Navigation Links
Yeast missing sex genes undergo unexpected sexual reproduction
Date:5/24/2009

DURHAM, N.C. An emerging form of the pathogenic yeast Candida is able to complete a full sexual cycle in a test tube, even though it's missing the genes for reproduction. And it may also do so while infecting us, according to Duke University Medical Center researchers.

"Sex contributes to the Candida yeast species' evolutionary success," said Joseph Heitman, M.D., Ph.D., director of the Center for Microbial Pathogenesis in the Duke Department of Molecular Genetics and Microbiology and co-author of two papers that tell the story in Nature and Current Biology. "I think the fact that it has a complete sex cycle is likely to play a role in the evolution of drug resistance in this emerging pathogenic yeast species. "

Yeast infections are notoriously hard to treat and yeast are one of the most successful pathogens and commensals in nature, he said. A commensal is an organism that benefits from associating with another organism without affecting the other. Humans are susceptible to three types of yeast infection: thrush (in the mouth and throat), vaginal infection, and a sometimes fatal systemic infection of bloodstream and organs, such as the kidney.

In a paper published online May 24 in Nature, Heitman's team reports that eight Candida species which have a sexual cycle were missing many of the genes related to reproduction found in other species.

"The unrecognized sex cycle could mean we need to develop new treatments to combat what is really happening in humans infected by yeast," said co-author Jennifer Reedy M.D. Ph.D.

With co-author Anna Floyd, Heitman and Reedy explored the question further in a study appearing in the May 14 Current Biology. The major question was: how could the yeast sexually produce spores when they lack so many genes responsible for meiosis, the process of sexual cell division that reduces chromosomes to half their number in the progeny?

By examining and defining the structure and functions of the mating-type genes in yeast, Reedy learned that forms of Candida yeast undergo meiosis but generate offspring of several types. About two-thirds have the classic 50:50 division of chromosomes from the split parent cell, but a third of them have an extra chromosome or even double copies of all chromosomes.

"What we found is that the sexual cycle has a new way to create genetic diversity, and it provides a unique vantage point from which we can explore the mechanisms of sexual reproduction," Reedy said. "This provides a new way to study sexual reproduction and how chromosomal abnormalities arise."

Heitman said that Candida's meiosis without meiotic genes may be what gives rise to the progeny with unusual numbers of chromosomes. "Or maybe the genes were lost for a reason, to provide a route to genetic diversity," Heitman said. "Or maybe these differing types of progeny are the unfortunate consequence of undergoing meiosis without the machinery that species normally have when they reproduce sexually."

Humans, too, have their share of oddly paired chromosomes. "Experts estimate that about 10 to 30 percent of human eggs or fusion products may be aneuploid, with chromosomes from mother and father not paired exactly one to one, but the great majority of those fusions of sperm and egg don't make it to the implantation and pregnancy stage," Reedy said. "That's why it is important to find models like this, so that we may shed light on related human conditions."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. Jungle yeast
2. New study reveals the protein that makes phosphate chains in yeast
3. Rhythmic genomics -- the yeast metronome and the walk of life
4. Commercial yeasts upgraded with an enzyme for biofuel production
5. Scientists study full protein content of bakers yeast
6. Genetic differences between yeasts greater than those between humans and chimpanzees
7. Caltech engineers build mini drug-producing biofactories in yeast
8. Gene-environment interaction in yeast gene expression
9. University of Toronto scientists map entire yeast genome
10. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
11. Fossil evidence of missing link in the origin of seals, sea lions, walruses found in Canadian Arctic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ) ... "Global Facial Recognition Market 2016-2020" report ... ) has announced the addition of the ... report to their offering. --> ... announced the addition of the "Global ...
(Date:2/3/2016)... Vigilant Solutions announces today that the ... Missouri solved two recent hit-and-run cases with ... Vigilant Solutions. Brian Wenberg explains, "I ... was walking out of a convenience store and witnessed an elderly male back ... striking his vehicle and leaving the scene.  In his ...
(Date:2/2/2016)... Checkpoint Inhibitors for Cancer – Explore ... you interested in the future of cancer drugs? ... Visiongain,s report gives those predictions to 2026 at ... Avoid falling behind in data or losing ... those emerging cancer therapies can achieve. There you ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... R&D program for the development of future natural products for ... research and development center in Israel ... Stockton has a variety of products adapted ... active in more than 35 counties worldwide. ... flagship product Timorex Gold ® is used to control ...
(Date:2/5/2016)... 2016 ATCC, the premier global biological materials ... medical and life science researchers that are working to ... CDC website . --> ... is a single-stranded RNA virus of the Flaviviridae family, ... and Chikungunya Viruses. Zika virus is transmitted to humans ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf Media Inc ., ... interactive FDA compliance training course, Writing Effective SOPs (Standard ... interactive course on Morf Playbook—now conveniently available on smartphones and PCs--provides step by ...
(Date:2/4/2016)... 2016 Beike Biotechnology, the Shenzhen ... a ceremony in late 2015 to mark their successful ... 2016. --> --> ... Personalized Cell Therapy" was hosted by the Shenzhen Cell ... subsidiaries of Beike Biotechnology Co., Ltd. ...
Breaking Biology Technology: