Navigation Links
Your body recycling itself -- captured on film
Date:9/13/2010

This release is available in French.

Our bodies recycle proteins, the fundamental building blocks that enable cell growth and development. Proteins are made up of a chain of amino acids, and scientists have known since the 1980s that first one in the chain determines the lifetime of a protein. McGill researchers have finally discovered how the cell identifies this first amino acid and caught it on camera.

"There are lots of reasons cells recycle proteins fasting, which causes loss of muscle, growth and remodeling during development, and normal turnover as old proteins are replaced to make new ones," explained lead researcher, Dr. Kalle Gehring, from McGill's Department of Biochemistry. "One way that cells decide which proteins to degrade is the presence of a signal known as an N-degron at the start of the protein. By X-ray crystallography, we discovered that the N-degron is recognized by the UBR box, a component of the cells' recycling system." The powerful technique can pinpoint the exact location of atoms and enabled the team to capture an image of the UBR box, providing insight to this incredibly tiny yet essential part of our bodies' chemical mechanics.

Aside from representing a major advance in our understanding of the life cycle of proteins, the research has important repercussions for Johanson-Blizzard syndrome, a rare disease that causes deformations and mental retardation. This syndrome is caused by a mutation in the UBR box that causes it to lose an essential zinc atom. Better understanding of the structure of the UBR box may help researchers develop treatments for this syndrome.


'/>"/>

Contact: Maria Naso
maria.naso@mcgill.ca
514-398-1076
McGill University
Source:Eurekalert  

Page: 1

Related biology news :

1. Scientists concerned about environmental impact of recycling of e-waste
2. Opening the gate to the cells recycling center
3. Researchers identify a new gene involved in autophagy, the cellular recycling program
4. TECNALIA uses artificial vision to improve recycling of electronic scrap metal
5. A window that washes itself?
6. No longer a gray area: Our hair bleaches itself as we grow older
7. Biodiversity itself begets a species cascade, researchers say
8. Scientists discover how deadly fungus protects itself
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. By putting a ring on it, microparticles can be captured
11. Caught on tape: Muscle stem cells captured on video by MU researcher
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Your body recycling itself -- captured on film
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/17/2015)... BURNABY, Canada , April 17, 2015 /PRNewswire/ ... projects, growing security concerns, and technological advancement to ... Arabia until 2020   ... " Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric ... is projected to register growth at CAGR ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... . The good chemical and ecological status of water ... to be attained in Germany by 2015. This is the conclusion ... in northern Germany - the Elbe, Weser, Aller and Ems - ... the University of Koblenz-Landau, the Helmholtz Centre for Environmental Research - ...
... (USDA) aerial photography survey of 38,000 wildfire-burned acres in ... evidence that the invasive leafy spurge weed is displacing ... a rangeland specialist with the Agricultural Research Service (ARS) ... survey using a technique he developed called Very Large ...
... Ariz.-Arizona State University (ASU) and China,s Sun Yat-Sen ... at developing early and predictive diagnostics to improve ... Nobel Laureate, Leland Hartwell, PhD, and Chief Scientist ... spearheaded the agreement with Dr. Jianping Wang, Director ...
Cached Biology News:Poor outlook for water quality in Germany 2Digital cameras open new view of America's West 2ASU and China's Sun Yat-Sen University to develop early diagnostics against colorectal cancer 2ASU and China's Sun Yat-Sen University to develop early diagnostics against colorectal cancer 3
(Date:5/4/2015)...   St. Jude Children,s Research Hospital ... for finding genetic alterations that play an important ... identify with whole-genome sequencing. The findings appear today ... The tool is an algorithm called ... Tree in Next Generation Sequencing. ...
(Date:5/4/2015)... May 4, 2015 /PRNewswire/ - The Fight Against ... pleased to announce the formation of Turnstone Biologics ... treatments for cancer that harness the patient,s own ... unique collaboration between the Children,s Hospital of ... McMaster University, the Ontario Institute for Cancer Research ...
(Date:5/4/2015)... 4, 2015 China Cord Blood Corporation (NYSE: ... China,s leading provider of cord blood collection, ... storage services, today announced that the Company has been ... Hong Kong listed company and ... an agreement (the "Agreement") to purchase the Company,s outstanding ...
(Date:5/4/2015)... Wheaton, Illinois (PRWEB) May 04, 2015 ... treatment options for patients with arm and hand ... rehabilitation exoskeleton at its Oakbrook Terrace network site. ... foundation, the Armeo®Spring is a highly-regarded treatment option ... In acquiring the Armeo®Spring, Marianjoy becomes one of ...
Breaking Biology Technology:Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2
... Cambridge Research &,Instrumentation (CRi) announced today that ... of allowance for their patent application number,10/669,101, for ... patent covers the use of multispectral imaging combined,with ... of,fluorophores in a living mammal. The unmixing of ...
... Nabi,Biopharmaceuticals (Nasdaq: NABI ) today announced that Dr. ... in the BMO,Capital Markets Focus on Healthcare Conference to ... in New York, NY. Dr. Hudson,s,presentation at the conference ... Dr. Hudson will present a company overview including ...
... VIRGINIA BEACH, Va., Nov. 28 LifeNet ... a strategic,partnership with IMS (Integrated Medical Systems ... software tools for LifeNet,Health customers, improving the ... calls for the development, marketing, distribution, and,support ...
Cached Biology Technology:US Patent and Trademark Office Allows CRi's Patent Application for Spectral Imaging of Deep Tissue 2Nabi Biopharmaceuticals to Present at the BMO Capital Markets Focus on Healthcare Conference 2LifeNet Health and IMS Announce Partnership 2
... chemical fumes, allowing safe indoor ... filters remove most organic contaminants. ... flow speed = 100 fpm ... air speed monitor, quick-release filter/blower ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... These versatile enclosures are ... nitrogen or other process ... low-humidity environment. HEPA filtration, ... ionization modules also available, ...
... new Hummingbird has the ability to quickly and ... makes it a perfect candidate for inclusion in ... OCX interface supplied with all the Cartesian products ... Hummingbirds ability to copy plates in seconds ...
Biology Products: