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Zebrafish models identify high-risk genetic features in leukemia patients
Date:5/10/2011

an be cured with milder chemotherapy that produces fewer side effects, both during treatment and long after treatment is complete."

Kimble Frazer, M.D., Ph.D., assistant professor of pediatrics at the U of U and a member of the Trede Lab, is co-senior author of the article. "One of the genes identified in the study had not previously been recognized as important in T-ALL," said Frazer. "Another gene, associated with patients whose outcomes were least favorable, has not received enough research attention to even have an official name. It only has an 'address' that tells its location on a specific chromosome."

The researchers stress that their results are still preliminary. They plan further laboratory studies to bolster the case that this unnamed gene with the address C7orf60 is important in the development of T-ALL. Additional zebrafish experiments that focus on this gene could be designed to amplify its effects and confirm its contribution to creating more, or hardier, leukemia. In the end, the research could lead to a test that would allow doctors to determine the best course of treatment for an individual leukemia patient by analyzing a blood sample.

Both Trede and Frazer credit the article's first-listed author, Lynnie Rudner, with much of the work leading to the published results. Rudner is the recipient of the American Medical Association (AMA) Foundation's Seed Grant, one of only 38 individuals nationwide who received a seed grant in 2010, and a student in the U of U's M.D./Ph.D. program, which produces graduates qualified in both clinical practice and laboratory research.


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Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

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