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Yale scientists visualize the machinery of mRNA splicing
Date:4/4/2008

ssociated ions.

According to Pyle, the crystal structure revealed some unexpected features showing two sections that were most implicated as key elements of the active site and strengthening a theory that the process of splicing in humans shares a close evolutionary heritage with ancient forms of bacteria.

Looking to future applications of the work, Pyle said, Group II introns hold promise in the future as agents of gene therapy. A free intron is an infectious element that is special because it targets DNA sites very specifically. We hope that further knowledge of these structures may lead to the development of new genetic tools and therapeutics.


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Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

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Yale scientists visualize the machinery of mRNA splicing
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