Navigation Links
Yale study identifies possible bacterial drivers of IBD
Date:8/28/2014

Yale University researchers have identified a handful of bacterial culprits that may drive inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis, using patients' own intestinal immune responses as a guide.

The findings are published Aug. 28 in the journal Cell.

Trillions of bacteria exist within the human intestinal microbiota, which plays a critical role in the development and progression of IBD. Yet it's thought that only a small number of bacterial species affect a person's susceptibility to IBD and its potential severity.

"A handful of bad bacteria are able to attain access to the immune system and get right at the gut," said Richard Flavell, the Sterling Professor of Immunobiology at the Yale School of Medicine. "If you look at the bacteria to which we have made an immune response, you can begin to find these bad actors."

Flavell's research team focused on antibody coatings on the surface of bacteria. In particular, Yale researchers looked at bacteria with high concentrations of an antibody coating called Immunoglobulin A (IgA).

"The coating is our body's attempt to neutralize the bacteria," Flavell said. "It binds to the bad bacteria. We only make these IgA responses to a limited number of organisms."

He and his team confirmed a correlation between high levels of IgA coating and inflammatory responses in the human intestine. To do this, the team collected "good" and "bad" bacteria from a small group of patients and transplanted them into mice. In healthy mice, there was no influence on intestinal inflammation; in mice with induced colitis, those with the suspected "bad" bacteria showed signs of excessive inflammation and other IBD symptoms.

Flavell warned that more research is necessary to learn how many bacterial species fall into the "bad" category and whether those populations are common to all IBD patients or are unique to each patient.

But the study's results indicate that anti-bacterial therapies for IBD are possible, Flavell said. Such anti-bacterial approaches might include highly specific antibiotics, vaccines, and probiotics.

"We believe an anti-bacterial strategy has a place in treating IBD," Flavell said.


'/>"/>

Contact: Jim Shelton
james.shelton@yale.edu
203-432-3881
Yale University
Source:Eurekalert  

Related biology news :

1. Study finds marine protected areas inadequate for protecting fish and ocean ecology
2. Breastfeeding study shows need for effective peer counseling programs
3. Study shows where on the planet new roads should and should not go
4. New study charts the global invasion of crop pests
5. Kessler Foundation researchers publish first study of brain activation in MS using fNIRS
6. More wolf spiders feasting on American toads due to invasive grass, UGA study shows
7. Stop and listen: Study shows how movement affects hearing
8. New study throws into question long-held belief about depression
9. Study calls into question link between prenatal antidepressant exposure and autism risk
10. Study: Earth can sustain more terrestrial plant growth than previously thought
11. WSU flu outbreak provides rare study material
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Yale study identifies possible bacterial drivers of IBD
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Liquid Biotech USA , Inc. ... Research Agreement with The University of Pennsylvania ("PENN") ... patients.  The funding will be used to assess ... outcomes in cancer patients undergoing a variety of ... to support the design of a therapeutic, decision-making ...
(Date:6/24/2016)... , ... June 24, 2016 , ... While the majority ... as the Cary 5000 and the 6000i models are higher end machines that use ... height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
Breaking Biology Technology: