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Young rats given polyphenols show less endothelial function deterioration with aging
Date:1/31/2011

believe that interventions to improve endothelial function (such as the consumption of red wine or other sources of polyphenols) should begin earlier in life to slow down the endothelial dysfunction that occurs with ageing. This study in rats tends to support such a belief.

The present study in rats found that the administration of red wine polyphenols protected against ageing-induced endothelial dysfunction. As stated by the authors: "The present findings indicate that regular intake of RWPs in the drinking water starting at young age (16 week-old) prevented the ageing-related endothelial dysfunction most likely by reducing the excessive oxidative stress in the arterial wall." They suggest an important role of NADPH oxidase and possibly also the angiotensin system in the abnormal vascular response in ageing. Their study showed that, "RWPs intake had also a physiological beneficial effect since it improved the physical exercise capacity of old rats."


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Contact: R. Curtis Ellison
ellison@bu.edu
508-333-1256
Boston University Medical Center
Source:Eurekalert

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