Navigation Links
Zebrafish swim into drug development
Date:1/21/2010

patterning and some only affected angiogenesis," Hong said. The investigators biochemically characterized compounds of both types and found very selective and potent BMP inhibitors and selective VEGF inhibitors.

The zebrafish embryo, Hong said, is very good at assessing a compound's selectivity for a certain signaling pathway. Mixed signals from compounds that are not selective (they hit multiple targets) are toxic to the embryo it "shuts down development."

The team identified a VEGF inhibitor, for example, that outperformed an existing VEGF inhibitor that was being developed for cancer therapy (blocking angiogenesis cuts off the "supply lines" for a growing tumor) but was pulled from development during a Phase III trial.

"If they (the pharmaceutical company) had tested that compound in zebrafish, they would have quickly learned that it wasn't potent or selective," Hong said.

"Using zebrafish is a novel way to do a structure-activity relationship study" a study that examines a series of analog compounds to determine which is the most selective and most potent, he added.

Traditionally, pharmaceutical companies perform these types of studies in vitro, with isolated proteins or cells. But Hong points out that in vitro studies assess only "one dimension" of the biology. Compounds that have great activity in vitro often fail later because they have poor selectivity or because they do not have chemical properties that make them good drugs (they are not "bioavailable").

"The zebrafish assesses selectivity and bioavailability all at the same time," Hong says. "What the traditional approach takes months to do, the zebrafish does in a day."

Because BMP and VEGF inhibitors have therapeutic potential for a variety of diseases, the investigators will begin to test the drug candidates in mouse models.

Hong praised Vanderbilt leaders for putting into place the drug discovery infrastructure that made the wor
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Drug-proof zebrafish reveal secrets of addiction
2. Pitt team finds molecule that regulates heart size by using zebrafish screening model
3. Zebrafish provide a model for cancerous melanoma in humans
4. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
5. AZTI-Tecnalia coordinates a platform promoting the use of zebrafish in scientific research
6. NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
7. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
8. Deadly genetic disease prevented before birth in zebrafish
9. A screening strategy using zebrafish targets genes that protect against hearing loss
10. Study shows how the zebrafish gets his stripe
11. Zebrafish to shed light on human mitochondrial diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... that an expansion of marine protected areas is needed ... According to investigators from the Wildlife Conservation Society ... focused on saving the largest numbers of species, often ... and difficult-to-replace ecological functions. , Many vital ... species that also are food for millions of people. ...
(Date:8/28/2014)... E-cigarettes are healthier for your neighbors than traditional ... according to a new study from USC. , ... overall 10-fold decrease in exposure to harmful particles, ... of exposure to some harmful metals in second-hand ... , While tobacco smoke contains high levels of ...
(Date:8/28/2014)... ROCHESTER, Minn. A Mayo Clinic researcher and his ... speed up and enhance the process of re-engineering cells ... that uses network biology methods to aid stem cell ... cell engineering are described in two back-to-back papers in ... has a broad range of uses for all types ...
Breaking Biology News(10 mins):Study finds marine protected areas inadequate for protecting fish and ocean ecology 2Second-hand e-cig smoke compared to regular cigarette smoke 2New tool aids stem cell engineering for medical research 2
... motor excitability have a better working memory than humans with ... by scientists from the Transfacultary Research Platform at the University ... drawn as to the general cortical excitability as well ... temporary storage of information such as memorizing a phone number ...
... found new clues to how plants evolved to withstand wintry ... issue of the journal Nature , the team constructed ... plants the largest time-scaled evolutionary tree to date. By ... stem data for thousands of species, the researchers were able ...
... The Scripps Research Institute (TSRI) have demonstrated a drug-discovery ... of chemical compounds that have a desired effect on ... To illustrate the power of the innovative technique, the ... shows promise for treating obesity-linked diabetes. At the same ...
Cached Biology News:Motor excitability predicts working memory 2Study offers clues to how plants evolved to cope with cold 2Study offers clues to how plants evolved to cope with cold 3Innovative screening strategy swiftly uncovers new drug candidates, new biology 2Innovative screening strategy swiftly uncovers new drug candidates, new biology 3Innovative screening strategy swiftly uncovers new drug candidates, new biology 4
(Date:8/28/2014)... , Aug. 28, 2014  Armetheon, Inc. ... developing novel mid- to late-stage cardiovascular drug candidates, ... in its first round of financing. The Series ... and Hercules Bioventures with participation from investors that ... pharmaceutical executive, Dr. Larry Hsu , the ...
(Date:8/28/2014)... Earlier this month, a report ... with the U.S. Air Force on the performance of ... that this type of fuel made from mustard seeds, ... important to America’s Eco friendly future. In fact, every ... to become independent of foreign oil over the next ...
(Date:8/27/2014)... Varian Medical Systems today broke ground ... Lake City manufacturing facility and allow for the consolidation ... create 1,000 new full time jobs in the state ... home to hardworking people with immense engineering and technical ... success in the manufacturing of our state-of-the-art X-ray technology,” ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 /PRNewswire/ ... research report is available in its catalogue: ... 2014-2018 http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials are materials that are readily decomposed ... differs from conventional non-degradable packaging in terms ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... Foundation (NSF) has awarded Northwestern University a six-year, $16.2 ... and Engineering Center (MRSEC), one of the oldest interdisciplinary ... which integrates educational activities with a scientific research program, ... Centers in the nation to successfully renew support from ...
... 8, 2011 HUYA Bioscience International, ... announced a strategic partnership with the Zhejiang Chinese ... will accelerate the global drug development of China,s ... partnership is expected to bring productive synergy between ...
... YORK, Sept. 8, 2011 Reportlinker.com announces that ... in its catalogue: Global ... http://www.reportlinker.com/p0611062/Global-High-Throughput-Screening-HTS-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Disc This ... Throughput Screening (HTS) in US$ Million. The ...
Cached Biology Technology:Collaborative science and engineering 2HUYA Bioscience International Forms Alliance With Zhejiang Chinese Medical University Life Science College 2HUYA Bioscience International Forms Alliance With Zhejiang Chinese Medical University Life Science College 3Global High Throughput Screening (HTS) Industry 2Global High Throughput Screening (HTS) Industry 3Global High Throughput Screening (HTS) Industry 4Global High Throughput Screening (HTS) Industry 5Global High Throughput Screening (HTS) Industry 6Global High Throughput Screening (HTS) Industry 7Global High Throughput Screening (HTS) Industry 8
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
Request Info...
Request Info...
... Nebulizers are available in two product models - ... two models is that the 6000AT+ includes a ... drier aerosol for improved detection limits and reduced ... a range of elements by 10-40 times. Note ...
Biology Products: