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Yale researchers explain why cancer 'smart drugs' may not be so smart
Date:5/11/2011

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In their second related study, published online in the current issue of the journal Biochemistry, Maihle and her team show that newly developed reagents to measure sEGFR in blood and other human tissues can detect a second unrelated cell surface protein in tumor cells: alpha-5 integrin.

"This important finding suggests that the naturally occurring sEGFR protein may play a complex role in cell adhesion and migrationtwo cellular processes important in the spread of cancer," said Maihle, who is a member of Yale Cancer Center. "Together these studies demonstrate an unanticipated level of complexity in EGFR signaling and assay development, and suggest new ways to overcome current challenges associated with clinical testing for this important cancer target."


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Contact: Karen N. Peart
karen.peart@hotmail.com
203-432-1326
Yale University
Source:Eurekalert

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