Navigation Links
Yale researchers unravel mystery of brain aneurysms
Date:11/9/2008

Yale researchers have taken the first critical steps in unraveling the mysteries of brain aneurysms, the often fatal rupturing of blood vessels that afflicts 500,000 people worldwide each year and nearly killed Vice President-elect Joseph Biden two decades ago.

An international team led by Murat Gunel, professor of neurosurgery and neurobiology, and Richard Lifton, Sterling Professor and chair of genetics, and a Howard Hughes Medical Institute investigator scanned the genomes of more than 2,000 individuals suffering from intracranial aneurysms along with 8,000 healthy subjects. They discovered three chromosome segments, or loci, where common genetic variations can create significant risk for ruptured aneurysms, which in turn cause strokes. The subjects came from hospitals in Finland, the Netherlands and Japan, and the results were similar in all groups, indicating that these variations increase risk among diverse human populations.

The findings, reported online in the journal Nature Genetics, could lead to new screening tests to identify hundreds of thousands of people at risk for strokes caused by bleeding and point to new therapies that might be able to strengthen blood vessels in the brain before they burst.

"Even though we have made significant strides in treating unruptured aneurysms, until now we have not had an effective means of identifying the majority of individuals at risk of developing this deadly problem. These genetic findings provide a starting point for changing that equation," Gunel said.

The median age when hemorrhagic stroke occurs is 50 years old, and usually there are no warning signs. In the majority of cases, the resulting strokes cause death or severe brain damage. Without an understanding of the cause of these events, physicians have been left to respond after the fact, once the damage has largely been done. Biden was one of the lucky individuals who survived a ruptured aneurysm with minima
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Montana State University researchers find gene that regulates molds resistance to drugs
2. UC Davis researchers discover Achilles heel in pancreatic cancer
3. Repairing DNA damage: Researchers discover critical process in cancer treatment
4. Corn researchers discover novel gene shut-off mechanisms
5. Researchers at UH explore patient preferences for personalized medicine
6. UC Davis researchers discover a key to aggressive breast cancer
7. Caltech-led researchers find negative cues from appearance alone matter for real elections
8. ASU researchers receive NIH awards for studies of malaria and emergent disease
9. Stanford researchers: Global warming is killing frogs and salamanders in Yellowstone Park
10. Syracuse University researchers discover new way to attack some forms of leukemia
11. Researchers apply systems biology and glycomics to study human inflammatory diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... An international team of researchers led by the University ... rice. , The genetic information will enhance scientists, and ... as well as enable the development of new rice ... environmental stressors to help solve global hunger challenges. , ... Oryza glaberrima ) and evidence for independent domestication," was ...
(Date:7/28/2014)... Reactions among minerals and organic compounds in hydrothermal environments ... they provide energy for the deep biosphere, and may ... little is known about how minerals influence organic reactions. ... have demonstrated how a common mineral acts as a ... need for toxic solvents or expensive reagents. , At ...
(Date:7/28/2014)... mechanism in part of the brain that is key to ... type 1 and type 2 diabetes. The findings are published ... National Academies of Sciences . , "We,ve discovered that ... the hypothalamus known as the ventromedial nucleus sets a ... the blood," said lead author Sabrina Diano, professor in the ...
Breaking Biology News(10 mins):Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Glucose 'control switch' in the brain key to both types of diabetes 2
... are primary producers of ammonia in Houston,s atmosphere, and cars ... according to a new study by researchers at Rice University ... air quality draws minimal oversight from the Environmental Protection Agency ... it means to life in and around the metropolis. ...
... N.Y. DNA and protein sequencing have forever ... of these complex biomolecules has revolutionized drug development, ... evolution and development. But, one major molecule in ... biopolymers. Today, for the first time ...
... A tiny piece of a critical receptor that fuels the ... discovered by University at Buffalo scientists as a promising new ... on the NMDA (N-methyl-D-aspartate) receptor is being published online Oct. ... time that this site has been shown to be useful ...
Cached Biology News:Ammonia gets overdue overview 2Ammonia gets overdue overview 3Uncharted territory: Scientists sequence the first carbohydrate biopolymer 2Uncharted territory: Scientists sequence the first carbohydrate biopolymer 3New drug target for Alzheimer's, stroke is discovered by University at Buffalo scientists 2
(Date:7/29/2014)... White papers by Clinovo ... eClinical technologies, have been published by leading pharmaceutical publications ... long line of white papers by Clinovo to have ... Leader, Pharmaceutical Online, and OpenHealthNews. , At the request ... CTO Marc Desgrousilliers, 'The Five Essentials of Cloud ...
(Date:7/29/2014)... July 29, 2014 ... (LBS) zur Erfassung biologischer Daten in Verbindung ... und patentiert. Das LBS nimmt gleichzeitig mehrere ... des Patienten und sucht erhöhte biologische Aktivitäten ... Potenzial, die Entdeckung und Entwicklung neuer Medikamente ...
(Date:7/28/2014)... SAN DIEGO , July 28, 2014 ... algae cultivation technologies, today announced the appointment of biotechnology ... member of the board of directors. Levine replaces Cynthia ... effective immediately. She will remain chairman of the company,s ... leadership on Sapphire Energy,s mission to deliver commercial scale ...
(Date:7/28/2014)... 2014 “2014 Deep Research ... is a professional and in-depth research report ... report introduces Lubricant basic information, including Lubricant ... and industry overview. This research covers the ... as well as global industry analysis covering ...
Breaking Biology Technology:Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 2PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 4Sapphire Energy Announces New CEO James Levine 2Sapphire Energy Announces New CEO James Levine 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4
... completed phase of the new Children,s,Hospital campus, PITTSBURGH, ... opened its new 10-story, state-of-the-art John G. Rangos,Sr. Research ... new,premier pediatric campus., With more than 300,000 square ... hub of pediatric health research for the region. The ...
... October 29, Rosetta Genomics Ltd. (Nasdaq: ROSG ), ... today its,management will present at Oppenheimer 19th Annual ... Waldorf-Astoria Hotel in New York,City., About MicroRNA, ... small,RNAs that act as master regulators and have ...
... at ImClone Brings Substantial,Oncology Drug Development Expertise, ... ("Senesco" or the "Company") (NYSE Alternext US: SNT),announced ... 55 to its board,of directors. Senesco,s board of ... are independent., (Photo: http://www.newscom.com/cgi-bin/prnh/20081029/NY42202 ), ...
Cached Biology Technology:Opening Dedication of the New John G. Rangos Sr. Research Center at the New Children's Hospital of Pittsburgh of UPMC Campus in Lawrenceville 2Opening Dedication of the New John G. Rangos Sr. Research Center at the New Children's Hospital of Pittsburgh of UPMC Campus in Lawrenceville 3Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 2Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 3Senesco Appoints Harlan W. Waksal, M.D., to Board of Directors 2Senesco Appoints Harlan W. Waksal, M.D., to Board of Directors 3
Polyclonal antiserum raised against conjugated L-isoleucine. Available as antiserum. Amino Acid Antibodies...
Rabbit polyclonal to FOXJ2 ( Abpromise for all tested applications). entrezGeneID: 55810 SwissProtID: Q9P0K8...
Rabbit polyclonal to Oct2, prediluted ( Abpromise for all tested applications). entrezGeneID: 5452 SwissProtID: P09086...
Macrophage-stimulating protein receptor...
Biology Products: