Navigation Links
Young rats given polyphenols show less endothelial function deterioration with aging
Date:1/31/2011

The endothelium is the inner lining of our blood vessels and normal functions of endothelial cells include enabling coagulation, platelet adhesion and immune function. Endothelial dysfunction is associated with reduced anticoagulant properties and the inability of arteries and arterioles to dilate fully.

The gradual decrease in endothelial function over time is a key factor in the development of diseases associated with ageing, especially cardiovascular disease (CVD). Many epidemiologic studies suggest protection against CVD from moderate intake of alcoholic beverages, especially those rich in antioxidants, such as red wine, which is high in polyphenols (RWPs).

This study examined whether intake of red wine polyphenols (RWPs), a rich source of natural antioxidants, prevents ageing-related impairment of vascular function and physical exercise capacity. Vascular reactivity from 12, 20 and 40 week-old rats was assessed in organ chambers. Rats received from week 16 to 40 either solvent, RWPs or the antioxidant and NADPH oxidase inhibitor, apocynin. RWPs and apocynin improved the endothelial dysfunction, normalized oxidative stress and the expression of the different proteins. RWPs also improved ageing-related decline in physical exercise. Thus, intake of RWPs protects against ageing-induced endothelial dysfunction and decline in physical performance. These effects likely involve the ability of RWPs to normalize oxidative stress and the expression of proteins involved in the formation of NO and the angiotensin II pathway.

International Scientific Forum on Alcohol Research members thought that this was an excellent paper, as it begins to delve into mechanisms by which polyphenols improve health. A mechanism is addressed and results are consistent with the working hypothesis of a specific interaction between polyphenols and peculiar enzymes. There is a satisfying agreement between basic mechanisms and pathophysiology. Some scientists believe that interventions to improve endothelial function (such as the consumption of red wine or other sources of polyphenols) should begin earlier in life to slow down the endothelial dysfunction that occurs with ageing. This study in rats tends to support such a belief.

The present study in rats found that the administration of red wine polyphenols protected against ageing-induced endothelial dysfunction. As stated by the authors: "The present findings indicate that regular intake of RWPs in the drinking water starting at young age (16 week-old) prevented the ageing-related endothelial dysfunction most likely by reducing the excessive oxidative stress in the arterial wall." They suggest an important role of NADPH oxidase and possibly also the angiotensin system in the abnormal vascular response in ageing. Their study showed that, "RWPs intake had also a physiological beneficial effect since it improved the physical exercise capacity of old rats."


'/>"/>

Contact: R. Curtis Ellison
ellison@bu.edu
508-333-1256
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. 7 CAMH scientists win Young Investigator awards focused on breakthrough research
2. Young people with asthma run a greater risk of developing caries
3. American Association of Anatomists announces young investigator award winners
4. Young female chimpanzees appear to treat sticks as dolls
5. Program for young students increases interest in college attendance and medical careers
6. Study shows young, unsupervised children most at risk for dog bites
7. Discus fish parent young like mammalian mothers
8. Stephan Grill wins the 2011 Paul Ehrlich Prize for Young Researchers
9. DFG awards 4 young scientists 2010 Bernd Rendel Prize
10. Women: Hope to marry young? Head to Alaska, steer clear of Alabama
11. Energy drinks may give young sports teams an edge, study says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... February 7, 2017 Ipsidy Inc. ... Corporation [OTC: IDGS], ("Ipsidy" or the "Company") a provider ... processing services, is pleased to announce the following changes ... Effective January 31, 2017, Philip D. Beck ... CEO and President.  An experienced payment industry professional and ...
(Date:2/3/2017)... , Feb. 3, 2017  Texas Biomedical Research Institute announced ... Larry Schlesinger as the Institute,s new President and ... effective May 31, 2017. He is currently the Chair of ... the Center for Microbial Interface Biology at Ohio State University. ... the new President and CEO of Texas Biomed," said Dr. ...
(Date:2/2/2017)... Feb. 2, 2017   TapImmune, Inc. ... company specializing in the development of innovative peptide ... of cancer and metastatic disease, announced today it ... manufacturing of a second clinical lot of TPIV ... receptor alpha. The manufactured vaccine product will be ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... MONTREAL , February 18, 2017 ... von intrazellulären Zytokinen bei adoptiven Zelltherapie-Studien, Poster legt metaproteomische ... ... Biosciences Inc. heute bekanntgab, wird Dr. Yoav Peretz ... Methoden in der Entwicklung von Assays zum Nachweis intrazellulärer ...
(Date:2/18/2017)... , Feb 17, 2017 Research and Markets ... Business Report" report to their offering. ... The report provides separate comprehensive analytics ... , and Rest of World. Annual estimates and forecasts are ... analysis is provided for these markets. Market data and analytics are ...
(Date:2/17/2017)... , Feb. 17, 2017  If only ... tumor had a mutation-conferring resistance to chemotherapy, thousands ... genomics research has focused on finding these mutations ... even from circulating tumor DNA in blood — ... oncology therapeutics. Unfortunately, however, detecting these ...
(Date:2/16/2017)... (PRWEB) , ... February 16, 2017 , ... EIT ... framework primarily aimed at the agricultural industry. Pilot studies are about to get under ... through IoT, Big Data and 5G innovations. The concept is expected to be transferred ...
Breaking Biology Technology: