Navigation Links
Xie Lab uncovers molecular machinery related to stem cell fate
Date:6/26/2009

The Stowers Institute's Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and how it is involved in regulating the quality of stem cells through intercellular competition. The work was published today by PNAS Early Edition.

Maintaining the proper balance between stem cell self-renewal and differentiation is critical for normal homeostasis. An imbalance between the two can lead to tissue degeneration and to the development of tumors. It has long been known that the BAM protein is necessary for germline stem cell differentiation, but the specific molecular mechanism underlying BAM function had remained a mystery until now.

Examining the fruit fly ovary, the Xie Lab established that BAM controls stem cell differentiation and competition by interfering with the function of the protein translation initiation factor eIF4A. EIF4A and BAM antagonize each other to regulate the balance between self-renewal and differentiation by promoting proper expression of E-cadherin a molecule crucial to the stem cell's ability to attach to its microenvironment (its niche).

"Our studies contribute to the understanding of stem cell fate control," said Run Shen, Ph.D., Postdoctoral Research Associate in the Xie Lab and lead author on the paper. "Many protein translation initiation factors have been reported to be unregulated in different human cancer tissues, so our study may help to understand how translational initiation factors participate in stem cell misregulation and the development of tumors."

"Our studies have established the role of BAM as a protein translational repressor using biochemical and genetic tests," said Ting Xie, Ph.D., Investigator and senior author on the paper. "Translational control is very important in regulating gene expression. Many genes critical for stem cell development in the fruit fly germline are suggested to be translational regulators, but their exact roles have not been ca
'/>"/>

Contact: Marie Jennings
mfj@stowers.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research uncovers clues to virus-cancer link
2. New genomic technique uncovers coral transcriptome
3. Skin cancer study uncovers new tumor suppressor gene
4. Research uncovers promising target to treat chronic abdominal pain
5. Research uncovers surprising lion stronghold in war-torn central Africa
6. University of Leicester archaeologist uncovers evidence of ancient chemical warfare
7. Case Western Reserve University uncovers genetic basis for some birth defects
8. Research uncovers new steps on pathway to enlarged heart
9. Computational biochemist uncovers a molecular clue to evolution
10. University of Miami scientist uncovers miscalculation in geological undersea record
11. Epigenetic research uncovers new targets for modification enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2, 2015 Fingerprint Cards (FPC) ... FPC1025 from the distributor World Peace Industrial Group (WPI), ... 2015 although the major part of the shipments will ... used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK ...
(Date:4/1/2015)... , April 1, 2015   Medisafe ™, the ... users across iOS and Android ... integrating biofeedback into the platform to allow patients to ... For the first time, patients will be able to ... dose impacts important biometrics, such as glucose levels and ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... study of more than 68,000 infants published in this ... Rotateq demonstrated that it can safely prevent 98 percent ... account for 2 million hospital visits and 500,000 pediatric ... largest pre-licensure vaccine clinical trials ever conducted worldwide, research ...
... against the Epstein-Barr virus, the virus that most often ... sclerosis 15 to 20 years later, according to a ... June 2006 print issue of Archives of Neurology, one ... that external factors may influence the risk for multiple ...
... called statins do not appear to reduce the incidence ... of previous studies in the January 4 issue of ... the risk of developing cancer, the authors provide as ... been studied in numerous large-scale, randomized, active- or placebo-controlled ...
Cached Biology News:New vaccine for condition that kills 500,000 children a year 2New vaccine for condition that kills 500,000 children a year 3Epstein-Barr virus may be associated with multiple sclerosis 2Statins have neutral effect on risk of cancer 2
(Date:4/16/2015)... Japan , April 16, 2015  Center ... University and Takeda Pharmaceutical Company Limited (Takeda) announced ... clinical applications of induced pluripotent stem cells in ... disorders and cancer immunotherapy. The "Takeda-CiRA Joint Program ... expedite multiple research projects for drug discovery and ...
(Date:4/16/2015)... Proove Biosciences , Inc. is pleased to ... for the 2015 BIO International Convention. Hosted by the ... will take place June 15-18 at the Pennsylvania Convention ... contest, industry leaders will be voting for companies they ... community voting period began on April 14, 2015 and ...
(Date:4/16/2015)... 16, 2015 OncoTAb, Inc., ... (UNC Charlotte) spin-out company, announced today the appointment ... M.D., as Chief Operating Officer (COO). Cooper brings ... in developing clinical diagnostic and biotechnology platforms in ... , Cooper’s extensive career transcends the field of ...
(Date:4/16/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... venture with G-treeBNT (ReGenTree LLC) has retained Ora, ... for the orphan disorder, neurotrophic keratopathy (NK), and ... syndrome (DES) in the U.S.  Both trials will ... year.  Each of these eye disorders was being ...
Breaking Biology Technology:CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3OncoTAb Names Dr. David L. Cooper as COO 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5
... a Tool to Make Soyfoods Even HealthierST. LOUIS, March ... healthcare professionals believe soy to be beneficial to the ... method to make food products such as soyfoods even ... Biotechnology Awareness & Attitude Survey - sponsored by ...
... cell line manufacturing, Selexis is now offering a ... drugs with added characterization servicesGENEVA, March 31 ... and services for the rapid development of high-performance ... offering focusing on the biosimilar market segment. ...
... March 31 Sigma-Aldrich (Nasdaq: ... quality services and oligonucleotides to Gene Oracle, an innovative ... agreement, Sigma-Aldrich will be the exclusive supplier of custom ... engage in co-marketing efforts to promote the GeneIOS system ...
Cached Biology Technology:Nearly 70 Percent of Health Professionals Support Biotechnology's Use in Food Products 2Nearly 70 Percent of Health Professionals Support Biotechnology's Use in Food Products 3Selexis Launches Biosimilar Cell Line Development Program 2Sigma-Aldrich Enters Exclusive Supply Agreement With Gene Oracle to Leverage Its Unique GeneIOS Gene Synthesis Platform 2Sigma-Aldrich Enters Exclusive Supply Agreement With Gene Oracle to Leverage Its Unique GeneIOS Gene Synthesis Platform 3
Mouse Anti-Lamin B...
Hybridization Buffer 3.6 ml...
Chicken polyclonal to Thaumatin 2 ( Abpromise for all tested applications). Antigen: Full length Thaumatin 2...
Proteinase K Buffer 3.9 ml...
Biology Products: