Navigation Links
Yale scientists use nanotechnology to fight E. coli
Date:8/30/2007

New Haven, Conn. Single-walled carbon nanotubes (SWCNTs) can kill bacteria like the common pathogen E. coli by severely damaging their cell walls, according to a recent report from Yale researchers in the American Chemical Society (ACS) journal Langmuir.

We began the study out of concerns for the possible toxicity of nanotubes in aquatic environments and their presence in the food chain, said Menachem Elimelech, professor and chair of chemical and environmental engineering at Yale and senior author on the paper. While nanotubes have great promise for medical and commercial applications there is little understanding of how they interact with humans and the environment.

The nanotubes are microscopic carbon cylinders, thousands of times smaller than a human hair that can be easily taken up by human cells, said Elimelech. We wanted to find out more about where and how they are toxic.

This nanoscience version of a David-and-Goliath story was hailed in an ACS preview of the work as the first direct evidence that carbon nanotubes have powerful antimicrobial activity, a discovery that could help fight the growing problem of antibiotic resistant infections.

Using the simple E. coli as test cells, the researchers incubated cultures of the bacteria in the presence of the nanotubes for up to an hour. The microbes were killed outright but only when there was direct contact with aggregates of the SWCNTs that touched the bacteria. Elimelech speculates that the long, thin nanotubes puncture the cells and cause cellular damage.

The study ruled out metal toxicity as a source of the cell damage. To avoid metal contaminants in commercial sources, the SWCNTs were rigorously synthesized and purified in the laboratory of co-author Professor Lisa Pfefferle.

We're now studying the toxicity of multi-walled carbon nanotubes and our preliminary results show that they are less toxic than SWCNTs, Elimelech said. We are also looking at the effects of SWCNTs on a wide range of bacterial strains to better understand the mechanism of cellular damage.

Elimelech projects that SWCNTs could be used to create antimicrobial materials and surface coatings to improve hygiene, while their toxicity could be managed by embedding them to prevent their leaching into the environment.


'/>"/>
Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2016)... CHICAGO , Jan. 11, 2016  higi, ... via nearly 10,000 retail locations, web and mobile, ... than $40 million from existing investors. ... will be devoted to further innovate higi,s health ... app and web portal – including expanding services ...
(Date:1/7/2016)... -- This BCC Research report studies the global as ... identifying newer markets and exploring the expansion of the ... Includes forecast from 2015 to 2020. Use ... the expansion of the present application market for various ... technology, determine its current market size, and estimate the ...
(Date:1/6/2016)... 2016  Varam Capital, a provider of micro-finance inclusion ... deliver advanced authentication solutions to their clients. Varam supplies ... A loan of a few thousand rupees may make ... ability to purchase livestock or equipment for a small ... for a local store. ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... 2016  Discovery Laboratories, Inc. (NASDAQ: DSCO ... KL4 surfactant therapies for respiratory diseases, today announced ... inducement award as a component of employment compensation ... President and Chief Executive Officer.  The award was ... 1, 2016 and granted as an inducement material ...
(Date:2/3/2016)... Ascendis Pharma A/S (Nasdaq: ASND ), ... TransCon technology to address significant unmet medical needs, today ... Leerink Partners Global Healthcare Conference Location: , Waldorf ... 2016 Time:  , 11:55am EST www.ascendispharma.com ... An audio webcast of this event will be posted ...
(Date:2/3/2016)... , Feb. 3, 2016 New ... more than $1 million for researchers in ... on health-related research that demonstrates exciting potential.   ... of funding for the New Jersey Health Foundation Research ... members at these educational institutions— Princeton University, Rutgers ...
(Date:2/3/2016)... ... 2016 , ... ProMIS Neurosciences is currently in the process ... propagating strains of Amyloid beta involved in Alzheimer’s disease. The Company plans to ... on from the first misfolded Amyloid beta target announced on Nov. 12, 2015, ...
Breaking Biology Technology: