Navigation Links
Zebrafish provide a model for cancerous melanoma in humans
Date:5/25/2009

In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options.

Inside the cell, signals are delivered that direct the cell on whether to divide, migrate or even die. Cancer often results when the molecules that relay these signals become mutated so that they do not function normally. In cancer, cells divide, grow and migrate when they should not, therefore resulting in an aggressive disease that can spread throughout the body. A key molecule in this signaling pathway is RAS, and mutations in it are known to lead to cancer. In some cases, the type of RAS mutation is a predictor of a patient's response to treatment and their overall prognosis.

Therefore, scientists at the University of Manchester in England and the University Hospital Zrich in Switzerland generated several zebrafish with changes in RAS or other RAS-regulated proteins to create a useful model that can be used to study and understand human melanoma. Zebrafish are a useful tool to understand human disease because they are small, transparent, and easy to propagate and maintain. Tumors created from the pigmented cells of zebrafish, known as melanocytes, are easy to see against their thin, light colored bodies.

The research team notes that these fish may be a useful experimental tool for human disease. Many of the changes they made caused melanoma in the zebrafish, indicating that zebrafish respond similarly to changes in these signals as do humans. Zebrafish that were born from the original mutant fish displayed abnormal growth of their melanocytes, reminiscent of familial atypical mole and melanoma syndrome (FAMM) seen in humans. By producing other signaling molecules in the mutant fish, the researchers were able to identify a pathway that reduced the effects of RAS
'/>"/>

Contact: Sarah Sharpe
sarah.sharpe@biologists.com
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
2. AZTI-Tecnalia coordinates a platform promoting the use of zebrafish in scientific research
3. NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
4. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
5. Deadly genetic disease prevented before birth in zebrafish
6. A screening strategy using zebrafish targets genes that protect against hearing loss
7. Study shows how the zebrafish gets his stripe
8. Zebrafish to shed light on human mitochondrial diseases
9. A new mouse model provides insight into genetic neurological disorders
10. University of Florida study provides insight into evolution of first flowers
11. River delta areas can provide clue to environmental changes, Texas A&M prof says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... -- According to a new market research ... Vertical (BFSI, Airport, IT & Telecom, Utilities, Education, Defense ... 2020", published by MarketsandMarkets, defines and segments the Physical ... The global PIAM Market is estimated to grow from ... at a CAGR of 14.9 % from 2014 to ...
(Date:8/5/2015)... 2015 The biosensors market is proving highly ... into newer sectors, and development of devices resulting in ... has seen the entry of multiple participants each year ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... the Global Biosensors Market ( http://www.frost.com/nee9 ), finds ...
(Date:8/4/2015)... AMRI ) today reported financial and operating results for the second ... Second quarter contract revenue of $ 85.2 million, ... margins of 26 % , Second quarter ... from royalties in the current quarter , Operating ... pleased to present another strong financial quarter, with all our divisions ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... professionals send genes and healthy cells on their way ... repair tissue damage to arteries. But do they reach ... have developed a highly sensitive measuring method with which ... magnetic particles which are situated on the planted gene ...
... a protein is determined both by its structure and ... proteins had to be isolated for analyzing them. An ... University, and the Frankfurt Institute for Advanced Studies (FIAS) ... a protein in its natural environment, the living cell. ...
... 4 Innerscope Research(R), a revolutionary biometric media ... today the appointment of Andre Marquis as Senior ... will be responsible for expanding Innerscope,s offering into ... years experience driving innovative digital initiatives for start-ups ...
Cached Biology News:Protein structure determined in living cells 2Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing 2
(Date:9/2/2015)... 2015 Research and Markets ( ... Jain PharmaBiotech,s new report "Nanobiotechnology Applications, ... An increasing use of ... is anticipated. Nanotechnology will be applied at ... formulations for optimal delivery to diagnostic applications ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 ... ) has announced the addition of Jain PharmaBiotech,s ... Markets and Companies" to their offering. ... markets based on technologies and applications. The report ... basis for estimation of markets. Technologies include array ...
(Date:9/2/2015)... , Sep. 02, 2015 ... the addition of Jain PharmaBiotech,s new report "Gene ... offering. The markets for gene therapy are ... gene therapy product and it is marketed in ... are estimated for the years 2014-2024. The estimates are ...
(Date:9/2/2015)... ... September 02, 2015 , ... Drug companies increasingly are ... BCC Research reveals in its new report that the U.S. will generate the ... and generates the most market demand. , BCC Research examines plant-derived drugs ...
Breaking Biology Technology:Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3
... Madison,Wis. - Esker Software , ... headquarters in Madison, received a U.S. patent for ... mechanism for enabling content-based document delivery. , ,DeliveryWare ... to determine formatting, conversion and routing actions as ...
... Wis. Information technology professionals in Wisconsin announced ... Association of Wisconsin, a forum for information exchange ... than $14B in revenue and hires more than 55,000 ... 30 founding members, of which approximately a third are ...
... that the role of IT professional is one of diplomat between ... head of urgent communiqus and hushed conversations, exotic locales (like the ... of tense situations that could boil over into real conflict at ... deal of flexibility is the order of the day. , ...
Cached Biology Technology:Statewide IT association will address IT issues and priorities 2Statewide IT association will address IT issues and priorities 3IT is the New Foreign Service 2IT is the New Foreign Service 3
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... of Class II Biological Safety Cabinets ... to the world's highest safety standards. ... cabinets cannot be adjusted out of ... noise and arm rest ensure safety ...
... designed for paramagnetic bead precipitation from standard ... plates with no additional accessories. The stand ... standard SBS 96-well microplate footprint. The use ... easy and fast (as little as 30 ...
... with circular clear acrylic chamber for complete ... Oven features microprocessor operation for precise mixing ... unit., Carousel rotates at 11 rpm; ... removable , Bottle Capacity - four ...
Biology Products: