Navigation Links
Yale scientists use nanotechnology to fight E. coli
Date:8/30/2007

New Haven, Conn. Single-walled carbon nanotubes (SWCNTs) can kill bacteria like the common pathogen E. coli by severely damaging their cell walls, according to a recent report from Yale researchers in the American Chemical Society (ACS) journal Langmuir.

We began the study out of concerns for the possible toxicity of nanotubes in aquatic environments and their presence in the food chain, said Menachem Elimelech, professor and chair of chemical and environmental engineering at Yale and senior author on the paper. While nanotubes have great promise for medical and commercial applications there is little understanding of how they interact with humans and the environment.

The nanotubes are microscopic carbon cylinders, thousands of times smaller than a human hair that can be easily taken up by human cells, said Elimelech. We wanted to find out more about where and how they are toxic.

This nanoscience version of a David-and-Goliath story was hailed in an ACS preview of the work as the first direct evidence that carbon nanotubes have powerful antimicrobial activity, a discovery that could help fight the growing problem of antibiotic resistant infections.

Using the simple E. coli as test cells, the researchers incubated cultures of the bacteria in the presence of the nanotubes for up to an hour. The microbes were killed outright but only when there was direct contact with aggregates of the SWCNTs that touched the bacteria. Elimelech speculates that the long, thin nanotubes puncture the cells and cause cellular damage.

The study ruled out metal toxicity as a source of the cell damage. To avoid metal contaminants in commercial sources, the SWCNTs were rigorously synthesized and purified in the laboratory of co-author Professor Lisa Pfefferle.

We're now studying the toxicity of multi-walled carbon nanotubes and our preliminary results show that they are less toxic than SWCNTs, Elimelech said. We are also looking at the effects of SWCNTs on a wide range of bacterial strains to better understand the mechanism of cellular damage.

Elimelech projects that SWCNTs could be used to create antimicrobial materials and surface coatings to improve hygiene, while their toxicity could be managed by embedding them to prevent their leaching into the environment.


'/>"/>
Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Scientists Replicate Hepatitis C Virus in Laboratory
7. Scientists detect probable genetic cause of some Parkinsons disease cases
8. Scientists find missing enzyme for tuberculosis iron scavenging pathway
9. Scientists seek answers on what activates deadly anthrax spores
10. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
11. Scientists collaborate to assess health of global environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
(Date:6/23/2016)... -- Amgen (NASDAQ: AMGN ) today announced a ... sciences incubator to accelerate the development of new therapies ... QB3@953 was created to help high-potential life science and ... stage organizations - access to laboratory infrastructure. ... "Amgen Golden Ticket" awards, providing each winner with one ...
(Date:6/22/2016)... Research and Markets has announced the addition ... their offering. The global ... billion in 2013. The market is expected to grow at a ... 2020, increasing from $50.6 billion in 2015 to $96.6 billion in ... forecast period (2015 to 2020) are discussed. As well, new products ...
Breaking Biology Technology: