Navigation Links
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Date:2/19/2013

sting that a breakdown product, possibly the haemoglobin pigment, is activating ART to unleash its killing properties," Dr Klonis said.

The possibility of lower drug sensitivity of juvenile parasites was first suspected when the team studied the parasite's digestive system using a revolutionary 3D imaging technique called electron tomography at the Bio21 Institute, University of Melbourne. This initial work was supported by the ARC Centre of Excellence for Coherent X-ray Science.

"In juvenile stages the parasite's digestive system is not yet active, which explains how this stage can avoid the effects of the drug," Professor Tilley said.

"We hope that our findings will provide a guide for changing the timing of the drug treatment regime and developing longer lasting drugs, thereby killing more of the parasites and reducing the development of drug resistance."

The next steps for the team are to try and establish why certain strains are more resistant to ART drug attack than others.

"With the current political will in malaria-affected countries to combat the disease, and funding for implementation of anti-malarial strategies available from the NHMRC, Gates Foundation and other donors, the basic research being done in Australia will be quickly translated into lives saved in the field," added Professor Tilley.


'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
2. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
3. Wiley Prize in Biomedical Sciences awarded to Rosbash, Hall and Young
4. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
5. Giant tobacco plants that stay young forever
6. Strength training improves vascular function in young black men
7. Young Investigator Award winners announced by Anatomy Society
8. Dr. Sanjay Kumar wins STEM CELLS Young Investigator Award
9. New programs draws young artists into science
10. Young gamers offer insight to teaching new physicians robotic surgery
11. Omega-3 intake heightens working memory in healthy young adults
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB ... Good Clinical Practices (GCP) audit to confirm its ... (FDA) regulations. This accomplishment enables HITLAB to conduct ... utilizing the highest principles for patient safety and ... improve global healthcare access, quality, and delivery with ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2
... series will hold a meeting on gene regulatory ... for the development of animal embryos, body parts, ... on four areas -- gene regulatory networks that ... processes; regulatory processes in complex multigenic systems; and ...
... is also available in French . ... involvement today with a $1-million donation to the Thinking ... (MNI), affiliated with McGill University and the McGill University ... to invest in people and expand facilities and services. ...
... in German . Genetically engineered products ... insulin. In future, gene therapy should make it possible to ... that they can address deficiencies to compensate for malfunctions in ... synthetic) DNA must be introduced into host cells, which is ...
Cached Biology News:Building the future -- 21st century nano tools to repair the nervous system 2Cells get sprayed 2
(Date:12/22/2014)... GenomeDx Biosciences today announced that a new ... genomic test for prostate cancer, was able to predict ... radical prostatectomy without adjuvant therapy. Although rapid metastasis in ... tumor genomics to identify these men who have a ... advance. The study has been published online by ...
(Date:12/22/2014)... The American Journal of Hematology/Oncology, a ... editorials addressing developments and pathways related to oncological ... article exploring the role of follicle-stimulating hormone (FSH) ... prostate cancer. , The article references seminal ... there could be a connection to prostate cancer ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced ... , a network of more than 20 contributing ... have fast access to a national pool of frozen ... Fertility Associates of Memphis is the only fertility clinic ... , Dr. William Kutteh , director of Fertility ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that ... Aflatoxin M1 in raw commingled milk is the first ... The peer reviewed report of the validation by Technology ... and Fisheries Research (ILVO-T&V) has been published by the ... most toxic aflatoxin and a known carcinogen, can be ...
Breaking Biology Technology:Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... announced today that Mediasite products are eligible ... country the opportunity to receive the technology at a ... provide discounts between 20 and 90 percent to schools ... technology includes Internet services and access, telecommunications and internal ...
... find a new accessory among their standard travel gear ... new passports, mandated by State Department regulations, will feature ... information featured on the passport's physical page, which the ... passport is a more secure document than the passport ...
... Wave Technologies Inc. has reported financial results for the ... total revenue of $5.2 million and a net loss of ... to total revenue of $10.5 million and net income of ... clinical molecular diagnostic revenue of $4.0 million for the third ...
Cached Biology Technology:Passports to contain RFID chips next year 2
... convenient, and efficient Denatured protein concentration following ... spin column to make handling easy. The ... which were electro-eluted in their Denatured condition. ... high binding capacity fo all pH values. ...
... 220-240 V, is used to resolve 200 kb ... pulsed field gel electrophoresis (PFGE). The system includes ... x 13 cm casting stand with frame and ... screened cap, disposable plug molds, 12 feet of ...
... to knockout or alter genes on the ... Red/ET recombination allows the exchange of genetic information ... manner. An FRT-flanked kanamycin resistance marker cassette is ... to replace a gene on the E.coli ...
... is a state-of-the-art separation system using the ... The Eclipse integrates easily with Wyatts multi-angle ... as well as the Optilab DSP. The ... mass distributions of the particles/molecules separated by ...
Biology Products: