Navigation Links
Zebrafish study explains why the circadian rhythm affects your health
Date:8/28/2012

Disruptions to the circadian rhythm can affect the growth of blood vessels in the body, thus causing illnesses such as diabetes, obesity, and cancer, according to a new study from Linkping University and Karolinska Institutet in Sweden.

The circadian rhythm is regulated by a "clock" that reacts to both incoming light and genetic factors.

In an article now being published in the scientific journal Cell Reports, it is demonstrated for the first time that disruption of the circadian rhythm immediately inhibit blood vessel growth in zebra fish embryos.

Professor Yihai Cao leads a research group, which has demonstrated that the breaking point is the production of a very important signalling substance: vascular endothelial growth factor (VEGF). The formation of this substance requires a normal circadian rhythm.

During experiments with hours-old zebra fish embryos, the researchers manipulated their circadian rhythm through exposing them to lighting conditions varying from constant darkness to constant light. The growth of blood vessels in the various groups was then studied. The results showed that exposure to constant light (1800 lux) markedly impaired blood vessel growth; additionally, it affected the expression of genes that regulate the circadian clock.

"The results can definitely be translated into clinical circumstances. Individuals with disrupted circadian rhythms for example, shift workers who work under artificial lights at night, people with sleeping disorders or a genetic predisposition should be on guard against illnesses associated with disrupted blood vessel growth," says Lasse Dahl Jensen, researcher in Cardiovascular Physiology at Linkping University (LiU), and lead writer of the article.

Such diseases include heart attack, stroke, chronic inflammation, and cancer. Disruptions in blood vessel growth can also affect foetal development, women's reproductive cycles, and the healing of wounds.


'/>"/>

Contact: Lasse Dahl Jensen
lasse.jensen@liu.se
46-070-998-2096
Linkping University
Source:Eurekalert  

Page: 1

Related biology news :

1. Better housing conditions for zebrafish could improve research results
2. Zebrafish could hold the key to understanding psychiatric disorders
3. Environmental estrogens affect early developmental activity in zebrafish
4. Versatility of zebrafish research highlighted at international conference
5. Zebrafish research shows how dietary fat regulates cholesterol absorption
6. Zebrafish provide insights into causes and treatment of human diseases
7. Zebrafish -- the stars of biomedicine
8. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
9. Law that regulates shark fishery is too liberal: UBC study
10. New study will help protect vulnerable birds from impacts of climate change
11. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Zebrafish study explains why the circadian rhythm affects your health
(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed for ... complexity. Named in honor of pioneering researcher Rosalind Franklin, who made a ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... maternal age to IVF success. , After comparing the results from the fresh ...
Breaking Biology Technology: