Navigation Links
Yale discovery suggests protein may play a role in severe asthma
Date:11/14/2007

New Haven, Conn.A protein measured in a simple blood test may be a new biomarker to identify patients with the most serious form of asthma, Yale School of Medicine researchers report today in the New England Journal of Medicine.

Identifying this new biomarker, YKL-40, brings investigators one step closer to a treatment for the nations 2.5 million asthmatics with a severe form of the disease that is difficult to treat, the researchers say.

The studies were done in collaboration with investigators in Wisconsin, France, and at MedImmune Inc.

Asthma is a chronic disease of the lung that affects more than 30 million Americans, among them nine million children. It is characterized by chronic inflammation and structural changes in the airwayssymptoms that are severe in some patients and mild in others. Investigators are trying to find ways to control the inflammation and to understand the variation in severity.

The researchers evaluated serum levels of YKL-40 in 253 adults patients in three asthma and control groups at Yale, the University of Wisconsin, and the University of Paris. The found increased circulating serum levels of YKL-40 in patients with asthma compared to those without disease. In addition, blood levels of YKL-40 correlated with asthma severity, lung function, and thickness of the patients bronchial wall.

The results demonstrate that YKL-40 is significantly elevated in severe asthma, said Geoffrey Chupp, M.D., associate professor of medicine at Yale and the lead author on the study. Having a blood test to characterize asthmatics will be useful in pursuing asthma research and potentially in managing asthma.

He said that research on the biology of YKL-40 should be incorporated into investigations on the pathogenesis of asthma, and additional studies are needed to define the potential role of a YKL-40 blood test in asthma management.

Jack Elias, M.D., professor and chair of medicine, professor of immunobiology, and senior author of the study, said the findings are among the first to define a parameter for asthma that can be assessed with a blood test.

This may allow us to identify a subpopulation of patients with severe asthma and give us insights into the biologic processes that make the disease so severe in these individuals, Elias said. Our studies also have demonstrated that eliminating YKL-40 decreases specific types of tissue inflammationwhich could be of particular benefit to asthmatic patients with an elevated level of this protein.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
8. Misconceptions about Alzheimers varies among races, survey suggests
9. Wasp genetics study suggests altruism evolved from maternal behavior
10. Protein chatter linked to cancer activation
11. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... May 6, 2016 MedGenome will ... for South Asian genome variation, at the Big Data ... Boston, MA.      (Logo: ... of human genetic variation is essential for investigating the ... in individuals from different groups in South ...
(Date:5/6/2016)... 6, 2016 The News Of Biomedical ... "Who Is Telling The Truth, Nature Or Man?" ... [1] The formal recognition of a fundamental omission ... published by a national academy of science with ... is a significant development towards the advancement of ...
(Date:5/6/2016)... According to a new market report ... Group A Streptococcus (GAS) Nucleic Acid (NA) Test Products Market ... 2015 - 2023 ", the Europe ... (NA) test products market was valued at US$ 8.3 Mn ... of 11.6% from 2015 to 2023 to reach US$ 22.3 ...
(Date:5/6/2016)... 2016 Recent studies show that patients no ... medication when treating certain types of pain. With the ... can go right to the source instead of masking ... organization, provides physician training about the benefits of regenerative ... find physicians across the United States ...
Breaking Biology Technology: