Navigation Links
Youthful stem cells from bone can heal the heart, Temple scientists report
Date:9/4/2013

capable and a little more set in their ways, like toddlers. While they may need some coaxing into action, they are more likely to stay in their resident tissue.

To figure out how CBSCs might behave in the heart in the first place, Houser's team, led by Temple graduate student Jason Duran, began by collecting the cells from mouse tibias. The particular mice used had been engineered with green fluorescent protein (GFP), which meant that the CBSCs carried a green marker to allow for their later identification. The cells were then expanded in petri dishes in the laboratory before being injected directly into the hearts of non-GFP mice that had suffered heart attacks. Some mice received cardiac stem cells instead of CBSCs.

In the following weeks, as the team monitored the progress of the mice, they found that the youthfulness of the CBSCs had prevailed. The cells had triggered the growth of new blood vessels in the injured tissue, and six weeks after injection, they had differentiated, or matured, into heart muscle cells. While generally smaller than native heart cells, the new cells had the same functional capabilities, and overall they had improved survival and heart function. Similar improvements were not observed in the subset of mice treated with cardiac stem cells. Nor was there evidence in those mice that the cardiac cells had undergone differentiation.

The findings challenge the general assumption that cardiac stem cells, because they reside in the heart, are the cells most capable of repairing damaged heart tissue. For that reason, according to Houser, the new paper likely will be controversial.

"What we did generates as many questions as it does answers," he said. "Cell therapy attempts to repopulate the heart with new heart cells. But which cells should be used, and when they should be put into the heart are among many unanswered questions."

To address at least some of those questions, Houser's team plans next to
'/>"/>

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
215-707-7882
Temple University Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research identifies how mouth cells resist Candida infection
2. Statins may slow human aging by protecting against telomere shortening: A feature of senescent cells
3. UC Davis team spikes stem cells to generate myelin
4. Why are some cells more cancer prone?
5. Harvard Stem Cell researchers create cells that line blood vessels
6. UCI-led study reveals how SARS virus hijacks host cells
7. Fetal tissue-derived stem cells may be ideal source for repairing tissues and organs
8. Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
9. Celery, artichokes contain flavonoids that kill human pancreatic cancer cells
10. Sympathetic neurons cross talk with pancreas cells during early development
11. Lampreys provide hints to ancient immune cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... the "Global Gesture Recognition Market in Automotive Sector ... analysts forecast the Global Gesture Recognition market in Automotive ... the period 2013-2018. Gesture recognition is the ... different gestures of an individual. Gesture recognition technology can ...
(Date:3/24/2015)... NexID Biometrics LLC, whose spoof-mitigation technology boosts protection ... beginning of shipments of version 2.0 of its industry ... in Potsdam, N.Y. , is making ... here today at the Walter E. Washington Convention Center. ... boosts the accuracy rate range to 96.5 to 99.5 ...
(Date:3/23/2015)... LOS ANGELES , March 23, 2015  In ... in Federal fraud case conviction losses. This figure accounts ... fraud, which, according to The Nilson Report, exceeds $11 ... an investigative tool after a crime has occurred. Investor ... Agent and polygraph expert Joe Paolella partnered ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... severely disrupt neurotransmission and inhibit delivery of key proteins ... Laboratory (MBL) researchers have found. The particles are ... known to accumulate and form plaques in the brain ... haven,t aggregated into plaquesthese are increasingly being seen as ...
... there are many scientific works dealing solely with the ... to an infection," says Klaus Schughart, head of the ... researchers have now discovered that an excessive immune response ... in mice. This overreaction has genetic roots. The findings ...
... waters, the researchers found evidence of estrogenic compounds leaching ... more, these chemicals are potent in vivo and result ... Zealand mud snail. These findings, which show for the ... packaging materials act as functional estrogens, are published in ...
Cached Biology News:Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimer's disease 2The host makes all the difference 2Hormone-mimics in plastic water bottles -- just the tip of the iceberg? 2
(Date:4/21/2015)... April 21, 2015 The North American chromatography systems ... from 2014 to 2019. Based on geography, this market has ... and Mexico . The U.S. accounted for ... . The major factors driving the growth of chromatography systems ... industries are the prime users of chromatography techniques. ...
(Date:4/21/2015)... 21, 2015 Research and Markets ... the "Complete 2015-16 Induced Pluripotent Stem Cell ... Stem cell research and experimentation have ... as stem cells have the unique ability to ... nature allows them to differentiate into a wide ...
(Date:4/21/2015)... Contract Research Organization XenoTech, LLC , ... a new 41,500 ft2 facility. The planned move will ... 16825 W. 116th St. in Lenexa, KS. The new ... laboratory space, will remain in the Kansas City metro area, ... than twenty years ago. Remaining in the Kansas City ...
(Date:4/21/2015)... 2015  Scientists from the J. Craig Venter ... a paper today outlining new synthetic biology methods ... The researchers, led by first author Bogumil ... Weyman , Ph.D., conclude that these new and ... genetics and thus facilitate advances in engineering these ...
Breaking Biology Technology:North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 3Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014 2XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014 3Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 2Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 3
... stimulates activity in the brain. Even the mere possibility of ... the brain called the striatum. A team of Japanese researchers ... Cortex , published by Elsevier, the results of a study ... monetary task and found high-risk/high-gain options to cause higher levels ...
... , HAIKOU CITY, China, ... Amex: CPHI ), which develops,manufactures, and markets specialty pharmaceutical ... Brean Murray, Carret & Co. 2009 China,Growth Conference, to be ... York. Management is scheduled to present at 4:20 pm ...
... , ... a new market research report is available in ... Global Market Intelligence Report , ... key discipline operating on the forefront of the ...
Cached Biology Technology:Monetary gain and high-risk tactics stimulate activity in the brain 2China Pharma Holdings, Inc. to Present at Brean Murray China Growth Conference 2Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 2Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 3Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 4Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 5Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 6Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 7
Agar, 5 lb. Bacteriological.Moisture: < 10%, ash: < 6.5%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
... Clone/PAD: ZMD.414. Immunogen: Synthetic peptide derived ... and rat mTOR (Mammalian target of rapamycin ... the human mTOR protein. On Western ... ~235 kDa. Reactivity: Human (positive control: ...
...
Biology Products: