Navigation Links
Yale develops new animal model for hemophilia A
Date:9/3/2010

Researchers at Yale School of Medicine have developed a new animal model for studying hemophilia A, with the goal of eventually treating people with the disorder. Hemophilia A, a hereditary defect that prevents blood from clotting normally, is caused by a variety of mutations in the factor VIII gene.

Published online in the Journal of Thrombosis and Haemostasis, the study aimed to provide a better understanding of hemophilia A, according to first author and veterinarian Carmen Jane Booth, assistant professor of comparative medicine, and co-director of Mouse Research Pathology at Yale School of Medicine.

Booth and her team studied an inbred colony of rats that lived healthily for many years before spontaneously exhibiting symptoms similar to those of humans with hemophilia A, including hemorrhage, spontaneous bruising, swollen joints, prolonged bleeding from minor wounds and unexplained deaths among pregnant and postpartum rats. The team ruled out environmental factors as being responsible for the bleeding disorder in these rats, showed that it was inherited, and conducted diagnostic tests to identify the specific coagulation factor and underlying genetic defect responsible for the disorder.

The team found that the affected animals had a decreased amount of factor VIII. They sequenced the rat factor VIII cDNA and identified a mutation in this gene that was similar to mutations in some people with severe hemophilia. The factor VIII gene is located on chromosome 18 in rats, in contrast to its location on the X chromosome in mice and humans. "The larger size of the rat and the gene location difference makes the rat a unique model, well suited to developing novel therapies for acquired and hereditary factor VIII deficiencies," said Booth.

When we get a minor cut, bleeding should stop in about 20 to 30 seconds, but in hemophiliacs, the bleeding is prolonged because the blood cannot form or maintain a proper blood clot. This can lead to bruises, injured joints and even life-threatening bleeding from everyday activities. The research team found that treating the affected rats with human recombinant factor VIII corrected their coagulation abnormality and stopped the prolonged bleeding.

"This is the only spontaneous rat model of hemophilia A," said Booth. "Rats bruise and bleed similarly to humans with hemophilia A. Ultimately, we plan to translate this model for use in developing gene therapies and evaluating novel therapeutics for treating people with hemophilia A."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related biology news :

1. Research develops simple recipe for fungus-free horseradish
2. CCNY-led team develops non-toxic oil recovery agent
3. Harvards Wyss Institute develops technology to produce sugar from photosynthetic bacteria
4. ISU researcher develops green, bio-based process for producing fuel additive
5. Military develops multi-purpose green decontaminants for terrorist attack sites
6. CSIRO develops highest-yielding salt-tolerant wheat
7. Tiny gold probes give scientists a sense of how disease develops
8. University of the Basque Country develops system for identifying illnesses in Paraguay
9. New strategy develops 2 prototype drugs against cancer, retinal diseases
10. Scripps research team develops technique to determine ethnic origin of stem cell lines
11. Duke develops nano-scale drug delivery for chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... ... June 19, 2017 , ... ... activities supporting EDETEK’s products including training, implementation, support, and client process and SOP ... role. He has previously held leadership roles for service providers and top-tier pharmaceuticals, ...
(Date:6/19/2017)... ... June 19, 2017 , ... A colony of healthy honey bees is like ... delivering pollen and nectar containing nutrients necessary for growth and survival. Better nutrition gives ... recent indicators point to a decline in honey bee health. Sick and weakened bees ...
(Date:6/16/2017)... Rocky Hill, CT (PRWEB) , ... June 16, 2017 , ... ... of last night’s Entrepreneur Innovation Awards (EIA), held at The LOFT at Chelsea Piers ... their innovative project ideas to a panel of judges for an opportunity to secure ...
(Date:6/15/2017)... ... June 15, 2017 , ... The newest ... artist’s journey through creative experimentation and interdisciplinary collaboration. Feature Creep, a solo exhibition ... An opening reception will be held at EKG, located at 3600 Market Street ...
Breaking Biology Technology: