Navigation Links
Yale University researchers find key genetic trigger of depression
Date:10/17/2010

Yale University researchers have found a gene that seems to be a key contributor to the onset of depression and is a promising target for a new class of antidepressants, they report Oct. 17 in the journal Nature Medicine.

"This could be a primary cause, or at least a major contributing factor, to the signaling abnormalities that lead to depression," said Ronald S. Duman, professor of psychiatry and pharmacology at Yale and senior author of the study.

Scientists have had a difficult time pinning down the cause of depression, which afflicts almost 16 percent of Americans in any given year and carries an annual economic burden of $100 billion.

Symptoms of depression vary widely among individuals. Most now believe that multiple physiological processes are involved in major depressive disorder. That explains why people respond differently to most commonly prescribed antidepressants, which work by manipulating the uptake of the neurotransmitter serotonin. However, as many as 40 percent of depressed patients do not respond to currently available medications, which take weeks to months to produce a therapeutic response.

Duman's team did whole genome scans on tissue samples from 21 deceased individuals who had been diagnosed with depression and compared gene expression levels to those of 18 individuals who had not been diagnosed with depression. They found that one gene called MKP-1 was increased more than two-fold in the brain tissues of depressed individuals.

This was particularly exciting, say the researchers, because the gene inactivates a molecular pathway crucial to the survival and function of neurons and its impairment has been implicated in depression as well as other disorders. Duman's team also found that when the MKP-1 gene is knocked out in mice, the mice become resilient to stress. When the gene is activated, mice exhibit symptoms that mimic depression.

The finding that a negative regulator of a key neuronal signaling pathway is increased in depression also identifies MKP-1 as a potential target for a novel class of therapeutic agents, particularly for treatment resistant depression.


'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Related biology news :

1. Team of chemists produces biodiesel at their university, using used cooking oil as a basis
2. Queens University Belfast lung injury study could save lives in critically ill
3. Unlike us, honeybees naturally make quick switch in their biological clocks, says Hebrew University researcher
4. University of Utah microbubbles clean dirty soil in China
5. Ben-Gurion University of the Negev hosts UNESCO conference on drylands, deserts and desertification
6. Brown University chemists simplify biodiesel conversion
7. New fisheries system will save about $20 million, Iowa State University researchers find
8. Hebrew University research holds promise for development of new osteoporosis drug
9. Auxogyn licenses noninvasive embryo assessment technology from Stanford University
10. Iowa State University researcher examines mosquito gene for new disease response
11. WSJ honors university-created LLC with Innovation Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... Germany , December 15, 2016 ... announced an agreement with NuData Security, an award-winning ... partnership will enable clients to focus on good customer experience, ... protection regulation. ... In order to provide a one-stop fraud prevention suite, ...
(Date:12/15/2016)... ... Markets has announced the addition of the "Global Military Biometrics Market ... the global military biometrics market to grow at a CAGR of 7.5% ... based on an in-depth market analysis with inputs from industry experts. The ... years. The report also includes a discussion of the key vendors operating ...
(Date:12/15/2016)... Dec. 15, 2016  There is much more to ... starting the engine. Continental will demonstrate the intelligence of ... Vegas . Through the combination of the keyless ... and biometric elements, the international technology company is opening ... and authentication. "The integration of biometric elements ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... 18, 2017 , ... LabRoots , the leading provider ... world, was today awarded the "Best Science & Technology Social Networking Service 2016" ... decided upon by a dedicated team of researchers and analysts. , The 2016 ...
(Date:1/19/2017)... , Jan. 18, 2017  Northwest Biotherapeutics, Inc. ... DCVax® personalized immune therapies for operable and inoperable solid ... , Chief Technical Officer of NW Bio, will present ... 19, 2017, at the Hyatt Regency Hotel in ... will chair the session entitled "New Therapeutic Approaches – ...
(Date:1/18/2017)... 2017 According to a new market research report "In ... Disease), & End User (Molecular Diagnostic Laboratories, Academic and Research Institutions) - Global ... 739.9 Million by 2021 from USD 557.1 Million in 2016, growing at a ... ... MarketsandMarkets Logo ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... Clinical Ops Executives 2017 in its continued commitment to the advancement of the ... to discuss current issues related to clinical trial planning and management. , ...
Breaking Biology Technology: