Navigation Links
Zombie cancer cells eat themselves to live
Date:4/5/2014

A University of Colorado Cancer Center study recently published in the journal Cell Reports and presented today at the American Association for Cancer Research (AACR) Annual Conference 2014 shows that the cellular process of autophagy in which cells "eat" parts of themselves in times of stress may allow cancer cells to recover and divide rather than die when faced with chemotherapies.

Autophagy, from the Greek "to eat oneself," is a process of cellular recycling in which cell organelles called autophagosomes encapsulate extra or dangerous material and transport it to the cell's lysosomes for disposable. Like tearing apart a Lego kit, autophagy breaks down unneeded cellular components into building blocks of energy or proteins for use in surviving times of low energy or staying safe from poisons and pathogens (among other uses).

"What we showed is that if this mechanism doesn't work right, for example if autophagy is too high or if the target regulated by autophagy isn't around, cancer cells may be able to rescue themselves from death caused by chemotherapies," says Andrew Thorburn, PhD, deputy director of the CU Cancer Center.

A movie that accompanies the study online shows a cancer cell dying. In the first few frames, mitochondrial cell walls break down and the cell's mitochondria can be seen releasing proteins in a process abbreviated as MOMP, which is considered a common marker of cell death. But then high autophagy allows the cell to encapsulate and "digest" these released proteins before MOMP can keep the cell well and truly dead. Later in the movie, the cancer cell recovers and goes on to divide.

"The implication here is that if you inhibit autophagy you'd make this less likely to happen, i.e. when you kill cancer cells they would stay dead," Thorburn says.

Thorburn and colleagues including postdoctoral researcher Jacob Gump, PhD, show that autophagy depends on the target PUMA to regulate cell death. Specifi
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Want to survive the zombie apocalypse? This cologne could be the key (video)
2. Sleep may stop chronic pain sufferers from becoming zombies
3. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
4. Embryonic development protein active in cancer growth
5. BRG1 mutations confer resistance to hormones in lung cancer
6. Genetic variation in East Asians found to explain resistance to cancer drugs
7. Beyond the microscope: Identifying specific cancers using molecular analysis
8. Marshall University study may lead to new treatments for prostate cancer
9. Salk scientists open new window into how cancers override cellular growth controls
10. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
11. Genetic abnormality offers diagnostic hope for childrens cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... promise for treating damaged organs and tissues, but with ... their effectiveness. New methods are being developed and tested ... after transplantation, as described in a Review article in ... Mary Ann Liebert, Inc., publishers. The article is available ... website . , In the article ,Preconditioning ...
(Date:7/22/2014)... Cambridge, MA and Shenzhen, China July 22, ... Tech), a subsidiary of BGI, the world,s largest ... a new human whole exome sequencing service based ... service includes in-depth bioinformatics analysis and SNP validation, ... 31, 2014. , Complete Genomics, highly regarded ...
(Date:7/22/2014)... a place emerging as a world-famous vacation spot with natural ... on the island. The Korea Institute of Geoscience and Mineral ... that a recent volcanic eruption was evident 5,000 years ago. ... date when lava spewed out of a volcano 5,000 years ... as the one the whole peninsula. , The research team ...
Breaking Biology News(10 mins):BGI Tech launches human whole exome sequencing service on complete genomics' advanced platform 2Jeju Island is a live volcano 2
... case state-of-the-art energy efficient housing will be officially opened ... Nottingham. The house built by BASF, a major ... part of the Creative Energy Homes Project on University ... of Built Environment to stimulate sustainable design ideas and ...
... Heritage Foundation (CHF) announced that Leroy Hood ... Award. Jointly sponsored by the Pittsburgh Conference ... and CHF, this award recognizes outstanding individuals ... community, inspired achievement, promoted public understanding of ...
... Ala. The long-sought-after biological gateway that anthrax uses ... at the University of Alabama at Birmingham (UAB). ... a receptor that sits on the surface of certain ... exactly how the bacteria get inside cells to begin ...
Cached Biology News:Opening day for a home of the future 2Opening day for a home of the future 3Leroy Hood to receive 2008 Pittcon Heritage Award 2Leroy Hood to receive 2008 Pittcon Heritage Award 3Anthrax cellular entry point uncovered 2
(Date:7/22/2014)... Dr. Williams says, “Bush has joined the ... the greatest health care system in the world is ... while trying to serve the public. Unfortunately, Bush has ... an enormous system that none of them can first ... series of Open Letters ( http://is.gd/wdU2CM ) provides a ...
(Date:7/21/2014)... July 21, 2014 With a ... programming, the new Cole-Parmer® Digital Gear Pump ... easy to operate for automated process applications. , ... dispensing. The batch count function counts down and ... totalizer tracks amount dispensed across multiple cycles. View ...
(Date:7/21/2014)... chemist in Syracuse University,s College of Arts and ... the synthesis of stainless nanoparticles. , Mathew M. ... a three-year, $360,000 grant from the National Science ... with metal stainless alloy nanostructures, the results of ... rechargeable lithium-ion batteries. , Maye,s approach ...
(Date:7/21/2014)... PHILADELPHIA , July 21, 2014  Mike ... closing of $1.6 million in Series Seed B ... and chemical sensors for the life science, defense, ... Trimaran Capital Partners led the round and was ... 36 Angels.  Said Patterson , "This round ...
Breaking Biology Technology:Dr. Ira Williams Asks What’s Wrong With Jonathan Bush’s Book, Where Does It Hurt? 2New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Syracuse University chemist to use NSF grant to study materials chemistry, nanoscience 2Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2
... Jan. 30 Monogram,Biosciences, Inc., (Nasdaq: MGRM ) ... February 7, 2008 at 4:30 p.m. (Eastern Time) to ... outlook for 2008.,The call will be hosted by Mr. ... participate in the live teleconference, please call (877) 545-1409,or ...
... Helix BioPharma Corp. (TSX: HBP / Frankfurt: WKN ... Helix BioPharma Corp.,announces that at the Company,s Annual ... all of the resolutions presented by,management, appointing KPMG ... Cawkell, Jack Kay, Slawomir Majewski, and Gordon Lickrish ...
... 30 In a letter to,Governor Jennifer Granholm ... the Governor,s State of the State Address,wherein she ... MichBio is the,statewide association for Michigan,s life sciences ... of the legislature, to diversify,the state,s economy by ...
Cached Biology Technology:Monogram Biosciences Announces Fourth Quarter 2007 Financial Results Conference Call 2Helix BioPharma shareholders vote in favour of management 2MichBio Responds to Governor's Plan to Repeal Tort Reform Laws 2
...
Mynox is intended for research use only. Mynox is used for the elimination of Mycoplasma and Acholeplasma in cell and virus cultures, and other biologicals....
... Acridinium NHS ester can be ... nucleic acids. The covalently bound ... chemiluminescence in the presence of ... proteins can be used as ...
... The electrophoretic mobility shift assay (EMSA) is ... Often referred to as gel shift or ... the principle that when subjected to electrophoresis, ... DNA-protein complex. The Pierce LightShift Chemiluminescent EMSA ...
Biology Products: