Navigation Links
Zebrafish research shows how dietary fat regulates cholesterol absorption
Date:6/22/2012

at cholesterol was only absorbed when the fish ate a high-fat diet, not a low-fat diet. The fats and cholesterol were packaged into separate and clearly visible compartments within the cells. "You can tell which larvae had eggs for breakfast," he said.

The researchers also found that some long-chain fatty acids, particularly a common one called oleic acid, were especially effective for promoting cholesterol uptake. They provided evidence that oleic acid acts to drive a cholesterol transport protein from within the intestinal cell to the cell surface, where it can interact with cholesterol passing through the gut and pull it into the cell. More details of the new work will be published next week.

Their findings suggest a tightly regulated system in which cholesterol is only taken up by the intestine in the presence of fats. One reason such regulation is important, Dr. Walters said, is that unprocessed cholesterol can be toxic to cells and requires fatty acid-mediated modification to render it safe in a process called esterification.

"In nature, cholesterol and fatty acids go hand in hand. It makes sense that you could use dietary fatty acids as a cue for the transport protein to translocate to the cell surface and that dietary cholesterol may be available for absorption," he said. "The protein isn't displayed on the cell surface unless its preferred substrate for making cholesterol less toxic is also there."

Dr. Walters and his colleagues are now exploring the system's potential for studying and testing compounds that can block the absorption of dietary cholesterol, including one drug already on the market.

"Diet is a huge modulator of human disease," says Dr. Walters. "Our work demonstrates the power of the zebrafish larval system to provide fresh insights into the process of intestinal cholesterol absorption. It gives us a way to look at these processes for the first time in the context of a whole organism."


'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-351-0896
Genetics Society of America
Source:Eurekalert

Page: 1 2

Related biology news :

1. Versatility of zebrafish research highlighted at international conference
2. Environmental estrogens affect early developmental activity in zebrafish
3. Zebrafish could hold the key to understanding psychiatric disorders
4. Better housing conditions for zebrafish could improve research results
5. Notre Dame establishes professorships in adult stem cell research
6. Research: Many programs to help diabetics manage their health do work
7. Autism Speaks awards nearly $2.9 million to fund autism research
8. Researchers advance biometric security
9. University of Tennessee professor receives funding for clean coal research
10. Research could help track stem cells in the body
11. Argonne researchers receive 4 R&D 100 awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Europe,s most ... Patent Office to present a video retrospective of the most exciting ... Christofer Toumazou and Sophie Wilson   ... the Award   Starting on 22 January 2015 on   ...
(Date:12/24/2014)... launch in December 2014, the 1U™ app has ... to remember their usernames and passwords through replacing the antiquated ... assist people who have struggled to remember usernames and passwords, ... focuses on redefining identity, announced today that it is offering ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and Markets ... of the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... 2012, Apple introduced the fingerprint reading feature with the ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 31U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... The Wildlife Conservation Society tracked a southern elephant seal ... York to Sydney and back again. , WCS tracked the ... animal nicknamed Jackson was tagged on the beach ... WCS conservationists fitted Jackson with a small satellite transmitter that ...
... Therapeutics, Inc. announced today promising clinical results ... umbilical cord blood) as part of double-umbilical cord ... malignancies who have undergone reduced-intensity conditioning therapy.  The ... American Society of Hematology (ASH) meeting, being held ...
... of Toronto have found an explanation for how the ... system to prevent infection, offering a potential clue to ... multiple sclerosis. "The findings shed light on the ... gut," said Prof. Jennifer Gommerman, an Associate Professor in ...
Cached Biology News:Elephant seal travels 18,000 miles 2Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference 2Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference 3Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference 4Intestine crucial to function of immune cells, research shows 2Intestine crucial to function of immune cells, research shows 3
(Date:1/22/2015)... , a precision medicine software company that has developed a ... genomic, imaging and other biomedical data in research and clinical ... CEO of Aspera, an IBM Company, to its board as ... "We are pleased to welcome Michelle to ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... Solutions , Inc. (NASDAQ: BLFS ), a leading ... storage and cryopreservation freeze media and ... or the "Company"), today announced that it will hold its ... "Annual Meeting"). Because the expected date for the ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... FORT LAUDERDALE, Fla., Dec. 27 Imaging,Diagnostic Systems, ... laser,optical breast cancer imaging systems, announced that Tim ... Director effective January 1, 2008., (Logo: ... IDSI Chief Executive Officer and a Director of,the ...
... SOUTHAMPTON, Pa., Dec. 27 Environmental,Tectonics Corporation,s (Amex: ... today announced the purchase of two (2) BARA-MED(R) ... ETC is,excited to work with Comprehensive Healthcare Solutions ... operating Wound Healing Institutes,throughout the United States., ...
... 26 Insmed Inc. (Nasdaq:,INSM), a developer of ... requested a hearing before a Nasdaq Listing,Qualifications Panel ... the,Company,s common stock from the Nasdaq Global Market., ... Stock Market ("Nasdaq") on,December 20, 2007 indicating that ...
Cached Biology Technology:Imaging Diagnostic Systems CEO Announces Retirement 2Imaging Diagnostic Systems CEO Announces Retirement 3Environmental Tectonics Corporation Announces Sale of Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces Sale of Monoplace Hyperbaric Chambers 3Insmed to Appeal Delisting Notification From Nasdaq 2
No description available in Ensembl Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: