Navigation Links
York U researchers zero in on protein that may help treat obesity, diabetes
Date:8/9/2011

221.10.254.64

TORONTO, August 9, 2011 A newly-identified protein may hold the key to keeping appetite and blood sugar in check, according to a study by York University researchers.

Suraj Unniappan, associate professor in York's Department of Biology, Faculty of Science & Engineering, is delving into the metabolic effects of a protein called nesfatin-1, abundantly present in the brain. His studies found that rats administered with nesfatin-1 ate less, used more stored fat and became more active. In addition, the protein stimulated insulin secretion from the pancreatic beta cells of both rats and mice.

"[The rats] actually ate more frequently but in lesser amounts," says Unniappan, a member of York's neuroscience graduate diploma program, and a recipient of a Canadian Institutes of Health Research (CIHR) New Investigator Award. "In addition, they were more active and we found that their fatty acid oxidization was increased. In other words, the energy reserve being preferably used during nesfatin-1 treatment was fat. This suggests more fat loss, which could eventually result in body weight loss," he says.

The findings were reported in two recent research articles from Unniappan's laboratory: one published today in Endocrinology and another in March 2011 in Journal of Endocrinology.

Discovered by a research team from Japan in 2006, nesfatin-1 was earlier found to regulate appetite and the production of body fat when injected into the brain of mice and rats.

Unniappan's findings indicate that the protein stimulates insulin secretion from the pancreas, a glandular organ, which contains clusters of cells called the islets of Langerhans. These islets produce several important hormones, including the primary glucose-lowering hormone, insulin.

Previously, Unniappan's team studied mice and found similar results; not only was insulin secretion stimulated, but nesfatin-
'/>"/>

Contact: Melissa Hughes
mehughes@yorku.ca
416-736-2100 x22097
York University
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... A sleep-promoting circuit located deep in the primitive brainstem ... by researchers at Harvard School of Medicine and the ... this is only the second "sleep node" identified in ... necessary and sufficient to produce deep sleep. , Published ... study demonstrates that fully half of all of the ...
(Date:9/18/2014)... a small, icy moon of Uranus, is one of ... solar system. Despite its relatively small size, Miranda appears ... resulted in the formation of at least three remarkable ... , These coronae are visible in Miranda,s southern ... across. Arden corona, the largest, has ridges and troughs ...
(Date:9/18/2014)... New research into the Crimean-Congo hemorrhagic fever virus (CCHFV), ... in humans similar to that caused by Ebolavirus, has ... discovery has the potential to lead to novel targets ... The research, reported in a paper published today in ... scientists at the Texas Biomedical Research Institute and their ...
Breaking Biology News(10 mins):No sedative necessary: Scientists discover new 'sleep node' in the brain 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Research milestone in CCHF virus could help identify new treatments 2
... Md. Scientists have provided new details about how ... the blood cells needed for blood clotting. Katsue Suzuki-Inoue, ... Japan, and colleagues have identified for the first time ... a key role in cancer-induced platelet aggregation. These results ...
... the malaria mosquito uses to zero in on its ... an important step toward developing new and improved repellants ... threat of malaria, generally considered the most prevalent life-threatening ... maxillary palp. It is one of three structures extending ...
... has been developed at the Hebrew University Faculty of ... doctoral research at the university, Dr. Orit Bossi succeeded ... process by countering the breakdown of collagen fibers in ... supervision of Zecharia Madar, the Karl Bach Professor ...
Cached Biology News:How cancer spreads by aggregating platelets 2How cancer spreads by aggregating platelets 3Advance in effort to fight malaria by tricking the mosquito's sense of smell 2Advance in effort to fight malaria by tricking the mosquito's sense of smell 3Antioxidant to retard wrinkles discovered by Hebrew University researcher 2
(Date:9/18/2014)... September 18, 2014 HealthTronics, ... and interventional radiology products and services, announced that ... cryotherapy and cryoablation) versus external beam radiotherapy (EBRT) ... the American Urological Association (MAAUA) Annual Meeting in ... Relative Effectiveness of Cryosurgery and External Beam Radiation ...
(Date:9/18/2014)... 18, 2014 About POCT ... outside a clinical laboratory. It helps in making ... treatments and medication. POCT is gaining popularity due ... diseases such as diabetes, heart disease, and obesity. ... are standardized to minimize errors during the diagnosis ...
(Date:9/18/2014)... /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep Research Report ... "2014 Deep Research Report on Global and China ... Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... and China Acetic Acid Industry" is a professional ... and Global Acetic Acid Market. The ...
(Date:9/18/2014)... September 18, 2014 A novel robotic ... MRI scanner is currently being tested as part of ... Hospital in Boston with the aim of determining if ... make prostate cancer biopsies faster, more accurate, less costly, ... also has the potential to deliver prostate cancer therapies ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2POCT Market in China 2014-2018 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6
... 26 Amedica Corporation, an,orthopedic implants company focused ... U.S. Food and Drug Administration,has granted 510(k) marketing ... Valeo Pedicle Screw system is a low profile ... aimed at allowing surgeons,greater flexibility in the positioning ...
... (Nasdaq: GNTA ) announced today that the ... Warrell, Jr., will provide a,company overview and update ... Annual Healthcare Conference. Genta,s presentation is scheduled,for Wednesday, ... New York Palace Hotel,New York, NY., The ...
... International Limited, a UK,private company, announces MHRA ... based Phase IIB trial of AIMSPRO(R), its ... cross-over study will seek to,detect a beneficial ... Secondary,Progressive Multiple Sclerosis, following open-label observations over,several ...
Cached Biology Technology:Amedica Receives FDA 510(k) Clearance for Valeo(TM) Pedicle Screw System 2Genta Incorporated to Present at Lazard Capital Markets 4th Annual Healthcare Conference 2Genta Incorporated to Present at Lazard Capital Markets 4th Annual Healthcare Conference 3
The external laser upgrade for the Molecular Imager FX adds a 635 nm external laser; the 555 nm long pass filter is replaced with a 605 nm band pass filter to distinguish Cy5 from 532 nm excitable dy...
... DNA Kit is designed for fast and ... plant cells and tissues. The bead beating ... DNA isolation procedures such as CTAB, phenol, ... alcohol precipitation is not necessary - purified ...
The filter 530DF28 for the Molecular Imager FX is a band pass filter for ECL Plus, AttoPhos, SYBR Green, Alexa Fluor 488, FITC, Cy2, and Pro-Q Emerald dyes....
... is a single-step staining method for labeling ... flow cytometry. The kit contains all the ... cells including: positive and negative control cells ... rinsing buffers for processing individual steps in ...
Biology Products: