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Your first hug: How the early embryo changes shape
Date:11/25/2013

In research published today in Nature Cell Biology, scientists from the EMBL Australia research team based at Monash University's Australian Regenerative Medicine Institute (ARMI) have revealed new insights into how cells organise and form an early mammalian embryo.

In an early mammalian embryo, just 8-cells large, the roundish cells do something they had never done before something that would determine whether the embryo survived or failed. They change their shape. The cells become elongated and compacted against each other, before returning to their rounded shape and dividing again and again.

When compaction does not occur, embryos tend not to survive. And the timing of compaction has been linked to success in IVF (in vitro fertilisation) treatments. But how did these young, seemingly featureless cells undertake this vital shaping process?

Researchers Dr Nicolas Plachta, Dr Juan Carlos Fierro-Gonzlez and Dr Melanie White have found a new mechanism controlling the process. The team used live imaging technology and microinjected fluorescent markers to capture the action in vivid images and video.

"Our images reveal arm-like structures called filopodia appearing on the outer membrane of some cells during the 8-cell stage, and it is these filopodia that are responsible for contorting cell shape, and forming the embryo's first tissue-like layers," Dr Fierro-Gonzlez said.

"For the first time, we have been able to watch as filopodia reach out and grab neighbouring cells, pulling them closer and elongating the cell membranes. We think that this enables the cells to effectively compact, as their new non-rounded shape makes the most of the available space."

But the role of filopodia was made clearer upon seeing what happened next.

"We then saw the filopodia retract as they released their grip on neighbouring cells, allowing them to return to a somewhat rounded shape before they continued on their journey of cell division," Dr Fierro-
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Contact: Courtney Karayannis
courtney.karayannis@monash.edu
61-399-034-841
Monash University
Source:Eurekalert

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