Navigation Links
Yeast provides genetic clues on drug response
Date:4/10/2014

Why do people respond differently to the same drug? For the first time, researchers have untangled genetic and environmental factors related to drug reactions, bringing us a step closer to predicting how a drug will affect us.

Researchers at the University of British Columbia exposed 6,000 strains of yeast to 3,000 drugs. Yeast strains were modified so their response could be measured. Researchers found that the yeast cells have about 50 main ways in which they react to any drug.

These 50 major response types, known as gene signatures, are like fingerprints that identify all genes and their relevance to a specific drug treatment.

This relatively small number of gene signatures means that it might be possible to eventually use a person's genome to predict their drug response. It could also make it easier to identify more effective therapies.

"This is a starting reference map for understanding variation in drug response," says Guri Giaever, an associate professor in UBC's Faculty of Pharmaceutical Sciences, and a senior author on the study, published today in Science. "It won't be easy but our results suggest it is a solvable problem."

Corey Nislow, also associate professor in the faculty and senior author, says this research will help us better understand how and why some drugs work and others don't.

The findings may also be relevant to cancer treatment. Researchers identified all genes that are essential for growth when cells are chemically stressed. Because cancer is principally a cell that grows out of control, the research points to different strategies to develop new drugs that target these genes.


'/>"/>

Contact: Heather Amos
heather.amos@ubc.ca
604-822-3213
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Strictly yeast
2. FASEB announces 2014 Science Conference: Yeast Chromosome Structure, Replication & Segregation
3. UT Austin engineer converts yeast cells into sweet crude biofuel
4. Special yeast reduce alcohol, improve wine
5. Yeasts lifestyle couples mating with meiosis
6. More efficient production of biofuels from waste with the help of modified yeasts
7. Family trees for yeast cells
8. Yeast we can! New report answers questions on microbiology and beer
9. Yeast protein breaks up amyloid fibrils and disease protein clumps differently
10. The taste and fragrance of orange, vanilla, rose and more — courtesy of bacteria and yeast
11. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2018)... ... November 07, 2018 , ... John Powers, co-founder ... business incubator, is pleased to announce that Gene Tox Lab Solutions, LLC has ... solutions to help healthcare organizations including hospitals and clinics manage their patient population ...
(Date:11/7/2018)... Mass. (PRWEB) , ... November 07, 2018 , ... ... enterprise-class unified communications and collaboration solutions, announced today a modernized and streamlined White ... exclusive website and a newly established reseller administrative control portal. CallTower enhanced ...
(Date:11/6/2018)... ... November 06, 2018 , ... Hematology analyzers can collect vast ... can perform a complete blood count (CBC) and classify multiple cell types, including ... produce improved flagging of abnormal results to aid further microscopic review. , ...
Breaking Biology News(10 mins):
(Date:10/29/2018)... ST. LOUIS (PRWEB) , ... October 29, 2018 , ... ... to healthcare employers nationwide, released its schedule of physician career fairs planned for 2019. ... year and will focus hosting live events in the areas of the country which ...
(Date:10/24/2018)... ... October 22, 2018 , ... ... Bourne, PhD, Director of the Data Science Institute, Stephenson Chair of Data Science, ... Advisory Board. Joining the board of leading scientists and doctors from around the ...
(Date:10/18/2018)... ... October 18, 2018 , ... R3 Stem Cell is ... day regenerative therapy training workshop. The discount is good through November 7th, 2018, with ... stem cell and PRP training workshop includes an amazing useful array of hands on ...
(Date:10/17/2018)... CT (PRWEB) , ... October 17, 2018 , ... ... Implant Center of Connecticut, and his associate, Dr. Michael Kang, are offering current ... therapy and crown lengthening results thanks to the emerging, proven treatment technology known ...
Breaking Biology Technology: