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Zinc, proteins, and an essential cellular balancing act
Date:9/30/2013

es that damage proteins, but it also has this totally distinct chaperone function that protects proteins from aggregating. We found that the chaperone function was the more important of the two."

"In yeast, if a cell is deficient in zinc, the proteins can mis-fold, and Tsa1 is needed to keep the proteins intact so they can function," says Eide, a professor of nutritional science. "If you don't have zinc, and you don't have Tsa1, the proteins will glom together into big aggregations that are either toxic by themselves, or toxic because the proteins are not doing what they are supposed to do. Either way, you end up killing the cell."

While the medical implications remain to be explored, there are clear similarities between yeast and human cells. "Zinc is needed by all cells, all organisms, it's not just for steel roofs, nails and trashcans," Eide says. "The global extent of zinc deficiency is debated, but diets that are high in whole grains and low in meat could lead to deficiency."

If low zinc supply has the same effect on human cells as on yeast, zinc deficiency might contribute to human diseases that are associated with a build-up of "junked" proteins, such as Parkinson's and Alzheimer's. Eide says a similar protective system to Tsa1 also exists in animals, and the research group plans to move ahead by studying that system in human cell culture.


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Contact: Colin MacDiarmid
macdiarmid@nutrisci.wisc.edu
608-262-1118
University of Wisconsin-Madison
Source:Eurekalert

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