Navigation Links
Zebrafish provide a model for cancerous melanoma in humans
Date:5/25/2009

In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options.

Inside the cell, signals are delivered that direct the cell on whether to divide, migrate or even die. Cancer often results when the molecules that relay these signals become mutated so that they do not function normally. In cancer, cells divide, grow and migrate when they should not, therefore resulting in an aggressive disease that can spread throughout the body. A key molecule in this signaling pathway is RAS, and mutations in it are known to lead to cancer. In some cases, the type of RAS mutation is a predictor of a patient's response to treatment and their overall prognosis.

Therefore, scientists at the University of Manchester in England and the University Hospital Zrich in Switzerland generated several zebrafish with changes in RAS or other RAS-regulated proteins to create a useful model that can be used to study and understand human melanoma. Zebrafish are a useful tool to understand human disease because they are small, transparent, and easy to propagate and maintain. Tumors created from the pigmented cells of zebrafish, known as melanocytes, are easy to see against their thin, light colored bodies.

The research team notes that these fish may be a useful experimental tool for human disease. Many of the changes they made caused melanoma in the zebrafish, indicating that zebrafish respond similarly to changes in these signals as do humans. Zebrafish that were born from the original mutant fish displayed abnormal growth of their melanocytes, reminiscent of familial atypical mole and melanoma syndrome (FAMM) seen in humans. By producing other signaling molecules in the mutant fish, the researchers were able to identify a pathway that reduced the effects of RAS
'/>"/>

Contact: Sarah Sharpe
sarah.sharpe@biologists.com
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
2. AZTI-Tecnalia coordinates a platform promoting the use of zebrafish in scientific research
3. NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
4. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
5. Deadly genetic disease prevented before birth in zebrafish
6. A screening strategy using zebrafish targets genes that protect against hearing loss
7. Study shows how the zebrafish gets his stripe
8. Zebrafish to shed light on human mitochondrial diseases
9. A new mouse model provides insight into genetic neurological disorders
10. University of Florida study provides insight into evolution of first flowers
11. River delta areas can provide clue to environmental changes, Texas A&M prof says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... , May 20, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the addition ... the Global Iris Recognition Market"  report ... , ,This research service analyses trends ... the government and commercial sectors, globally. ...
(Date:5/19/2015)... NEW YORK , May 19, 2015  Technology ... resources both internally and in the cloud. Passwords and ... the use of OTP and standards-based specifications such as ... that the outmoded use of passwords presents for BYOD, ... needs a unified biometric identity protocol. ...
(Date:5/14/2015)... , May 14, 2015 Research and Markets ... of the "Fingerprint Sensors Market in Smart Mobile ... This report believes that 2014 was a watershed year ... Apple,s introduction of ,Apple Pay,. Apple gave fingerprint sensors ... mobile payment service. Fingerprint sensors are a must-have feature ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2
... events in the Asia-Pacific region opened at the Hong ... international delegates from over 60 countries. The IOF Regionals ... 15, is organized by the International Osteoporosis Foundation (IOF) ... the Osteoporosis Society of Hong Kong. The Meeting ...
... 2013 The critical enzyme beta-secretase1 (BACE1) is known to ... have now found increased levels of BACE1 in brains with ... for conversion of mild cognitive impairment to AD and may ... in the January issue of The American Journal of ...
... cities vary greatly in their dependence on the global ... of its most common food in its regional hinterland, ... The Copenhagen hinterland produces less than half of the ... time, researchers have mapped the food systems of capital ...
Cached Biology News:Osteoporosis prevention strategies and new bone research focus of major Hong Kong meeting 2Enzyme BACE1 may be important in predicting onset of Alzheimer disease 2Scientists map food security and self-provision of major cities 2Scientists map food security and self-provision of major cities 3
(Date:5/22/2015)... , May 22, 2015 Baylor Research Institute ... Translational Genomics Research Institute (TGen) in ... focus on accelerating early detection and treatments for patients with ... both institutions will lead to new clinical trials and access ... bridging the gap from bench to bedside across Baylor ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Specialty ... audit and been admitted to BPA Worldwide as ... Worldwide will track audience data for Specialty Pharmacy ... , “By becoming a member of BPA ... to providing our clients with the most reliable, ...
(Date:5/21/2015)... uBiome, the leading startup focused ... PicnicHealth, a healthcare company that collects and consolidates ... Bowel Disease (IBD) will receive a complementary PicnicHealth ... kit. Both companies were funded by Y Combinator ... more information on this partnership and how to ...
(Date:5/21/2015)... 21, 2015 W. R. Grace ... facility in Worms, Germany has received good manufacturing ... of the International Pharmaceutical Excipient Council (IPEC) Foundation. ... produce its SYLOID® FP brand of pharmaceutical grade ... following the Curtis Bay, Maryland (USA) and Sorocaba, ...
Breaking Biology Technology:Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Specialty Pharmacy Times Joins BPA Worldwide 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... the rising trend toward miniaturization, carbon nanotubes which ... and possess several unique and very useful properties ... blocks in nanosized electronic and mechanical devices. But it ... tendency to clump together, that make it difficult for ...
... testament to tight integration and ... excellent ... ), a,leader in radiology and medical image and information management solutions,today ... than 100 facilities that use MEDITECH(TM) as their health,information system. AMICAS ...
... device industry to benefit ... trial recruitment efforts, MINNEAPOLIS, May 27 ... has strengthened the,pharmaceutical side of its business with ... a commitment to leveraging differentiators unique,to the medical ...
Cached Biology Technology:Weizmann Institute scientists create new nanotube structures 2AMICAS Announces Integrations at More Than 100 MEDITECH Facilities 2AMICAS Announces Integrations at More Than 100 MEDITECH Facilities 3ThreeWire Expands Presence in the Pharmaceutical Arena 2
Collected from calves that are 10 days old or less. Sterile, cell culture tested, US Origin...
... Target Retrieval Solution, pH 9 (x 10) ... pH 9, intended for heat-induced target retrieval ... well-suited for use on formalin-fixed, paraffin-embedded tissue ... 0.01 mol/L citrate buffer, pH 6, the ...
MAb to Yersinia pestis F1 Ag. Yersinia pestis F1 Antigen EB Strain...
... any scanner into a gel densitometer. Although ... the basic operation simply consists of converting ... into pixel density / intensity values through ... Turn your scanner into a high speed ...
Biology Products: