Navigation Links
Yale discovery suggests protein may play a role in severe asthma
Date:11/14/2007

New Haven, Conn.A protein measured in a simple blood test may be a new biomarker to identify patients with the most serious form of asthma, Yale School of Medicine researchers report today in the New England Journal of Medicine.

Identifying this new biomarker, YKL-40, brings investigators one step closer to a treatment for the nations 2.5 million asthmatics with a severe form of the disease that is difficult to treat, the researchers say.

The studies were done in collaboration with investigators in Wisconsin, France, and at MedImmune Inc.

Asthma is a chronic disease of the lung that affects more than 30 million Americans, among them nine million children. It is characterized by chronic inflammation and structural changes in the airwayssymptoms that are severe in some patients and mild in others. Investigators are trying to find ways to control the inflammation and to understand the variation in severity.

The researchers evaluated serum levels of YKL-40 in 253 adults patients in three asthma and control groups at Yale, the University of Wisconsin, and the University of Paris. The found increased circulating serum levels of YKL-40 in patients with asthma compared to those without disease. In addition, blood levels of YKL-40 correlated with asthma severity, lung function, and thickness of the patients bronchial wall.

The results demonstrate that YKL-40 is significantly elevated in severe asthma, said Geoffrey Chupp, M.D., associate professor of medicine at Yale and the lead author on the study. Having a blood test to characterize asthmatics will be useful in pursuing asthma research and potentially in managing asthma.

He said that research on the biology of YKL-40 should be incorporated into investigations on the pathogenesis of asthma, and additional studies are needed to define the potential role of a YKL-40 blood test in asthma management.

Jack Elias, M.D., professor and chair of medicine, professor of immunobiology, and senior author of the study, said the findings are among the first to define a parameter for asthma that can be assessed with a blood test.

This may allow us to identify a subpopulation of patients with severe asthma and give us insights into the biologic processes that make the disease so severe in these individuals, Elias said. Our studies also have demonstrated that eliminating YKL-40 decreases specific types of tissue inflammationwhich could be of particular benefit to asthmatic patients with an elevated level of this protein.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
8. Misconceptions about Alzheimers varies among races, survey suggests
9. Wasp genetics study suggests altruism evolved from maternal behavior
10. Protein chatter linked to cancer activation
11. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... ... implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient Recovery (ABNR™) technology at its ... a $24 million plant upgrade to sustainably meet current and future nutrient discharge ...
(Date:5/24/2017)... ... May 24, 2017 , ... Patient ... developed with Wi-Fi connectivity to reduce the amount of wiring in a healthcare ... addition, compact mobile devices including infusion pumps, heart and hypertension monitoring, glucose monitoring, ...
(Date:5/23/2017)... Westminster, Colorado (PRWEB) , ... May 23, 2017 , ... ... amaranth as the most troublesome and difficult to control weed in 12 categories of ... found. , Almost 200 weed scientists across the U.S. and Canada participated in the ...
(Date:5/23/2017)... ... May 22, 2017 , ... ... row in the Aragon Research Globe™ for Corporate Learning, 2017. , Aragon Research ... and market demand, and effectively perform against those strategies. NetDimensions’ ranking as a ...
Breaking Biology Technology: