Navigation Links
Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
Date:1/31/2013

Zebrafish, the staple of genetic research, may hold the answer to repairing damaged retinas and returning eye-sight to people.

University of Alberta researchers discovered that a zebrafish's stem cells can selectively regenerate damaged photoreceptor cells.

Lead U of A researcher Ted Allison says that for some time geneticists have known that unlike humans, stem cells in zebrafish can replace damaged cells involved in many components of eyesight. Rods and cones are the most important photoreceptors. In humans, rods provide us with night vision while cones give us a full colour look at the world during the day-time.

What was not known says Allison was whether stem cells could be instructed to only replace the cones in its retina. This could have important implications for human eyesight.

"This is the first time in an animal research model that stem cells have only repaired damaged cones," said Allison. "For people with damaged eyesight repairing the cones is most important because it would restore day-time colour vision.

The researchers say that to date almost all success in regenerating photoreceptor cells has been limited to rods not cones. Most of these previous experiments were conducted on nocturnal rodents, animals that require good night vision so they have far more rods than cones.

"This shows us that when cones die in a cone-rich retina, it is primarily cones that regenerate," said Allison. "This suggests the tissue environment provides cues to instruct stem cell how to react."

The researchers say this shows some hope for stem cell therapy that could regenerate damaged cones in people, especially in the cone-rich regions of the retina that provide daytime/colour vision.

Allison says the next step for his team is to identify the particular gene in zebrafish gene that activates repair of damaged cones.


'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. Surprising teaching tool in K-12 science education -- Zebrafish research
2. Zebrafish study explains why the circadian rhythm affects your health
3. Zebrafish -- the stars of biomedicine
4. Zebrafish provide insights into causes and treatment of human diseases
5. Zebrafish research shows how dietary fat regulates cholesterol absorption
6. Versatility of zebrafish research highlighted at international conference
7. Environmental estrogens affect early developmental activity in zebrafish
8. Zebrafish could hold the key to understanding psychiatric disorders
9. Better housing conditions for zebrafish could improve research results
10. Chicken and egg question (and answer) for rural Uganda
11. Seafood, wild or farmed? The answer may be both
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... TOKYO , June 24, 2016  Regular discussions on ... to take place between the two entities said Poloz. ... in Ottawa , he pointed to the ... and the federal government. ... Poloz said, "Both institutions have common economic goals, why not ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
Breaking Biology Technology: