Navigation Links
Xie Lab characterizes niche control of stem cell function
Date:1/10/2008

The Stowers Institutes Xie Lab has published findings that begin to characterize the poorly understood interaction among stem cells within their cellular microenvironment, called a niche.

The findings appear in todays issue of Cell Stem Cell.

The Xie Lab demonstrated that differentiation-defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out-compete normal stem cells for a position in the niche. They do so by invading the niche space of neighboring GSCs and gradually pushing them out of the niche by increasing the cellular response to the adhesion molecule E-cadherin.

Furthermore, the team found that mutant GSC competition requires both E-cadherin and normal GSC division, and that different levels of E-cadherin expression can stimulate GSC competition.

We believe that this stem cell competition mechanism may explain why differentiated stem cells are displaced from the niche, said Zhigang Jin, Ph.D., Postdoctoral Research Associate and co-equal first author on the paper. We observed that stem cell competition serves as a quality control mechanism to ensure that only undifferentiated stem cells remain in the niche.

These findings offer important insights into the tight control of stem cell quality by the niche and how cancer stem cells might invade new niches for self-proliferation, said Ting Xie, Ph.D., Associate Investigator and senior author on the paper. Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long-term maintenance and generation of functional cells through augmented stem cell competition.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Circadian clock controls plant growth hormone
2. Key to out-of-control immune response in lung injury found
3. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
4. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
5. Controlling for size may also prevent cancer
6. UT Southwestern researchers identify hundreds of genes controlling female fertility
7. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
8. Doctors learn to control their own brains pain responses to better treat patients
9. New hope for horse lovers as effective control for killer ragwort is proposed
10. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
11. How does the opioid system control pain, reward and addictive behavior?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2016)... MINNETONKA, Minn. , Nov. 22, 2016   ... that supports the entire spectrum of clinical research, is ... by Medical LiveWire Healthcare and Life Sciences Awards ... This award caps off an unprecedented year of recognition ... clinical trials for over 15 years. iMedNet ...
(Date:11/17/2016)... 2016  AIC announces that it has just released a new white paper authored ... scale-out plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system ...
(Date:11/14/2016)...  xG Technology, Inc. ("xG" or the "Company") (Nasdaq: ... for use in challenging operating environments, announced its results ... will hold a conference call to discuss these results ... (details below). Key Recent Accomplishments ... agreement to acquire Vislink Communication Systems. The purchase is ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... ... 09, 2016 , ... There’s a winning streak at Voxx Analytics: the tech ... after winning the award last year as well. Employees nominate their companies for the ... Vesely pointed to the tech company’s upbeat environment as a reason. “We don’t answer ...
(Date:12/9/2016)... ... ... Aditya Humad, Acting CFO of AxioMed and Managing Partner of KICVentures, is pleased ... now gaining interest from Silicon Valley. “It was satisfying to complete the due diligence ... that, “We expect interest to continue to rise as AxioMed completes its cleanroom assembly ...
(Date:12/9/2016)... , Dec. 9, 2016  A platform of ... are moving one step closer to becoming viable ... OrthoMend Research, Inc., a start-up company from ... exclusive license for these novel absorbable bone fixation ... them for commercial use. The company has leased ...
(Date:12/9/2016)... , Dec. 9, 2016 /PRNewswire/ - Portage Biotech ... Exchange: PBT.U), is pleased to announce that Biohaven has ... New Haven, Connecticut (PRWEB) Dec 9, ... or "Biohaven") announced today that the U.S. Food and ... designation request covering its drug candidate BHV-0223, an orally ...
Breaking Biology Technology: