Navigation Links
Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
Date:1/31/2013

Zebrafish, the staple of genetic research, may hold the answer to repairing damaged retinas and returning eye-sight to people.

University of Alberta researchers discovered that a zebrafish's stem cells can selectively regenerate damaged photoreceptor cells.

Lead U of A researcher Ted Allison says that for some time geneticists have known that unlike humans, stem cells in zebrafish can replace damaged cells involved in many components of eyesight. Rods and cones are the most important photoreceptors. In humans, rods provide us with night vision while cones give us a full colour look at the world during the day-time.

What was not known says Allison was whether stem cells could be instructed to only replace the cones in its retina. This could have important implications for human eyesight.

"This is the first time in an animal research model that stem cells have only repaired damaged cones," said Allison. "For people with damaged eyesight repairing the cones is most important because it would restore day-time colour vision.

The researchers say that to date almost all success in regenerating photoreceptor cells has been limited to rods not cones. Most of these previous experiments were conducted on nocturnal rodents, animals that require good night vision so they have far more rods than cones.

"This shows us that when cones die in a cone-rich retina, it is primarily cones that regenerate," said Allison. "This suggests the tissue environment provides cues to instruct stem cell how to react."

The researchers say this shows some hope for stem cell therapy that could regenerate damaged cones in people, especially in the cone-rich regions of the retina that provide daytime/colour vision.

Allison says the next step for his team is to identify the particular gene in zebrafish gene that activates repair of damaged cones.


'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. Surprising teaching tool in K-12 science education -- Zebrafish research
2. Zebrafish study explains why the circadian rhythm affects your health
3. Zebrafish -- the stars of biomedicine
4. Zebrafish provide insights into causes and treatment of human diseases
5. Zebrafish research shows how dietary fat regulates cholesterol absorption
6. Versatility of zebrafish research highlighted at international conference
7. Environmental estrogens affect early developmental activity in zebrafish
8. Zebrafish could hold the key to understanding psychiatric disorders
9. Better housing conditions for zebrafish could improve research results
10. Chicken and egg question (and answer) for rural Uganda
11. Seafood, wild or farmed? The answer may be both
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For the second ... a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, ... from US2020. , US2020’s mission is to change the trajectory of STEM education ...
(Date:10/10/2017)... firm Parks Associates announced today that Tom Kerber , ... Meeting , October 11 in Scottsdale, Arizona . Kerber ... smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... business process optimization firm for the life sciences and healthcare industries, announces a ... in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
Breaking Biology Technology: