Navigation Links
Yale researchers explain why cancer 'smart drugs' may not be so smart
Date:5/11/2011

Some of the most effective and expensive cancer drugs, dubbed "smart drugs" for their ability to stop tumors by targeting key drivers of cancer cell growth, are not effective in some patients. In two related studies, Yale School of Medicine researchers examined one such driver, the EGF receptor (EGFR), and found that a decoy receptor might be limiting the amount of drug that gets to the intended target.

"We know that smart drugs like Cetuximab are not always effective in the cancer cells they're supposed to target because there are no positive predictive markers for selecting the patients who will benefit from treatment with EGFR-targeted therapies, including EGFR itself," said lead author Nita Maihle, professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences and of Pathology at Yale School of Medicine. "Why would a patient be given an expensive drug if it doesn't work? Our studies provide new insight into this paradoxical EGFR testing conundrum."

In a study published recently in the journal Cancer, Maihle and her team isolated a protein from human blood that looks like EGFR, but is actually a closely related variant called serum sEGFR. They showed that Cetuximab binds equally as well to serum sEGFR as it does to the intended EGFR cancer target.

Those study results showed that sEGFR might act as a decoy receptor in the blood of cancer patients, tying up Cetuximab and therefore limiting the amount of Cetuximab that actually gets to the intended target.

Such limitations may, in part, provide an explanation for the failure of two large phase III clinical trials on Cetuximab in colorectal cancer patients, since serum sEGFR concentrations are highly variable in cancer patients. These studies suggest that serum sEGFR should be measured and considered prior to treatment with Cetuximab. Other research has supported this concept by showing that serum sEGFR concentration changes in response to treatment w
'/>"/>

Contact: Karen N. Peart
karen.peart@hotmail.com
203-432-1326
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Reforesting rural lands in China pays big dividends, Stanford researchers say
2. Chemistry researchers receive patent for new scientific measurement instrument
3. USDA researchers, collaborators sequence genomes of fungi that threaten wheat, poplars
4. Researchers get new view of how water and sulfur dioxide mix
5. OGI genomics researchers awarded $23 million
6. Columbia researchers find green roof is a cost-effective way to keep water out of sewers
7. Einstein researchers find key gene in childhood cancer
8. Researchers show heparan sulfate adjusts functions of growth factor proteins
9. Penn researchers develop technique for measuring stressed molecules in cells
10. Researchers see a picture of threat in the brain: Work may lead to new model of neuroinflammation
11. Researchers join forces to cure deadly childhood disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... TORONTO, June 24, 2014 Some sticky research out ... fight against a certain species of toxic grass fungus: ... this month,s Biology Letters , "Ungulate saliva inhibits ... when applied to red fescue grass (which hosts a ... results in slower fungus growth and less toxicity. , ...
(Date:7/24/2014)... Iyer, O.D., a low vision specialist at The University ... School, has been awarded a grant to help Harris ... eyeglasses, medication or surgery. , Even with corrective lenses, ... best. However, there are a variety of low vision ... help offset their vision loss. , Iyer is using ...
(Date:7/24/2014)... fire hazard in the United States, wildland managers often ... and suppressed trees (ladder fuels). These cuttings and ... low fire danger in order to dispose of the ... pollutants, managers often cover all or part of the ... as agricultural plastic, in order to keep water out. ...
Breaking Biology News(10 mins):Moose drool inhibits growth of toxic fungus: York U research 2UTHealth Dr. Bhavani Iyer awarded low vision grant 2Study gives new perspective on agricultural plastic, debris burning, and air quality 2
... and a half acres of Appalachia have been strip-mined, whole ... and communities devastated. Not exactly a promising place for a ... For his startling and bold proposal to clean-up this ... of Appalachia, John Todd, a research professor in the Rubenstein ...
... drug reverses the brain dysfunction inflicted by a genetic ... of TSC patients also suffer from autism, the findings ... autism. Nature Medicine publishes the findings ... mouse model for TSC, the scientists tested rapamycin, a ...
... the Smithsonian,s National Zoo detected a secondary rise in ... Mei Xiang (may-SHONG) earlier this month. The results from ... believe the hormone rise indicates that it would be ... to a cub or comes to the end of ...
Cached Biology News:Buckminster Fuller takes on big coal 2Buckminster Fuller takes on big coal 3Drug reverses mental retardation caused by genetic disorder 2
(Date:7/24/2014)... 2014 Research and Markets has ... Proteomics Analytical Instruments Market 2014-2018" report to their ... Genomics is the study of the gene and ... structure and functions of proteomes or sets of proteins ... Genomics involves the mapping of genes and DNA sequencing ...
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 ... seven-year contract with the National Institute of Allergy and ... Health, to conduct preclinical development of potential therapies for ... of drugs to treat HIV and AIDS and the ... well as microbicides for preventing sexual transmission of HIV. ...
(Date:7/24/2014)... Francisco, CA (PRWEB) July 24, 2014 ... to be semi-finalists in Livestrong’s Big C Competition. Out ... Health are each headed to the semi-final round. In ... Livestrong’s exclusive three-month accelerator program, complete with mentoring from ... , As part of the angelMD commitment to ...
(Date:7/24/2014)... 2014  Neogen Corporation (Nasdaq: NEOG ) ... potential revenue from new rodenticide research are premature. In ... on July 22, 2014, Neogen,s CEO commented about several ... "It was my intent Tuesday at our ... a new type of rodenticide, but certainly not to ...
Breaking Biology Technology:Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 33 angelMD Startups Make Livestrong Big C Semi-finals 2Neogen comments on SenesTech 2
... Brad Thompson, President,and CEO of Oncolytics Biotech Inc. (TSX: ... Company at the Maxim Group Growth Conference at,2:30 p.m. ... being held at the,Grand Hyatt Hotel in New York., ... is available at, http://www.wsw.com/webcast/maxim/oncy/ on the company,s website ...
... Engineering and Operations Appointed -, CLINTON, N.J., ... appointment of Michael Kennedy as Senior Vice President,Engineering ... responsible for,drug-device technology strategy and development., "Michael,s ... critical care as we continue to advance our ...
... Oct. 2 ,ImpediMed Ltd, a pioneer in ... Inc., a global leader in science-based,nutraceutical products, ... announced an agreement to distribute ImpediMed technology,in ... affiliate, Health,World, Ltd, has been a long-standing ...
Cached Biology Technology:Media Advisory - Oncolytics Biotech Inc. to Present at Maxim Group Growth Conference 2Ikaria Strengthens Executive Leadership Team 2ImpediMed and Metagenics Announce Agreement 2
Form: Ready to use Applications: ELISA...
Form: Ready to use Applications: ELISA...
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble...
2,4,6, Trinitrophenyl hapten is conjugated to lipopolysaccharide (LPS)....
Biology Products: