Navigation Links
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Date:2/19/2013

New research has revealed that immature malaria parasites are more resistant to treatment with key antimalarial drugs than older parasites, a finding that could lead to more effective treatments for a disease that kills one person every minute and is developing resistance to drugs at an alarming rate.

University of Melbourne researchers have shown for the first time that malaria parasites (Plasmodium falciparum)in the early stages of development are more than 100 times less sensitive to artemisinin-based drugs, which currently represent a last line of defense against malaria.

The study was conducted by a team led by Professor Leann Tilley and Dr Nectarios (Nick) Klonis from the Department of Biochemistry and Molecular Biology and the Bio21 Institute, and is published in the journal PNAS.

The drug artemisinin (ART) saves millions of lives each year but it is still not clear exactly how it works. Professor Tilley's team developed a novel approach to examine how the parasite responds to drugs under the conditions it encounters in the body. This is important because the malaria parasite takes two days to reach maturity in each cycle but the drug only remains in the bloodstream for a few hours.

"We were surprised to find that juvenile parasites were up to 100 times less sensitive to the drug than mature parasites, and that in some strains the juvenile parasites showed a particularly high degree of resistance. This would result in a large number of juvenile parasites surviving against clinical treatment and helps explain how resistance to drugs develops," Professor Tilley said.

In order to survive in the human body, the parasite must inhabit red blood cells for part of its life cycle, to do this it first digests the cell contents including the haemoglobin protein which carries oxygen in blood.

"We found that the parasite is most susceptible to drug treatment when it is digesting haemoglobin, sugge
'/>"/>

Contact: Nerissa Hannink
nhannink@unimelb.edu.au
61-430-588-055
University of Melbourne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Experimental gene therapy treatment for Duchenne muscular dystrophy offers hope for youngster
2. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
3. Wiley Prize in Biomedical Sciences awarded to Rosbash, Hall and Young
4. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
5. Giant tobacco plants that stay young forever
6. Strength training improves vascular function in young black men
7. Young Investigator Award winners announced by Anatomy Society
8. Dr. Sanjay Kumar wins STEM CELLS Young Investigator Award
9. New programs draws young artists into science
10. Young gamers offer insight to teaching new physicians robotic surgery
11. Omega-3 intake heightens working memory in healthy young adults
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
(Date:11/4/2014)... OXFORD, England , November 4, 2014 ... expansion and vertical market growth   Fuel3D ... it has closed a funding round totaling $6.4 million (£4 ... (£1.6 million) funding secured earlier this year and paves the ... product in 2015. The funding round was led ...
(Date:11/4/2014)... , Nov. 4, 2014   Neurotechnology , ... announced that the latest version of its fingerprint ... Ongoing MINEX evaluation organized by NIST. ... algorithms using the INCITS 378 fingerprint standard template ... in public tenders in the United ...
(Date:11/3/2014)... published in this month,s Proceedings of the ... a recently discovered communication molecule of the body,s immune ... to limit inflammation and the current study reports its ... ability of the immune system to recognize and target ... effect on the immune system now allows us to ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
... about 95 per cent of life was wiped out in ... at the University of Calgary believe they have discovered evidence ... producing ash clouds that had broad impact on global oceans. ... the latest Permian extinction," says Dr. Steve Grasby, adjunct professor ...
... Research is trying to determine whether Alzheimer,s disease might ... new study suggests those efforts could be improved by ... status of elderly people at risk for dementia. ... surveys, asks people to remember what they have eaten. ...
... BUFFALO, N.Y. -- An innovative, educational computing platform developed ... the cloud (remote, high-capacity, scalable servers) is helping UB ... new level. Soon, high-school and middle-school students will benefit ... by UB faculty members with a $250,000 National Science ...
Cached Biology News:Researchers find smoking gun of world's biggest extinction 2Study of nutrition, Alzheimer's links hampered by research approach 2With cloud computing, the mathematics of evolution may get easier to learn 2With cloud computing, the mathematics of evolution may get easier to learn 3With cloud computing, the mathematics of evolution may get easier to learn 4
(Date:11/26/2014)... 2014 Silicon Valley Electronic Data Capture ... RPM Alliance , provider of clinical research and data ... latest addition to its CRO Partnership Program, Clinovo expands ... to India. , “We have found Clinovo’s ClinCapture ... EDC platform which is both user friendly and easy ...
(Date:11/26/2014)... Miles Holder, formerly of Micron Research ... Products team as Sales/Marketing Manager. Mr. Holder has over ... for the graphite industry. , “We are thrilled to ... Dave Trinkley, VP of Market and Product Development for ... in the graphite industry, along with his proven track ...
(Date:11/26/2014)... -- Theravalues Corporation est fier d,annoncer le lancement ... salon Hi Europe 2014 (du 2 au 4 décembre ... Curcumine la plus biodisponible actuellement sur le marché, ... ingrédients approuvés par les règlements européens. ... la racine de curcuma ( Curcuma longa ) ...
(Date:11/24/2014)... 24, 2014  IGI Laboratories, Inc. (NYSE MKT: IG), ... generic pharmaceutical company, today announced it has submitted an ... Food and Drug Administration (FDA), which brings the Company,s ... with eighteen submissions now pending at the FDA. ... of the Company, commented, "Our team here at IGI ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3IGI Laboratories, Inc. Announces ANDA Submission 2
... of Gene Expression (SAGE) is a sequence-based approach to the ... a powerful tool, one of the more comprehensive methods available ... to a profile of the expressed genes. 1 SAGE ... genes expressed in a specimen. The ability to count many ...
... , Overview , ... valuable tool in verifying and improving peptide synthesis. Matrix Assisted Laser Desorption ... rapid, easy to use and requires relatively little maintenance. This work shows ... peptide synthesis. This work was first presented by A. Falick, G. Tarr ...
... Purpose , ... monitoring of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor ... importance of assessing inter-individual and intra-individual metabolism variability. To be ... used to monitor these drugs is fast and easy to ...
Cached Biology Technology:Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 2Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 3Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 4Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 5Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS 2Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS 3A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 2A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 3A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 4
One-step, microplate or cuvet, colorimetric, linear detection range 8 mg/dL to 300 mg/dL. Procedure: 5 min....
dynactin 4, mRNA (cDNA clone MGC:3248 IMAGE:3505855), complete cds...
MOUSE ANTI HUMAN NPM...
RABBIT ANTI HUMAN CHYMOTRYPSIN...
Biology Products: