Navigation Links
Zebrafish models identify high-risk genetic features in leukemia patients
Date:5/10/2011

SALT LAKE CITYLeukemia is the most common childhood cancer; it also occurs in adults. Now researchers working with zebrafish at Huntsman Cancer Institute (HCI) at the University of Utah have identified previously undiscovered high-risk genetic features in T-cell acute lymphocytic leukemia (T-ALL), according to an article published online May 9, 2011, in the cancer research journal Oncogene. When compared to samples from human patients with T-ALL, these genetic characteristics allowed scientists to predict which patients may have more aggressive forms of the disease that either recur after remission or do not respond to treatment.

While there are several subtypes, in all leukemias the body overproduces certain blood cells that have not matured properly. In this study, the researchers investigated a particular type of leukemia that results from genetic mutations in T-cells, a type of white blood cell found in both humans and zebrafish.

Using a technique called serial transplantation, the research team studied T-ALL in zebrafish and selected cancer cells from those in which the disease advanced more rapidly for further testing. This method allowed the research team to zero in on genes associated with T-ALL's most aggressive forms. They then compared these genetic features to samples from human patients whose clinical outcomes with T-ALL are known.

"We can cure 80% of the children who come to us with leukemia, but there are 20 percent we cannot cure. Sometime the cures come at a high cost to patients in immediate and delayed side effects from chemotherapy," said Nikolaus Trede, M.D., Ph.D., associate professor in the Department of Pediatrics at the University of Utah (U of U) School of Medicine, HCI investigator, and a senior author of the article. "These results may lead to tests that can show which children with the disease need the strongest chemotherapy to overcome their cancer. Children with less aggressive forms of leukemia c
'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
2. NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
3. AZTI-Tecnalia coordinates a platform promoting the use of zebrafish in scientific research
4. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
5. Zebrafish provide a model for cancerous melanoma in humans
6. Pitt team finds molecule that regulates heart size by using zebrafish screening model
7. Drug-proof zebrafish reveal secrets of addiction
8. Zebrafish swim into drug development
9. The zebrafishs neural circuit prevents it from biting off more than it can chew
10. Zebrafish yield clues to how we process visual information
11. New research tool targets microRNA expression in zebrafish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... international team of researchers led by MIT has explained ... to slip past traditional safety screens and kill dozens ... The team, led by Professor Ram Sasisekharan of ... as oversulfated chondroitin sulfate (OSCS). The researchers present their ...
... of researchers at New York Medical College has discovered ... specialized to generate heat. A paper published April 21, ... the surprising implication that the same lack of heat-generating ... , The paper, The brown adipocyte differentiation pathway in ...
... people with good oral health could become the first ... response to periodontal disease treatments, say researchers at the ... protein called HtpG, the bug that makes it is ... antibody also has potential as a vaccine candidate, according ...
Cached Biology News:MIT-led teams unravel heparin death mystery 2MIT-led teams unravel heparin death mystery 3Medical College researchers find dinosaur clues in fat 2Presence of certain antibodies signals healthier teeth and gums 2
(Date:4/16/2015)...  Scientists from Cleave Biosciences will be participating in ... the American Association for Cancer Research Annual Meeting 2015 ... April 19, 2015 from 3:15pm to 5:15pm ET. ... present new in vivo and mechanism of action study ... a critical enzyme that controls various aspects of protein ...
(Date:4/16/2015)... , April 16, 2015  EMD Serono today ... Darmstadt, Germany , appointed ... Head of Global Clinical Development.  Dr. Reicin brings ... experience in Oncology and Immunology. She is an ... served as a Vice President in various capacities ...
(Date:4/16/2015)... and MENLO PARK, Calif. ... (OTCQX: DMPI) (DelMar and the Company), a biopharmaceutical ... in new orphan drug indications, today announced that the ... as a clinical trial site for the ongoing, multicenter ... glioblastoma multiforme (GBM), the most common and deadly form ...
(Date:4/16/2015)... BETHESDA, Md. , April 16, 2015 /PRNewswire/ ... Bio"), a biotechnology company developing non-toxic DCVax® personalized ... has been included in the Loncar Cancer Immunotherapy ... help investors better track the immunotherapy field within ... founders have selected "the top 25 companies" in ...
Breaking Biology Technology:Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 2DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 3DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 4DelMar Pharmaceuticals Adds Fourth Clinical Trial Site in Phase I/II Multicenter Study of VAL-083 for Recurrent Malignant Glioma 5NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 2NW Bio Included In New Index Of The "Top 25 Cancer Immunotherapy Companies" 3
... principle, stem cells offer scientists the opportunity to create specific ... by age or disease. In reality, coaxing stem cells to ... the least. In a paper published this week in ... , however, scientists at the University of Georgia describe a ...
... 14, 2011 MedImmune today announced the ... the work of the next generation of scientific leaders ... autoimmune (RIA) disease. Graduate students and postdoctoral fellows were ... of a competition sponsored by MedImmune, the global biologics ...
... inVentiv Health, Inc., offering best-in-class clinical, commercial and ... that it has been selected by the specialty ... support, as well as recruiting and sales force ... Type 2 diabetes. inVentiv Health ...
Cached Biology Technology:New method for producing precursor of neurons, bone and other important tissues from stem cells 2New method for producing precursor of neurons, bone and other important tissues from stem cells 3MedImmune Announces Winners of Its 6th Annual Global Abstract Competition 2inVentiv Health Selected to Provide Sales Operations Support for Santarus 2inVentiv Health Selected to Provide Sales Operations Support for Santarus 3inVentiv Health Selected to Provide Sales Operations Support for Santarus 4
...
Kit for testing the ability of a compound to simulate lipolysis in cultured human adipocytes. Kit contains controls, buffers and reagents for detecting glycerol and non-esterified free fatty acids. A...
... analysis kit for 10 chips provides the ... analysis with the Experion automated electrophoresis system. ... 3 x 520 microliters Pro260 gel, 45 ... (10-260 kD), 400 microliters Pro260 sample buffer, ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Biology Products: