Navigation Links
Yale researchers uncover secrets of salmonella's stealth attack

A single crafty protein allows the deadly bacterium Salmonella enterica to both invade cells lining the intestine and hijack cellular functions to avoid destruction, Yale researchers report in the April 17 issue of the journal Cell.

This evolutionary slight-of-hand sheds new insights into the lethal tricks of Salmonella, which kills more than 2 million people a year.

"In evolutionary terms, this hijacking of cellular machinery to diversify the function of a bacterial protein is mind boggling,'' said Jorge Galan, senior author of the paper and the Lucille P. Markey Professor of Microbial Pathogenesis and Cell Biology and chair of microbial pathogenesis at Yale.

Salmonella causes disease when it takes control of cells lining the intestinal track using its own specialized "nano-syringe" called a type III secretion system. Using this structure, Salmonella injects bacterial proteins that mimic proteins of the host cell and help the pathogen avoid destruction.

The Yale study describes the crucial role a bacterial protein called SopB plays in both Salmonella's forced entry into the cell and its subsequent internal camouflage act. First, SopB works within the external membrane of the cell, called the plasma membrane, to coax the cell into taking in the pathogen, which is then encapsulated within a tiny bubble-like compartment called a vesicle.

SopB's second trick helps prevent the vesicle from being sucked into the lyosome, the organelle within the cell that degrades proteins. In order to accomplish this, SopB must move from the plasma membrane of the cell to the membrane of the internal vesicle containing the pathogen. The Yale group found that Salmonella coaxes the cell to "mark" the SopB protein with a tag called ubiquitin. Addition of this tag makes the bacterial protein recognizable to the cellular machinery that normally moves proteins from the plasma membranes to internal vesicles.

"These studies provide a unique insight into the mechanisms by which this important pathogen causes disease," Galan said. "In addition, this finding may point to a novel paradigm that may be applicable to other important pathogens."


Contact: Bill Hathaway
Yale University

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
(Date:10/27/2015)... BERLIN, Germany , October 27, 2015 ... 2015. SMI,s Automated Semantic Gaze Mapping technology (ASGM) automatically ... SMI,s Eye Tracking Glasses , so that ... Suite BeGaze. --> Munich, Germany ... technology (ASGM) automatically maps data from mobile eye tracking ...
(Date:10/26/2015)... ALTO, Calif. and LAS VEGAS ... Nok Nok Labs , an innovator in modern ... Alliance , today announced the launch of its latest ... first unified platform enabling organizations to use standards-based authentication ... The Nok Nok S3 Authentication Suite is ideal for ...
(Date:10/23/2015)... GOLETA, California , October 23, 2015 ... Instruments (SMI) announce a mobile plug and play integration ... interactive real-world tasks SensoMotoric Instruments (SMI) ... established wearable solutions for eye tracking and physiological data ... with SMI Eye Tracking Glasses 2w and ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Md. , Nov. 25, 2015  PharmAthene, Inc. ... Directors has adopted a stockholder rights plan (Rights Plan) ... net operating loss carryforwards (NOLs) under Section 382 of ... --> PharmAthene,s use of its NOLs ... "ownership change" as defined in Section 382 of the ...
(Date:11/25/2015)... and HOLLISTON, Mass. , Nov. ... (Nasdaq: HART ), a biotechnology company developing bioengineered ... Jim McGorry will present at the LD ... 2015 at 2:30 p.m. PT. The presentation will be ... 30 days. Management will also be available at the ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... and the Organization of Black Aerospace Professionals (OPBAP) has been formalized with the ... other AMA team leaders met with OPBAP leaders Capt. Karl Minter and Capt. ...
(Date:11/25/2015)... San Francisco, CA (PRWEB) , ... November 25, ... ... leading microbial genomics company uBiome, were featured on AngelList early in their initial ... by launching an AngelList syndicate for individuals looking to make early stage investments ...
Breaking Biology Technology: