Navigation Links
Yale scientists visualize the machinery of mRNA splicing
Date:4/4/2008

New Haven, Conn. Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our genomes; it illuminated a relationship between gene processing in humans and the most primitive organisms by creating the first crystal structure of a crucial self-splicing region of RNA.

Genes of higher organisms code for production of proteins through intermediary RNA molecules. But, after transcription from the DNA, these RNAs must be cut into pieces and patched together before they are ready for translation into protein. Stretches of the RNA sequence that code for protein are kept, and the intervening sequences, or introns, are spliced out of the transcript.

This work, published in Science, highlights a 16-year quest by Anna Marie Pyle, the William Edward Gilbert Professor of Molecular Biophysics & Biochemistry at Yale, and her research team into the nature of group II introns, a particular type of intron within gene transcripts that catalyzes its own removal during the maturation of RNA.

Group II introns are found throughout nature, in all forms of living organisms. Although much has been learned about their structure and how they work through biochemical and computational analysis, until now there have been no high-resolution crystal structures available. The resulting images have provided both confirmation of the earlier work and new information on the three-dimensional structure of RNA and the mechanism of splicing.

One of the most exciting aspects of this work was that we did not need to do anything disruptive to these molecules to prepare them for structural analysis, said Pyle. The molecules showed us their structure, their active site and their activity all in a natural state. We were even able to visualize their a
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Yale scientists visualize the machinery of mRNA splicing
(Date:12/19/2014)... MOUNTAIN VIEW, Calif. , Dec. 18, 2014 /PRNewswire/ ... the publication of a study that pinpoints fine-scale differences ... the United States . Since immigrants ... the United States has served as ... study illuminates how American history and the ongoing mixing ...
(Date:12/17/2014)... Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ... – with the clinical data to back it up," ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... scientists at Columbia,s School of Engineering and Applied Science have ... The American Journal of Human Genetics ( AJHG ) ... to learn more about the history of populations. The authors ... in detail events in recent history, over the past 2,000 ...
... A combined team of scientists from Europe and South ... UK & Naturalis Biodiversity Research Centre , Netherlands), ... Sue Nicolson ( University of Pretoria )) have discovered ... enhanced with a simple cost-effective measure, that involves the ...
... 4, 2012 /PRNewswire-iReach/ -- Greenphire CEO Sam Whitaker spoke ... the implications of the Physician Sunshine Act for the ... technology which streamlines financial reporting required to comply with ... how pharmaceutical, biotech, and medical device companies can use ...
Cached Biology News:Reading history through genetics 2Small patches of native plants help boost pollination services in large farms 2Greenphire CEO Sam Whitaker speaks on Sunshine Act and Clinical Trial Payments 2
(Date:12/24/2014)... SoundConnect’s 2015 ... introduce cutting edge communication technology, provide continued ... platform upgrades. This webinar series demonstrates online ... their quest to leverage web conferencing’s most ... SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our webinars ...
(Date:12/24/2014)... According to Ross Selinger, President of ... Global, the national office market continues to be strong, driven ... evidenced by the third quarter’s surprising 3.9% GDP, unemployment decreasing ... costs have held inflation down and the Fed is keeping ... market remaining soft. , This solid economic news is having ...
(Date:12/24/2014)... 2014 Nashville Fertility Center announced that ... for the American Society for Reproductive Medicine (ASRM), a ... in reproductive medicine. In his new role as ... executive board and will have a voice in furthering ... actively supported ASRM since 1984 when he joined while ...
(Date:12/24/2014)... December 23, 2014 Pipette.com announces their ... Twitter followers can submit their #HolidayInTheLab pictures for a ... lab mates. , For those struggling to think of ... Pipette.com Holiday in the Lab Contest provides the ideal ... followers to send pictures of their chemistree, holiday ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... chips, open-source OS , ,Chippewa Falls, Wis.This is crunch ... than one. , ,As the companys sprawling manufacturing plant here ... final days of its fiscal first quarter, it is hoping ... Altix 3000 family of servers and superclusters, can carry it ...
... We recently had the opportunity to discuss ... more efficient information technology based services - internally and ... to help entrepreneurs with investment funding and health insurance. ... faces as it attempts to limit unsolicited e-mail. ...
... you receive an e-mail from Microsoft and it even looks ... Be Careful! These e-mails appear to be the result ... shares. It is a Mass-Mailing worm which disables processes related ... , ,According to Microsoft, the worm typically spoofs ...
Cached Biology Technology:SGI banking on Altix to pay the freight 2SGI banking on Altix to pay the freight 3WTN Interview with Governor Doyle 2WTN Interview with Governor Doyle 3WTN Interview with Governor Doyle 4WTN Interview with Governor Doyle 5WTN Interview with Governor Doyle 6Fake Microsoft E-Mails Are WORMS in Disguise 2
... Mouse Antibody to Cytokeratin 5 / 6 ... high molecular weight, basic type of cytokeratin ... superficial cell layers of stratified epithelia as ... in mesothelial cells and mesothelioma. Cytokeratin 6 ...
Aldolase A (N-15)...
... Y2 Receptor antiserum This NPY Y2 ... level and is currently being characerized in brain. ... and mouse and appears to work better on ... rat. For full characterizarion in dorsal root ganglion ...
Black Polypropylene 384 Round Well Plate 70/Box...
Biology Products: