Navigation Links
Youthful stem cells from bone can heal the heart, Temple scientists report
Date:9/4/2013

capable and a little more set in their ways, like toddlers. While they may need some coaxing into action, they are more likely to stay in their resident tissue.

To figure out how CBSCs might behave in the heart in the first place, Houser's team, led by Temple graduate student Jason Duran, began by collecting the cells from mouse tibias. The particular mice used had been engineered with green fluorescent protein (GFP), which meant that the CBSCs carried a green marker to allow for their later identification. The cells were then expanded in petri dishes in the laboratory before being injected directly into the hearts of non-GFP mice that had suffered heart attacks. Some mice received cardiac stem cells instead of CBSCs.

In the following weeks, as the team monitored the progress of the mice, they found that the youthfulness of the CBSCs had prevailed. The cells had triggered the growth of new blood vessels in the injured tissue, and six weeks after injection, they had differentiated, or matured, into heart muscle cells. While generally smaller than native heart cells, the new cells had the same functional capabilities, and overall they had improved survival and heart function. Similar improvements were not observed in the subset of mice treated with cardiac stem cells. Nor was there evidence in those mice that the cardiac cells had undergone differentiation.

The findings challenge the general assumption that cardiac stem cells, because they reside in the heart, are the cells most capable of repairing damaged heart tissue. For that reason, according to Houser, the new paper likely will be controversial.

"What we did generates as many questions as it does answers," he said. "Cell therapy attempts to repopulate the heart with new heart cells. But which cells should be used, and when they should be put into the heart are among many unanswered questions."

To address at least some of those questions, Houser's team plans next to
'/>"/>

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
215-707-7882
Temple University Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research identifies how mouth cells resist Candida infection
2. Statins may slow human aging by protecting against telomere shortening: A feature of senescent cells
3. UC Davis team spikes stem cells to generate myelin
4. Why are some cells more cancer prone?
5. Harvard Stem Cell researchers create cells that line blood vessels
6. UCI-led study reveals how SARS virus hijacks host cells
7. Fetal tissue-derived stem cells may be ideal source for repairing tissues and organs
8. Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
9. Celery, artichokes contain flavonoids that kill human pancreatic cancer cells
10. Sympathetic neurons cross talk with pancreas cells during early development
11. Lampreys provide hints to ancient immune cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/11/2014)... Dec. 10, 2014  Data Sciences International (DSI), ... released a new series of digital telemetry implants ... researchers. M series, part of the PhysioTel™ Digital ... best possible physiologic data when incorporating functional endpoints ... endpoints to toxicology studies has evolved from short ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... 2009 Olympus, a precision technology leader, creating ... consumer electronics products, today announced the introduction of ... a customized and comprehensive system for examining high ... and express viewing modes, the software reduces the ...
... clinics the world over could benefit from new software* created ... a team of scientists has found a way to improve ... the University of Alabama at Birmingham (UAB). Pneumonia is ... years of age and poses a serious risk to elderly ...
... leap for averting natural and man-made disasters on earth. ... orbit with sensors on the ground and in the air ... give advance warnings about water contamination after a forest fire, ... flag is raised on earth, or tell people in China ...
Cached Biology News:Improved Endo Capsule Software enhances diagnostic experience 2Scientists create NICE solution to pneumonia vaccine testing problems 2Sensing disasters from space 2
(Date:12/22/2014)... , Dec. 22, 2014 GenomeDx Biosciences today ... Prostate Cancer Classifier, a genomic test for prostate cancer, ... high-risk men managed by radical prostatectomy without adjuvant therapy. ... is relatively uncommon, using tumor genomics to identify these ... disease is an important advance. The study has been ...
(Date:12/22/2014)... Chicago, Illinois (PRWEB) December 22, 2014 ... representing tenants and occupiers of commercial real estate, has ... two new offices in Perth and Brisbane, Western Australia, ... board of directors. , ITRA Global / ACORPP ... and totally independent consultancy company providing property services to ...
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... , Dec. 19, 2014  Roche (SIX: RO, ROG; ... Technologies, Inc. (Bina), a privately held company based ... USA. Bina provides a big data platform for ... (NGS) data. Bina,s proprietary on-market Genomic Management Solution, ... researchers to perform fast and scalable analyses to ...
Breaking Biology Technology:Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3
... CHAPEL HILL, N.C., Nov. 5 As ... market, considerable efforts,are placed on strategy and ... largely focus on revenue growth and little ... launch excellence, a recent study,was conducted by ...
... Assay Designs, Inc., a leading,provider of ... life science,and translational research markets, has announced ... The agreement enables Assay Designs to,distribute approximately ... their U.S. and Canadian customers. This major ...
... N.Y., Nov. 5 Misonix, Inc.,(Nasdaq: MSON ... device,technology, which in Europe is used for the ... conditions, has entered into a new, three,year, exclusive ... Rotterdam, The Netherlands, for the distribution of the,SonaStar(TM) ...
Cached Biology Technology:New Study Provides Key Findings for Biopharma Product Launch Evaluation 2Assay Designs(TM), Inc. Announces Agreement with Abnova Corp. of Taiwan 2Misonix Announces New Distribution Agreement for The Netherlands 2Misonix Announces New Distribution Agreement for The Netherlands 3
Peptide-affinity Purified Polyclonal Antibody to Histamine H2 Receptor...
Monoclonal Antibody to GLP Immunogen: Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3)...
Homo sapiens MEP50 protein, mRNA...
Can be used for the quantitative recovery of small amounts of nucleic acids within dilute solutions. 5mg/ml...
Biology Products: