Navigation Links
Xie Lab uncovers molecular machinery related to stem cell fate
Date:6/26/2009

The Stowers Institute's Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and how it is involved in regulating the quality of stem cells through intercellular competition. The work was published today by PNAS Early Edition.

Maintaining the proper balance between stem cell self-renewal and differentiation is critical for normal homeostasis. An imbalance between the two can lead to tissue degeneration and to the development of tumors. It has long been known that the BAM protein is necessary for germline stem cell differentiation, but the specific molecular mechanism underlying BAM function had remained a mystery until now.

Examining the fruit fly ovary, the Xie Lab established that BAM controls stem cell differentiation and competition by interfering with the function of the protein translation initiation factor eIF4A. EIF4A and BAM antagonize each other to regulate the balance between self-renewal and differentiation by promoting proper expression of E-cadherin a molecule crucial to the stem cell's ability to attach to its microenvironment (its niche).

"Our studies contribute to the understanding of stem cell fate control," said Run Shen, Ph.D., Postdoctoral Research Associate in the Xie Lab and lead author on the paper. "Many protein translation initiation factors have been reported to be unregulated in different human cancer tissues, so our study may help to understand how translational initiation factors participate in stem cell misregulation and the development of tumors."

"Our studies have established the role of BAM as a protein translational repressor using biochemical and genetic tests," said Ting Xie, Ph.D., Investigator and senior author on the paper. "Translational control is very important in regulating gene expression. Many genes critical for stem cell development in the fruit fly germline are suggested to be translational regulators, but their exact roles have not been carefully studied. The knowledge generated by this work and the tests we have developed give us great advantage in tackling many additional questions."


'/>"/>

Contact: Marie Jennings
mfj@stowers.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Research uncovers clues to virus-cancer link
2. New genomic technique uncovers coral transcriptome
3. Skin cancer study uncovers new tumor suppressor gene
4. Research uncovers promising target to treat chronic abdominal pain
5. Research uncovers surprising lion stronghold in war-torn central Africa
6. University of Leicester archaeologist uncovers evidence of ancient chemical warfare
7. Case Western Reserve University uncovers genetic basis for some birth defects
8. Research uncovers new steps on pathway to enlarged heart
9. Computational biochemist uncovers a molecular clue to evolution
10. University of Miami scientist uncovers miscalculation in geological undersea record
11. Epigenetic research uncovers new targets for modification enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/30/2017)... 30, 2017   Invitae Corporation (NYSE: ... information companies, today announced that it will report its ... 2017 guidance on Monday, February 13, 2017, and Invitae,s ... at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... briefly review financial results, guidance, and recent developments and ...
(Date:1/24/2017)... , Jan. 24, 2017  It sounds ... baby,s sock that monitors vital signs and alerts ... an infant,s oxygen saturation level drops. But pediatric ... alarm to parents, with no evidence of medical ... devices are marketed aggressively to parents of healthy ...
(Date:1/18/2017)... Md. , Jan. 18, 2017  In vitro ... respect to mergers and acquisitions (M&A), and Kalorama Information ... for such acquisitions have been shifting. Generally, uncertainty in ... and the U.S. has changed the acquisitions landscape. ... has resulted in companies buying partners outside of their ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... , ... February 23, 2017 , ... The Greater ... a new partnership with Compass Research . GGI's mission is to advance global ... to a child in need in honor of each clinical trial volunteer. The vision ...
(Date:2/23/2017)... , Feb. 23, 2017 Aviva ... tools, announced the acquisition of GenWay Biotech Incorporated, ... comprehensive service and product offering for both the ... will facilitate growth and enhance capabilities for both ... and ELISA assays will nicely complement ASB,s objective ...
(Date:2/23/2017)... USA, and CARDIFF, UK (PRWEB) , ... February ... ... international society for optics and photonics , have been named Fellows of the ... significant scientific and technical contributions in the multidisciplinary fields of optics, photonics, and ...
(Date:2/22/2017)... LOS ANGELES, CA (PRWEB) , ... February 22, ... ... company, today announced that is has acquired Kendall Research Systems, LLC ... of Technology (MIT) that develops neural interface technology for research and clinical applications. ...
Breaking Biology Technology: