Navigation Links
Zebrafish could hold the key to understanding psychiatric disorders
Date:5/17/2012

Scientists at Queen Mary, University of London have shown that zebrafish could be used to study the underlying causes of psychiatric disorders.

The study, published online in the journal Behavioural Brain Research, found zebrafish can modify their behaviour in response to varying situations.

Dr Caroline Brennan, from Queen Mary's School of Biological and Chemical Sciences who led the study, said: "Zebrafish are becoming one of the most useful animal models for studying the developmental genetic mechanisms underlying many psychiatric disorders; they breed prolifically and we have many new and exciting techniques that allow us to explore their genetic make-up in the laboratory."

The scientists took 15 zebrafish through a series of experiments involving colour choice to test aspects of behaviour associated with psychiatric disease.

The fish were given a choice between two colours - they learnt to choose one of the colours which gave them food. The colours were then reversed and they learnt to change their colour choice.

The scientists then introduced a new set of colours and started the process again. The fish were able to change their behaviour accordingly, learning the new set of colours much faster than the original set, a process psychologists call 'behavioural flexibility'.

The research challenges previous studies which suggested fish were unable to elicit behavioural flexibility, unlike mammals and humans, because they didn't have a frontal cortex.

"Problems with behavioural flexibility, and general deficits in attention, are key symptoms displayed by people suffering a variety of psychological disorders related to impulse control, such as drug addiction, attention-deficit hyperactivity disorder (ADHD) and some personality disorders," Dr Brennan said.

"The results of our study suggest that there may be a role for zebrafish in the future as a useful comparative model to study the cause and prognosis of some of these disorders."

Zebrafish are often used by neuroscientists to explore mechanisms controlling behaviour and in the search for new compounds to treat behavioural disease such as addiction, attention deficit disorders or autism. This study adds further weight to the argument for using zebrafish in the study of these disorders and conditions.


'/>"/>

Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London
Source:Eurekalert

Related biology news :

1. Better housing conditions for zebrafish could improve research results
2. Growth hormone helps repair the zebrafish ear
3. Zinc and the zebrafish
4. Zebrafish regrow fins using multiple cell types, not identical stem cells
5. Zebrafish models identify high-risk genetic features in leukemia patients
6. In a genetic research first, Mayo Clinic turns zebrafish genes off and on
7. New research tool targets microRNA expression in zebrafish
8. Zebrafish yield clues to how we process visual information
9. The zebrafishs neural circuit prevents it from biting off more than it can chew
10. Zebrafish swim into drug development
11. Drug-proof zebrafish reveal secrets of addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... , June 21, 2016 NuData Security announced ... new role of principal product architect and that ... director of customer development. Both will report directly ... officer. The moves reflect NuData,s strategic growth in ... to high customer demand and customer focus values. ...
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/7/2016)... TORONTO , June 7, 2016  Syngrafii ... begun a business relationship that includes integrating Syngrafii,s ... pilot branch project. This collaboration will result in ... for the credit union, while maintaining existing document ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... to enabling healthier lives through the development of innovative ... of the United States denied ... that the claims of Sequenom,s U.S. Patent No. 6,258,540 ... eligibility criteria established by the Supreme Court,s Mayo Collaborative ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... ... , ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical ... mesothelioma. Their findings are the subject of a new article on the Surviving Mesothelioma ... in the blood, lung fluid or tissue of mesothelioma patients that can help point ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
Breaking Biology Technology: