "digest" these released proteins before MOMP can keep the cell well and truly dead. Later in the movie, the cancer cell recovers and goes on to divide.

"The implication here is that if you inhibit autophagy you'd make this less likely to happen, i.e. when you kill cancer cells they would stay dead," Thorburn says.

Thorburn and colleagues including postdoctoral researcher Jacob Gump, PhD, show that autophagy depends on the target PUMA to regulate cell death. Specifi
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Want to survive the zombie apocalypse? This cologne could be the key (video)
2. Sleep may stop chronic pain sufferers from becoming zombies
3. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
4. Embryonic development protein active in cancer growth
5. BRG1 mutations confer resistance to hormones in lung cancer
6. Genetic variation in East Asians found to explain resistance to cancer drugs
7. Beyond the microscope: Identifying specific cancers using molecular analysis
8. Marshall University study may lead to new treatments for prostate cancer
9. Salk scientists open new window into how cancers override cellular growth controls
10. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
11. Genetic abnormality offers diagnostic hope for childrens cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... cognitive function may play roles in one,s musical aptitude, ... timbre, tone durations, and formal structure in music. , ... that extremes in musical aptitude (extreme capacity/no capacity) are ... having moderate aptitude. , "This is a typical feature ... and it is influenced to varying degrees by environmental ...
(Date:9/15/2014)... is no published account where hippopotamuses are demonstrably shown ... of water. But if they can,t swim, how did ... widely accepted models for the methods, patterns, and timing ... Cyprus, Crete, and Madagascar) may need to be reconsidered. ... the mainland are not currently supported by positive ...
(Date:9/15/2014)... is available in German . ... is straightforward: it doubles, divides in the middle and ... long assumed that cells of the same kind are ... Bulgheresi,s team, University of Vienna, revealed that two non-model ... perceivable by the naked eye. These findings have been ...
Breaking Biology News(10 mins):Think big! Bacteria breach cell division size limit 2
... A new study suggests that jewel scarab beetles find ... that creates the 3D effects for the blockbuster movie ... Texas, the jewel scarab species Chrysina gloriosa ... ability could provide the beetles with a tremendous advantage, ...
... Lovn Centre for Marine Sciences at the University of Gothenburg ... in the Gullmarsfjord north of Gothenburg. The bacterium has been ... marine research center. Researcher Matthias Obst from the ... at the Sven Lovn Centre for Marine Sciences, a new ...
... Boston, MA A tobacco company,s new, dissolvable ... but which in some cases resembles popular candies--could lead ... new study from the Harvard School of Public Health ... for Disease Control and Prevention (CDC) and the Food ...
Cached Biology News:Beetles stand out using 'Avatar' tech 2Tobacco company's new, dissolvable nicotine products could lead to accidental poisoning 2
(Date:9/12/2014)... On Thursday, September 11, 2014, the NASDAQ Composite ... finished the day 0.12% lower at 17,049.00, and the S&P ... based as seven out of ten sectors ended the session ... the day at 741.83, down 0.33%, while the index has ... coverage on the following equities: Exelixis Inc. (NASDAQ: ...
(Date:9/11/2014)... RURO, Inc., a leading laboratory ... and sample management solutions provider, announces the release ... on the most recent version of its Limfinity® ... seen mass adoption, especially from multi-license environment customers. ... brought an entirely new User Interface and version ...
(Date:9/11/2014)... Lab researchers believes it has uncovered the secret ... layers of transition metal dichalcogenide (TMDC) materials, the ... and photonic applications. , Using two-photon excitation ... one of the most promising of 2D materials, ... dark states energy states in which single ...
(Date:9/11/2014)... one atom thick sheet of carbon, can be randomly ... of graphene that could have a significant impact on ... it could provide an ultra-strong, non-corrosive coating for a ... solutions can be used to paint various surfaces ranging ... a simple chemical treatment, the resulting coatings behave like ...
Breaking Biology Technology:Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 4Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 5Limfinity® Version 5.1 Available 2Excitonic dark states shed light on TMDC atomic layers 2Excitonic dark states shed light on TMDC atomic layers 3Graphene paints a corrosion-free future 2
... Stock for Rights to Spinal Cells in Future, ... (Amex: CUR ), announces that Korean conglomerate, CJ,CheilJedang ... for the exclusive license to Neuralstem,s stem cell-products and,technology ... part of the agreement, CJ has purchased $2.5 million ...
... will support Phase 3 Trials for Crohn,s Disease, Pouchitis and ... ... 20 Ocera Therapeutics, a,biopharmaceutical company focused on the licensing, ... of,gastrointestinal and liver diseases, has announced the completion of a,$35.5 ...
... Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: NTII ), today ... Pharmaceuticals GmbH (Merz) for sales,by Merz and its ... Alzheimer,s disease for the quarter ended September 30,2007. ... royalty payments on sales of Memantine by Merz ...
Cached Biology Technology:Neuralstem Inc. Announces Strategic Investment by Korean CJ CheilJedang Corporation 2Neuralstem Inc. Announces Strategic Investment by Korean CJ CheilJedang Corporation 3Ocera Therapeutics Closes $35.5 Million Series C Financing 2Ocera Therapeutics Closes $35.5 Million Series C Financing 3Neurobiological Technologies Reports $2.1 Million Quarterly Payment for Sales of Memantine 2
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
Mouse monoclonal [CIG 3A11/5] to Cig2 (rating: *****) ( Abpromise for all tested applications)....
Rabbit polyclonal to CAMK 1D beta ( Abpromise for all tested applications). entrezGeneID: 57118 SwissProtID: Q5SQQ7...
Biology Products: