Navigation Links
Your gut has taste receptors
Date:8/20/2007

Researchers in the Department of Neuroscience at Mount Sinai School of Medicine have identified taste receptors in the human intestines. The taste receptor T1R3 and the taste G protein gustducin are critical to sweet taste in the tongue. Research now shows these two sweet-sensing proteins are also expressed in specialized taste cells of the gut where they sense glucose within the intestine.

We now know that the receptors that sense sugar and artificial sweeteners are not limited to the tongue. Our work is an important advance for the new field of gastrointestinal chemosensation - how the cells of the gut detect and respond to sugars and other nutrients, said lead author, Robert F. Margolskee, MD, PhD Professor of Neuroscience at Mount Sinai School of Medicine. Cells of the gut taste glucose through the same mechanisms used by taste cells of the tongue. The gut taste cells regulate secretion of insulin and hormones that regulate appetite. Our work sheds new light on how we regulate sugar uptake from our diets and regulate blood sugar levels.

These new findings, just published online in the August 20th, 2007 Early Edition of the Proceedings of the National Academy of Sciences, may lead to new treatments for obesity and diabetes. The two new studies are titled- T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1 and Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.

This work may explain why current artificial sweeteners may not help with weight loss, and may lead to the production of new non-caloric sweeteners to better control weight, said Dr. Margolskee. Sensing glucose in the gastrointestinal tract is the first step in regulating blood sugar levels. Having discovered the identity of the guts sweet receptors may open the way for new treatment options for obesity and diabetes.

How Taste Receptors Work

Prior to this research, the intestinal sugar sensors were unknown. Dr. Margolskee and his colleagues Dr. Josephine M. Egan, Dr. Soraya P. Shirazi-Beechey and Dr. Zaza Kokrashvili reasoned that the sugar sensors of the tongues taste buds might also be there in the gut. Sweet taste in the tongue depends on the taste receptor T1R3 and the taste G protein gustducin.

The small intestine is the major site where dietary sugars are absorbed into the body to provide energy, and maintain normal metabolism and homeostasis. If glucose is absorbed in excess obesity may occur. T1R3 and gustducin, critical to sweet taste in the tongue, are also expressed in specialized taste cells of the gut where they sense glucose within the intestine.

Carbohydrate ingested from meals & beverages breaks down into glucose, which stimulates the sweet-sensing proteins in these gut taste cells. Activating the sweetsensing proteins of the gut taste cells promotes secretion of glucagon-like peptide-1 (GLP-1), an intestinal hormone that plays a key role in promoting insulin secretion and regulating appetite.


'/>"/>

Contact: Mount Sinai Newsroom
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related biology news :

1. Childrens taste sensitivity and food choices influenced by taste gene
2. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
3. Bad aftertaste? New sensory on/off switch may cure bane of artificial sweetener search
4. Bitter or sweet? The same taste bud can tell the difference
5. Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods
6. Living taste cells produced outside the body
7. Great (taste) expectations: Study shows brain anticipates taste, shifts gears
8. Sweet water taste paradoxically predicts sweet taste inhibitors
9. How taste response is hard-wired into the brain
10. Variation in bitter-taste receptor gene increases risk for alcoholism
11. Scientists solve sour taste proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight Medical ... to the healthcare market. The company's primary focus is on new product introductions, ... strategies that are necessary to help companies efficiently bring their products to market. ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
Breaking Biology Technology: