Navigation Links
Yeast missing sex genes undergo unexpected sexual reproduction
Date:5/24/2009

DURHAM, N.C. An emerging form of the pathogenic yeast Candida is able to complete a full sexual cycle in a test tube, even though it's missing the genes for reproduction. And it may also do so while infecting us, according to Duke University Medical Center researchers.

"Sex contributes to the Candida yeast species' evolutionary success," said Joseph Heitman, M.D., Ph.D., director of the Center for Microbial Pathogenesis in the Duke Department of Molecular Genetics and Microbiology and co-author of two papers that tell the story in Nature and Current Biology. "I think the fact that it has a complete sex cycle is likely to play a role in the evolution of drug resistance in this emerging pathogenic yeast species. "

Yeast infections are notoriously hard to treat and yeast are one of the most successful pathogens and commensals in nature, he said. A commensal is an organism that benefits from associating with another organism without affecting the other. Humans are susceptible to three types of yeast infection: thrush (in the mouth and throat), vaginal infection, and a sometimes fatal systemic infection of bloodstream and organs, such as the kidney.

In a paper published online May 24 in Nature, Heitman's team reports that eight Candida species which have a sexual cycle were missing many of the genes related to reproduction found in other species.

"The unrecognized sex cycle could mean we need to develop new treatments to combat what is really happening in humans infected by yeast," said co-author Jennifer Reedy M.D. Ph.D.

With co-author Anna Floyd, Heitman and Reedy explored the question further in a study appearing in the May 14 Current Biology. The major question was: how could the yeast sexually produce spores when they lack so many genes responsible for meiosis, the process of sexual cell division that reduces chromosomes to half their number in the progeny?
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jungle yeast
2. New study reveals the protein that makes phosphate chains in yeast
3. Rhythmic genomics -- the yeast metronome and the walk of life
4. Commercial yeasts upgraded with an enzyme for biofuel production
5. Scientists study full protein content of bakers yeast
6. Genetic differences between yeasts greater than those between humans and chimpanzees
7. Caltech engineers build mini drug-producing biofactories in yeast
8. Gene-environment interaction in yeast gene expression
9. University of Toronto scientists map entire yeast genome
10. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
11. Fossil evidence of missing link in the origin of seals, sea lions, walruses found in Canadian Arctic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... as perching birds, that migrate by night tend to ... to reach their destinations. This seasonal difference in flight ... short migratory flights, says researcher Cecilia Nilsson of Lund ... and Sociobiology . , Nilsson, in a group ... to measure over three years the speed by which ...
(Date:9/2/2014)... last decade in Taiyuan, China, have substantially improved the ... than 50% reduction in costs associated with loss of ... researchers at the Columbia Center for Children,s Environmental Health ... Shanxi Medical University, the Center of Diseases Control and ... of Public Health. , The study is the first ...
(Date:9/2/2014)... people take stress in stride; others are done in ... the molecular mechanisms of this so-called stress gap in ... that could lead researchers to better understand the development ... "Like people, each animal has unique experiences as it ... life experiences can alter the expression of genes, and ...
Breaking Biology News(10 mins):Migrating birds sprint in spring, but take things easy in autumn 2Clean air halves health costs in Chinese city 2Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3
... to provide superior performance in cell culture and addresses ... Stem Cells, Primary Cells, Hybridoma Cells and Chinese Hamster ... Collins, CO September 17, 2009 / b3c newswire / ... of Optiferrin, a high performance, well-defined and animal-free recombinant ...
... fly, is capable of intricate social learning much like ... University. The study, published online today in the journal ... inexperienced female fruit flies, known as Drosophila melanogaster, can learn ... part of an ongoing examination of the evolutionary roots of ...
... first workshop on male infertility in Thessaloniki, Greece "Reproductive ... workshop provides a forum for clinicians and scientists to ... Here some of the new research findings that fertility ... Nature versus Nurture: Male reproductive disorders ...
Cached Biology News:InVitria Successfully Completes Beta Testing and Announces Commercial Launch of Optiferrin for Mammalian Cell Culture 2Pesky fruit flies learn from experienced females: Study 2
(Date:9/2/2014)... for detailed studies of what happens on the surface ... among other applications. A group of researchers from Lund ... membranes form across a large number of vertical nanowires, ... interior of a cell and its surroundings takes place ... layer that holds the cell together and that largely ...
(Date:9/2/2014)... Sept. 2, 2014  TransCelerate BioPharma Inc. ("TransCelerate") ... approach for protecting personal data in Clinical Study ... and others. The document describes an approach to ... CSRs and other related clinical trial documents, and ... goal of the TransCelerate CSR Redaction approach is ...
(Date:9/2/2014)... Orexigen Therapeutics, Inc. (Nasdaq: OREX ... Office (PTO) has issued a patent related to NB32, ... NB32 is a fixed-dose combination of naltrexone sustained release ... 8,815,889 claims methods for treating insulin resistance using a ... 2024. If NB32 is approved for use in ...
(Date:9/2/2014)... GUELPH, ON , Sept. 2, 2014 /PRNewswire/ - BIOREM Inc. ... orders totalling $2.1 million. The orders consist of three large ... Canada . "These orders are consistent ... ," said Peter Bruijns , President and CEO. "After ... control market, we are now beginning to see sales growth. ...
Breaking Biology Technology:Nano-forests to reveal secrets of cells 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 2Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 4
... Pharmaceuticals, Inc. (NYSE Amex: AEN ), a ... for serious illnesses, announced today that it received approval at ... name to Synthetic Biologics, Inc. It is expected that ... name and stock ticker symbol, "SYN", effective as of ...
... of British Columbia professor has developed a new class of ... loss of consciousness in rats, and which are now ... "petit mal seizures," are a symptom of epilepsy, most commonly ... but dazed. The seizures, arising from a flurry of high-frequency ...
... 2012  ERT (NASDAQ: ERT ), a global ... devices to biopharmaceutical sponsors and Contract Research Organizations (CROs), ... to further elevate its market and thought leadership position. ... months, web traffic to ERT,s website increased by 41% ...
Cached Biology Technology:New drugs show promise for preventing 'absence seizures' in children: UBC research 2ERT Launches New Website to Support Significant Commercial Growth 2
... automated bioresearch: Developed for a wide ... on decades of experience in Luminescence ... bioresearch • Holographic gratings for reduced ... ease-of-use • Pulsed Xenon lamp reduces ...
... complete enterprise microarray informatics platform for microarray data ... once and use it forever without paying ongoing ... Acuity has all the analysis tools you ... from quality control statistics and normalization, all the ...
... precise 96 and 384-well transfers in a ... 200ul disposable tips, the 96 channel parallel ... across a volume range from 1-200uls. The ... that enable indexing into 384 well plates, ...
... the ideal instrument for budget-conscious labs that want ... Get Applied Biosystems proven PCR performance ... space without sacrificing results. Enhance productivity ... You Can Afford The Applied Biosystems ...
Biology Products: