Navigation Links
Zinc, proteins, and an essential cellular balancing act
Date:9/30/2013

es that damage proteins, but it also has this totally distinct chaperone function that protects proteins from aggregating. We found that the chaperone function was the more important of the two."

"In yeast, if a cell is deficient in zinc, the proteins can mis-fold, and Tsa1 is needed to keep the proteins intact so they can function," says Eide, a professor of nutritional science. "If you don't have zinc, and you don't have Tsa1, the proteins will glom together into big aggregations that are either toxic by themselves, or toxic because the proteins are not doing what they are supposed to do. Either way, you end up killing the cell."

While the medical implications remain to be explored, there are clear similarities between yeast and human cells. "Zinc is needed by all cells, all organisms, it's not just for steel roofs, nails and trashcans," Eide says. "The global extent of zinc deficiency is debated, but diets that are high in whole grains and low in meat could lead to deficiency."

If low zinc supply has the same effect on human cells as on yeast, zinc deficiency might contribute to human diseases that are associated with a build-up of "junked" proteins, such as Parkinson's and Alzheimer's. Eide says a similar protective system to Tsa1 also exists in animals, and the research group plans to move ahead by studying that system in human cell culture.


'/>"/>

Contact: Colin MacDiarmid
macdiarmid@nutrisci.wisc.edu
608-262-1118
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Immune system fighters speak in patterns of proteins, prefer squishy partners
2. Juniper essential oil characteristics determined
3. Protein targeted for cancer drug development is essential for normal heart function
4. Animated Essential Atlas of Anatomoy and Physiology Anatomy Atlas
5. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
6. CNIO researchers identify a new gene that is essential for nuclear reprogramming
7. Study points to essential role of IL-22 in lung repair after the flu
8. Sex and gender competency essential to medical care
9. Essential informatics methods and tools for analyzing the explosion of NGS data
10. Scientists discover structure of protein essential for quality control, nerve function
11. Nature study reveals loss of essential blood cell gene leads to anemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... --  News Highlights: , ... Partners Data Lake, an agile data and analytics ... allow researcher and clinicians to explore and develop ... of patients , The Partners Data Lake ... Partners system, breaking down physical barriers for collaboration ...
(Date:11/18/2014)... YORK , Nov. 18, 2014   ... identity authentication solutions, and MorphoTrust USA ... and services, today announced a strategic partnership to ... enterprise, motor vehicle administration (MVA), airport screening and ... in identity-related solutions, MorphoTrust serves consumers through a ...
(Date:11/12/2014)... 12, 2014 Crossmatch™, a leading provider of ... ® fingerprint readers have been deployed throughout Montparnasse ... Central Mexico . The bakery chain implemented the ... issues caused by employees clocking in for each other. ... readers, Montparnasse relied on paper timecards and a mechanical ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... Paul the Octopusthe eight-legged oracle who made international ... talented cephalopod in the sea. The Indonesian mimic octopus, ... potential predators, may well give Paul a run for ... By creatively configuring its limbs, adopting characteristic undulating movements, ...
... biology of a gecko,s sticky foot to create a robot ... scale a wall of slick glass, the Stickybot can climb ... gecko toes. , Mark Cutkosky, the lead designer of the ... Center for Design Research, has been collaborating with scientists around ...
... is urgently needed in Northern Ireland to ensure the ... researchers at Queen,s University Belfast. Lizards are found ... but a Queen,s study, published in international journal ... been replaced through agricultural intensification. "The fact that ...
Cached Biology News:Octopus mimics flatfish and flaunts it 2Octopus mimics flatfish and flaunts it 3Secrets of the gecko foot help robot climb 2Secrets of the gecko foot help robot climb 3No lounge for local lizards as living room vanishes 2
(Date:12/13/2014)... USA, and TAICHUNG, Taiwan (PRWEB) December 12, 2014 ... despite less rosy indicators in overall global economic growth, ... for optics and photonics , said in a featured ... Conference) on 5 December at the National Chung Hsing ... energy, which is being integrated into future energy supplies ...
(Date:12/13/2014)... December 13, 2014 According to population ... people between now and 2030." If a population explosion ... seventh most populous state in the country. , To ... at the Future of North Carolina Forum on December ... we have the necessary infrastructure in place? Enough clean ...
(Date:12/13/2014)... , Dec. 12, 2014  Vermillion, Inc. (NasdaqCM: VRML), ... today the appointments of Veronica G. H. Jordan ... the Company,s Board of Directors, bringing the total number ... Jim LaFrance , Chairman, President, ... tremendously pleased to announce the appointments of Veronica and ...
(Date:12/13/2014)... N.Y. , Dec. 12, 2014 /PRNewswire/ ... in the discovery and development of therapeutic ... diseases, today announced publication of a manuscript ... and inhibits remyelination in neurodegenerative disease" in ... Neurobiology of Disease*.  The publication highlights an ...
Breaking Biology Technology:Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5North Carolina Chamber of Commerce: Asking Questions & Gathering Answers with a Futurist 2Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 2Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 3Vaccinex announces publication of preclinical studies with an anti-SEMA4D antibody in animal models of neuroinflammatory and demyelinating disease 2
... MultiCell,Technologies, Inc. (OTC Bulletin Board: MCET) has moved into new ... May 1, 2008:, -- the new address is: ... RI 02895. -- new phone number is: ... (401) 762-0098, MultiCell Technologies, Inc. is a biopharmaceutical company ...
... to announce that,Grace Ju, Ph.D., research director, RNA Therapeutics ... of Science" by the New Jersey,Association of Biomedical Research ... held May 1 at the Bridgewater Manor., Dr. ... event, which is also,marking the 20th anniversary of NJABR, ...
... Company with 3 divisions has exciting new and unique products; ... contracts to be announced in near future ..., BOCA ... "Company") announced today that their stock is now,up and trading on ... Filings are complete at PinkSheets.com. From this point,Solei will continue on ...
Cached Biology Technology:MultiCell Technologies Relocates Corporate Headquarters 2Roche Research Director Grace Ju Hailed as NJABR 'Outstanding Woman of Science' 2Roche Research Director Grace Ju Hailed as NJABR 'Outstanding Woman of Science' 3Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 2Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 3Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 4
Screening test for the detection of Salmonella sp. by means of DNA amplification, subsequent molecular hybridization and detection on a microtitre plate....
... three step procedure (PCR, Exonuclease III digestion ... one day. The typical cloning efficiency using ... Features and Benefits: , , Universal - ... expression vector , High Cloning Efficiency - ...
... or 384-well PCR plates Dimples on both sides ... plates End tabs on Thermo-Mat™ 384 fit into ... sealing is achieved with either Thermo-Mat™ 96 or 384 ... lid thermal cyclers Fully autoclavable May ...
... HistoMark Biotin Streptavidin-HRP Systems provide rapid, ... intracellular antigens in frozen or paraffin-embedded ... These systems also facilitate double or ... be performed simultaneously with primary antibodies ...
Biology Products: