Navigation Links
Zebrafish provide insights into causes and treatment of human diseases
Date:7/6/2012

ghts into the fundamental processes disrupted in SMA.

Acute T-cell Lymphoblastic Leukemia and Lymphoma (T-ALL/T-LBL)

Human acute T-cell lymphoblastic leukemias (ALL) and lymphomas (LBL) have high relapse rates in pediatric patients and high mortality rates in adults. Hui Feng, M.D., Ph.D., currently at the Pharmacology Department and Center for Cancer Research at Boston University School of Medicine, is using a zebrafish model of leukemia to search for promising targets for new molecular treatments for these diseases.

To date, studies have identified several biological pathways involved in ALL and LBL, all with a known oncogene in common called c-Myc. However, Myc is so common, involved in regulating more than 15 percent of all genes, that it is very hard to study.

"Because this is a huge list of downstream targets, it is very challenging to predict which genes in the pathway to target to treat Myc-related cancers," said Dr. Feng.

In work performed in collaboration with Thomas Look, M.D., at the Dana-Farber Cancer Institute, Dr. Feng is combining the power of zebrafish genetics with human clinical studies to hone in on potential genes of interest.

Using a fish strain that reliably develops T-cell lymphoma by two months of age, they identified a novel gene called DLST that is involved in metabolism and energy production in cells. Evidence from human cancer cell lines and patients indicate that abnormally high levels of the protein may be involved in the human disease as well.

Reducing DLST activity in the fish significantly delayed tumor progression and growth, suggesting it is a promising target for developing new therapies for ALL and LBL.


'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Zebrafish research shows how dietary fat regulates cholesterol absorption
2. Versatility of zebrafish research highlighted at international conference
3. Environmental estrogens affect early developmental activity in zebrafish
4. Zebrafish could hold the key to understanding psychiatric disorders
5. Better housing conditions for zebrafish could improve research results
6. Yak genome provides new insights into high altitude adaptation
7. Innate immune system protein provides a new target in war against bacterial infections
8. Study provides first evidence of coevolution between invasive, native species
9. New discovery provides insight on long-standing pregnancy mystery
10. NineSigma Launches NineSights, the Worlds First Open Innovation Social Media Destination for Innovation Seekers and Solution Providers
11. Study provides new insights into structure of heart muscle fibers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)...  Synaptics Inc. (NASDAQ: SYNA ), a leading developer ... report financial results for the fourth quarter and fiscal ... close of market. The company will host a corresponding ... PT (5:00 p.m. ET), during which management may discuss ... live call, analysts and investors should dial 888-455-2260 (conference ...
(Date:7/8/2015)... July 8, 2015 Summary Pancreatic cancer ... fourth most fatal, with a mortality rate of 10.9 ... of pancreatic cancer patients has highlighted a significant need ... not being met by the current market. A ... products with varying molecule types and mechanisms of action, ...
(Date:7/7/2015)... Research and Markets ... the "Capacitive Fingerprint Sensors Patent Landscape" ... date, fingerprint sensing technology is the most reliable ... well developed. This patent landscape focuses on fingerprint ... domain of capacitive fingerprint sensors is closely linked ...
Breaking Biology News(10 mins):Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... emotions are experienced in the body. Emotions adjust ... the challenges detected in the environment. These sensations arising ... our emotional experiences. For example, anxiety may be experienced ... may trigger warm, pleasurable sensations all over the body. ...
... in vascular transplantation, but it remains unclear whether the stress ... study reported in the Neural Regeneration Research (Vol. ... 7 200 seconds was similar between the middle cerebral artery ... 18.7 kPa or 22.5 kPa. However, the strain increase at ...
... least 4C by 2100 and potentially more than 8C by ... new research published in Nature . Scientists found global ... estimates. , The research also appears to solve one of ... formation and whether this will have a positive or negative ...
Cached Biology News:Finnish research team reveals how emotions are mapped in the body 2Cloud mystery solved: Global temperatures to rise at least 4°C by 2100 2
(Date:7/29/2015)... 29, 2015 Research ... addition of the "Global Biosimilars Market, 2015 ... The Global Biosimilars Market, 2015 - 2025, ... growing biosimilars market. With the blockbuster biologics losing ... costs, biosimilars are being viewed as viable substitutes ...
(Date:7/29/2015)... CHICAGO , July 29, 2015  AmnioChor Inc., ... cell technology, is very pleased to announce that the ... has agreed to invest in their seed round ... OmniBank placental tissue storage capabilities. AmnioChor,s ... placenta, and the human stem cells living within those ...
(Date:7/29/2015)... -- Pfenex Inc. (NYSE MKT: PFNX) announced today that its ... Thursday, August 13, 2015, before the open of market.  ... a conference call to discuss the financial results and ... financial results and business update will be publicly distributed ... (US) or 1-412-542-4131 (international) and reference Pfenex to access ...
(Date:7/29/2015)... NJ (PRWEB) , ... July 29, 2015 , ... The ... approval of combination products , in particular, drug/device combinations. The current system received ... by the Initiative for Patient Centered Innovation (iPCI) of Fairleigh Dickinson University’s ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3
... of the Medical College of Wisconsin, UW-Medical School, the ... Milwaukee business television show, Avante's Leaders in the New ... , ,Dr. Jeffrey Smith, clinical assistant professor of medicine ... was joined by Mike Klein, founder and editorial director ...
... week from his position as director of the nonpartisan ... on the reasons for his ouster. , ,And while ... results of an audit of the bureaus performance as ... Speaker John Gard (R-Peshtigo) said the move was simple ...
... publicly traded biotech stocks continue to show strong growth, the ... the rest of the market is catching up). , ... growth of 42 percent versus the Nasdaq Composites growth of ... 12 percent. The Amex Biotech index matches the high growth ...
Cached Biology Technology:The Information Age of Healthcare - Leaders featured on local new economy show 2The Information Age of Healthcare - Leaders featured on local new economy show 3Wahl Mute on Firing from Legislative IT Bureau -- but politics could be to blame 2Midwest Public-Sector Biotech Continues to Sizzle 2
... PULSin is an innovative reagent for ... the cytoplasm of living cells. Unlike DNA ... Reagent the amount and timing of exogenous ... lethal proteins can now be studied. ...
... observations of cell cultures under precise, controlled ... strain parameters in addition to a microscope ... chamber used by the ST-195 is compatible ... can be used with Nikon, Olympus, Leica, ...
... research and biologic production demands on cell ... confirming viable cell populations. Therefore, both cell ... be determined accurately and precisely. The new ... and cost effective means to perform the ...
... PowerPac Basic power supply are used for electrophoretic ... cell accommodates two 7.5 x 10 cm gels ... assembly, Bio-Ice cooling unit, buffer tank, lid with ... basic power supply, 100-120 and 220-240 V, provides ...
Biology Products: