Navigation Links
Yale scientists show that a microRNA can reduce lung cancer growth
Date:3/20/2008

New Haven, Conn. A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle.

Cancer afflicts 1.5 million people a year in the United States alone, and lung cancer is the most common and deadly form of cancer worldwide. This study indicates a direct role for a miRNA in cancer progression and introduces a new paradigm of using miRNAs as effective therapeutic agents to treat human cancer.

We believe this is the first report of a miRNA being used to a beneficial effect on any cancer, let alone lung cancers, the deadliest of all cancers worldwide, said senior author Frank Slack, associate professor of molecular, cellular and developmental biology at Yale.

Slacks research group initially discovered the let-7 miRNA in C. elegans, a tiny worm used as a model system for studying how organisms develop, grow and age. They went on to show that in humans, let-7 negatively regulates a well-known determinant of human lung cancers, the RAS oncogene.

In collaboration with scientists at Asuragen, the Slack lab has studied the tumor suppressor activity of this small RNA. Their work revealed that let-7 is commonly present at substantially reduced levels in lung tumors and that reduced levels of let-7 likely contribute to the development of the tumors. These discoveries focused public attention and research efforts to understand the potential use of naturally occurring microRNAs like let-7 to combat cancer.

This new
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Texas A&M scientists say early Americans arrived earlier
2. Scientists find color vision system independent of motion detection
3. Crop scientists discover gene that controls fruit shape
4. Scientists discover how TB develops invincibility against only available treatment
5. Scientists show that streams are critical to preservation of oceanic coastal zones
6. Scientists to discover why flamingos are in the pink of health -- in the poo!
7. Scientists believe photograph depicts wolverine in California
8. Scientists successfully treat new mouse model of inflammatory bowel disease
9. Genes hold the key to how happy we are, scientists say
10. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
11. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Yale scientists show that a microRNA can reduce lung cancer growth
(Date:5/28/2015)... , May 28, 2015 Industry analyst ... a new report titled "Markets for Self-Healing Materials: ... inorganic capsule and vascular systems, biomaterials, relevant shape ... to around $2.7 billion by 2020. ... extensive coverage of smart materials. Other recent n-tech reports ...
(Date:5/27/2015)... CLEVELAND , May 27, 2015 /PRNewswire/ ... in medication safety systems and image documentation ... provider of comprehensive, technologically-advanced automation solutions, is ... art integration. The Codonics® Safe Label System® ... used in conjunction with the Omnicell Anesthesia ...
(Date:5/26/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/p2kc6z/saudi_arabia ... "Saudi Arabia Biometric Systems Market Forecast and Opportunities, ... http://photos.prnewswire.com/prnh/20130307/600769) , ,The biometric systems market in ... grow at over 22% CAGR through 2020 ... surging demand for better biometric technologies in the ...
Breaking Biology News(10 mins):The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 3Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Saudi Arabia Biometric Systems Market Forecast and Opportunities, 2020 with Morpho Safran, ZK Technlogy, and Suprema Dominating 2
... Scientists at the University of Maryland and Tulane University ... that is the first to address the interaction of ... research team simulated how the fish,s flexible body bends, ... around it as well as the muscles inside. Understanding ...
... at the University of Michigan Heath System and their ... one day help guide new treatments for psoriasis, one ... Using cutting-edge methods to peer into the ... the research, published in Nature Genetics, further ...
... agreement between the MPI of Biochemistry and GSK pursues ... research and development work is based on the research ... Biochemistry. He and fellow scientist Mathias Bcker successfully described ... kinases - in connection with the development of type ...
Cached Biology News:Computational model of swimming fish could inspire design of robots or medical prosthetics 2Computational model of swimming fish could inspire design of robots or medical prosthetics 3Four new psoriasis 'hotspots' identified by U-M geneticists 2Cooperation in diabetes research 2
(Date:5/28/2015)... -- Quest Diagnostics Incorporated (NYSE: DGX ), the world,s ... is scheduled to speak at the Jefferies 2015 Global ... the company,s President and CEO, will discuss the company,s ... scheduled for Tuesday, June 2, 2015 at 8:00 a.m. ... live during the conference and will be available to ...
(Date:5/28/2015)... , May 28, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/8h5hs2/animal ) has announced the addition ... Biotechnology - Technologies, Markets and Companies" ... , ,This report describes and evaluates ... veterinary medicine and pharmaceuticals as well ...
(Date:5/28/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/26qndf/nanobiotechnology ... PharmaBiotech,s new report "Nanobiotechnology Applications, Markets ... An increasing use of nanobiotechnology by ... Nanotechnology will be applied at all stages ... optimal delivery to diagnostic applications in clinical ...
(Date:5/28/2015)... , May 27, 2015 Research and ... "Animal Genetics Market by Products, by Testing services ... offering. The global animal genetics market is ... and grow at a CAGR of 8-9% during the ... market is mainly driven by increasing animal protein consumption, ...
Breaking Biology Technology:Quest Diagnostics to Speak at the Jefferies 2015 Global Healthcare Conference 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 2Global Animal Biotechnology Report 2015 - Technologies, Markets and Companies Analysis to 2024 3Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2
... 21 Accuray,Incorporated (Nasdaq: ARAY ), a global ... president and chief executive officer, Euan S.,Thomson, Ph.D., is ... Care Conference at the Pierre Hotel in New York ... (9:30 a.m. PST)., A live webcast of the ...
... 21 Trubion Pharmaceuticals Inc.,(Nasdaq: TRBN ) ... officer and chairman of Trubion, is scheduled to ... Markets Healthcare Investor,Conference to be held at The ... present Nov. 27, 2007, at 2:30 p.m. Interested ...
... 21 Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) ... live during the 19th Annual Piper Jaffray,Health Care ... p.m. Eastern,Time. The presentation will be webcast from ... under the Investor Relations tab at http://www.alexza.com ...
Cached Biology Technology:Accuray Incorporated's CEO to Speak at Piper Jaffray 19th Annual Health Care Conference 2Accuray Incorporated's CEO to Speak at Piper Jaffray 19th Annual Health Care Conference 3Trubion Pharmaceuticals to Present at the Lazard Capital Markets Healthcare Investor Conference 219th Annual Piper Jaffray Health Care Conference to Webcast Alexza's Corporate Presentation 2
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-Dynamin Monoclonal Antibody Description: 100 g Research Focus: neuroscience Storage: -20C Shipping Temperature: 4C...
cysteine and glycine-rich protein 2,...
BKBeta2 potassium channel Antigen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 Accession Number: Q9CZM9...
Biology Products: