Navigation Links
Yale scientists create artificial 'cells' that boost the immune response to cancer
Date:2/26/2008

New Haven, Conn. Using artificial cell-like particles, Yale biomedical engineers have devised a rapid and efficient way to produce a 45-fold enhancement of T cell activation and expansion, an immune response important for a patients ability to fight cancer and infectious diseases, according to an advance on line report in Molecular Therapy.

The artificial cells, developed by Tarek Fahmy, assistant professor of biomedical engineering at Yale and his graduate student Erin Steenblock, are made of a material commonly used for biodegradable sutures. The authors say that the new method is the first off-the-shelf antigen-presenting artificial cell that can be tuned to target a specific disease or infection.

This procedure is likely to make it to the clinic rapidly, said senior author Fahmy. All of the materials we use are natural, biodegradable already have FDA approval.

Cancer, viral infections and autoimmune diseases have responded to immunotherapy that boosts a patients own antigen-specific T cells. In those previous procedures, a patients immune cells were harvested and then exposed to cells that stimulate the activation and proliferation of antigen-specific T-cells. The boosted immune cells were then infused back into the patient to attack the disease.

Limitations of these procedures include costly and tedious custom isolation of cells for individual patients and the risk of adverse reaction to foreign cells, according to the Yale researchers. They also pointed to difficulty in obtaining and maintaining sufficient numbers of activated T-cells for effective therapeutic response.

In the new system, the outer surface of each particle is covered in universal
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists unravel the genetic coding of the pea
2. Scientists discover giant fossil frog from hell
3. Advertisers, neuroscientists trace source of emotions in brain
4. Amazon corridors far too narrow, warn scientists
5. Dung happens and helps scientists
6. Priming scientists for successful media interviews
7. Scientists expand understanding of how river carbon impacts the Arctic Ocean
8. Fishermen and UCSB scientists explore ways to improve management of California spiny lobsters
9. Scientists rebuild ancient proteins to reveal primordial Earths temperature
10. Rice scientists make breakthrough in single-molecule sensing
11. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Yale scientists create artificial 'cells' that boost the immune response to cancer
(Date:10/15/2014)... SHELTON, Conn. , Oct. 15, 2014 NXT-ID, Inc. ... a biometric authentication company focused on the growing mobile commerce market ... NASDAQ MarketSite in Times Square on Monday October 13 th . ... with CTO David Tunnel and angel investor Mr. ... Gino Pereira , CEO of NXT-ID thanked his investors and employees ...
(Date:10/14/2014)... Ohio (Oct. 14, 2014)—It,s been millions of years since ... a team led by Ohio University scientists is breathing ... model airflow through dinosaur snouts. The research has important ... only breathe but to enhance the sense of smell ... ,nosy, animals," said Ohio University doctoral student Jason Bourke, ...
(Date:10/14/2014)... 2014 – Scientists from The Scripps Research Institute (TSRI) ... of Health (NIH) to lead an investigation of Lassa ... in Africa. The study aims to understand how Lassa ... while others survive the inflection. , "The ultimate ... of how Lassa fever virus causes disease and develop ...
Breaking Biology News(10 mins):Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... -- The world,s greatest wines are the result of a ... "terroir" -- a term often defined as the vineyard site, soil, ... emphasis on soil science in a symposium on Wednesday, Nov. 4 ... in two parts at the 2009 Annual Meetings of the American ...
... ALFRED, FLLaser labeling of fruit and vegetables is a new, ... is used to label, or "etch" information on produce, thereby ... been licensed for use on a variety of fruits and ... Pacific Rim countries. It has been been approved in Asia, ...
... COConsumer interest in new and diverse types of garlic ... growth of the "local foods" movement, interest in world ... demand for high-quality, locally grown garlic is increasing throughout ... the familiar white, "softneck" garlic (which is most often ...
Cached Biology News:Great wines come from great soils 2Laser etching safe alternative for labeling grapefruit 2Sustainably grown garlic 2Sustainably grown garlic 3
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... 2014 Asterias Biotherapeutics, Inc. (NYSE MKT: ... a Notice of Grant Award (NGA) with the ... 1, 2014.  The NGA provides for the immediate ... of additional grant funds pursuant to the previously ... development of Asterias, product, AST-OPC1. The grant provides ...
(Date:10/20/2014)... , October 20, 2014 , ... (GI) disorders and the delivery of care has revealed ... and worrying inequalities in the provision of healthcare services ... was commissioned by United European Gastroenterology (UEG), have been ... and public awareness of the burden of GI disorders ...
(Date:10/20/2014)... PureTech , a science and technology development ... today the closing of a $55 million growth ... a $120 Billion group of funds. The funding ... forward and to advance new healthcare related products ... really go for the big ideas that can ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6
... Va., April 1, 2008 Champions,Biotechnology, Inc. (OTC ... of advanced preclinical platforms and tumor specific data ... the appointment of new,Board of Directors members and ... prepares to expand its operations., Abba David ...
... April 1 Dr. Roger Kenneth,Hershline, PhD, MD, the ... the not-for-profit public charity CureHIV.us, announces today,that he is ... as the Grand Challenges in Global Health initiative. The,monies ... new drug and treatment,method, LiSAVIOR., This unique new ...
... 3-Minute Press,Show is a daily video program hosted ... Monday through Friday on:, http://www.wallst.net/wallst_tv/3_minute_press_show/index_wallst.php . WallSt.net,s ... executives on their company and most recent press ... insight into a company,s most,recent press release, and ...
Cached Biology Technology:Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 2Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 3Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 4Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 5Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 6Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 7Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 8Cure HIV Reaches Out to Foundation Community to Fund LiSAVIOR 2Featured Stocks on Today's Edition of WallSt.net's 3-Minute Press Show: BFNH, BKYI, RBCL 2Featured Stocks on Today's Edition of WallSt.net's 3-Minute Press Show: BFNH, BKYI, RBCL 3
Request Info...
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Maxi 14 Hybridization Oven. 14 bottle (35 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 medium bottles, pack of mesh, bottle gripper and d...
... The Neural Stem Cell Expansion Kit - Monolayer ... NSC expansion as a monolayer in a ... N-2 Plus Media Supplement, which has been optimized ... et al . (1996) Genes & Development ...
Biology Products: