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Yale scientists show that a microRNA can reduce lung cancer growth
Date:3/20/2008

work demonstrates that let-7 inhibits the growth of lung cancer cells in culture and in lung tumors in mice. They also showed that let-7 can be applied as an intranasal drug to reduce tumor formation in a RAS mouse model lung cancer.

We believe that our studies provide the first direct evidence in mammals, that let-7 functions as a tumor suppressor gene, said Slack. Because multiple cell lines and mouse models of lung cancer were used, it appears that therapeutic application of let-7 may provide benefits to a broad group of lung cancer patients.

This has been a very productive industry-academic collaboration between Yale and Asuragen scientists commented Matt Winkler CEO of Asuragen. This work provides further evidence of the importance of miRNAs in the development of cancer and provides additional support for miRNA replacement therapy as an important component of effective cancer treatment regimens of the future.


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Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

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