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Yale scientists discover new method for engineering human tissue regeneration
Date:5/12/2011

however, a rapid loss of green cells was noted and the cells that developed in the new vessel wall were not green, suggesting that the seeded cells promoted vessel development, but did not turn into vessel wall cells themselves. These findings led to the second part of the study, which tested whether cells produced in the host's bone marrow might be a source for new cells. Scientists replaced the bone marrow cells of a female mouse with those of a male mouse before implanting the graft into female mice. The researchers found that the cells forming the new vessel were female, meaning they did not come from the male bone marrow cells. In the final experiment, researchers implanted a segment of male vessel attached to the scaffold into a female host. After analysis, the researchers found that the side of the graft next to the male segment developed with male vessel wall cells while the side of the graft attached to the female host's vessel formed from female cells, proving that the cells in the new vessel must have migrated from the adjacent normal vessel.

"There's a very good chance that this study will eventually have a major impact on many disorders that afflict humankind," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "These scientists have basically used the body's repair mechanisms to make new tissues through bioengineering. In years to come, starfish and salamanders will have nothing on us!"


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Contact: cmooneyhan@faseb.org
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

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