Navigation Links
Zebrafish could hold the key to understanding psychiatric disorders
Date:5/17/2012

Scientists at Queen Mary, University of London have shown that zebrafish could be used to study the underlying causes of psychiatric disorders.

The study, published online in the journal Behavioural Brain Research, found zebrafish can modify their behaviour in response to varying situations.

Dr Caroline Brennan, from Queen Mary's School of Biological and Chemical Sciences who led the study, said: "Zebrafish are becoming one of the most useful animal models for studying the developmental genetic mechanisms underlying many psychiatric disorders; they breed prolifically and we have many new and exciting techniques that allow us to explore their genetic make-up in the laboratory."

The scientists took 15 zebrafish through a series of experiments involving colour choice to test aspects of behaviour associated with psychiatric disease.

The fish were given a choice between two colours - they learnt to choose one of the colours which gave them food. The colours were then reversed and they learnt to change their colour choice.

The scientists then introduced a new set of colours and started the process again. The fish were able to change their behaviour accordingly, learning the new set of colours much faster than the original set, a process psychologists call 'behavioural flexibility'.

The research challenges previous studies which suggested fish were unable to elicit behavioural flexibility, unlike mammals and humans, because they didn't have a frontal cortex.

"Problems with behavioural flexibility, and general deficits in attention, are key symptoms displayed by people suffering a variety of psychological disorders related to impulse control, such as drug addiction, attention-deficit hyperactivity disorder (ADHD) and some personality disorders," Dr Brennan said.

"The results of our study suggest that there may be a role for zebrafish in the future as a useful comparative model to study the cause and prognosis of some of these disorders."

Zebrafish are often used by neuroscientists to explore mechanisms controlling behaviour and in the search for new compounds to treat behavioural disease such as addiction, attention deficit disorders or autism. This study adds further weight to the argument for using zebrafish in the study of these disorders and conditions.


'/>"/>

Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London
Source:Eurekalert

Related biology news :

1. Better housing conditions for zebrafish could improve research results
2. Growth hormone helps repair the zebrafish ear
3. Zinc and the zebrafish
4. Zebrafish regrow fins using multiple cell types, not identical stem cells
5. Zebrafish models identify high-risk genetic features in leukemia patients
6. In a genetic research first, Mayo Clinic turns zebrafish genes off and on
7. New research tool targets microRNA expression in zebrafish
8. Zebrafish yield clues to how we process visual information
9. The zebrafishs neural circuit prevents it from biting off more than it can chew
10. Zebrafish swim into drug development
11. Drug-proof zebrafish reveal secrets of addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2017)... 3, 2017 A new independent identity strategy ... LLP (IdSP) . Designed to fill a critical niche ... market, founding partners Mark Crego and ... just in identity expertise that span federal governments, the ... The Crego-Kephart combined expertise has a common theme born ...
(Date:2/2/2017)... , Feb. 1, 2017  Central to ... and meaningful advances worldwide, The Japan Prize Foundation ... Prize, who have pushed the envelope in their ... and Communication. Three scientists are being recognized with ... achievements that not only contribute to the advancement ...
(Date:1/30/2017)... FRANCISCO , Jan. 30, 2017   Invitae ... the fastest growing genetic information companies, today announced that ... financial results and provide 2017 guidance on Monday, February ... conference call that day at 4:45 p.m. Eastern / ... Invitae,s management team will briefly review financial results, guidance, ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... (PRWEB) , ... February 16, 2017 , ... Avomeen & ... The event will be held at Avomeen Analytical Services (4840 Venture Dr., Ann ... MichBio member organization. They provide an opportunity to interact with peers, make new connections ...
(Date:2/16/2017)... Calif. , Feb. 16, 2017  ArmaGen, ... developing groundbreaking therapies to treat severe neurological disorders, ... children treated with AGT-181, the company,s investigational therapy ... (also known as mucopolysaccharidosis type I, or MPS ... 2 proof-of-concept (POC) study, presented today at the ...
(Date:2/16/2017)... 16, 2017 Patient Care ... innovative telemedicine application, new and leading edge therapies ... a boom worldwide. The healthcare sector as whole ... services and new therapies for companies such as ... Cellectar Biosciences, Inc. (NASDAQ: CLRB ), ...
(Date:2/16/2017)... Malden, MA (PRWEB) , ... February 16, 2017 ... ... viscoelastic 4-level cervical case. Dr. Kingsley Chin, professor and Harvard trained surgeon, completed ... The procedure was performed on a 55-year-old practicing female physician suffering from degenerative ...
Breaking Biology Technology: