Navigation Links
Xie Lab characterizes niche control of stem cell function
Date:1/10/2008

The Stowers Institutes Xie Lab has published findings that begin to characterize the poorly understood interaction among stem cells within their cellular microenvironment, called a niche.

The findings appear in todays issue of Cell Stem Cell.

The Xie Lab demonstrated that differentiation-defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out-compete normal stem cells for a position in the niche. They do so by invading the niche space of neighboring GSCs and gradually pushing them out of the niche by increasing the cellular response to the adhesion molecule E-cadherin.

Furthermore, the team found that mutant GSC competition requires both E-cadherin and normal GSC division, and that different levels of E-cadherin expression can stimulate GSC competition.

We believe that this stem cell competition mechanism may explain why differentiated stem cells are displaced from the niche, said Zhigang Jin, Ph.D., Postdoctoral Research Associate and co-equal first author on the paper. We observed that stem cell competition serves as a quality control mechanism to ensure that only undifferentiated stem cells remain in the niche.

These findings offer important insights into the tight control of stem cell quality by the niche and how cancer stem cells might invade new niches for self-proliferation, said Ting Xie, Ph.D., Associate Investigator and senior author on the paper. Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long-term maintenance and generation of functional cells through augmented stem cell competition.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Circadian clock controls plant growth hormone
2. Key to out-of-control immune response in lung injury found
3. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
4. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
5. Controlling for size may also prevent cancer
6. UT Southwestern researchers identify hundreds of genes controlling female fertility
7. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
8. Doctors learn to control their own brains pain responses to better treat patients
9. New hope for horse lovers as effective control for killer ragwort is proposed
10. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
11. How does the opioid system control pain, reward and addictive behavior?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 2, 2014 It is a great ... the appointment of the world-renowned Thoracic and Cardiovascular surgeon, ... Dr. Ginsburg, with over 34 years of ... Hospital and Good Samaritan Regional Medical Center. Dr. Ginsburg ... late 1980,s and is considered an expert in the ...
(Date:7/10/2014)... 3, 2014 Research and Markets ( ... "Global Gesture Recognition & Touch-Less Sensing (2D, ... 2020" report to their offering ... Recognition & Touch-Less Sensing Market to Grow Exponentially. ... while, but the companies were unable to leverage ...
(Date:7/10/2014)... , July 8, 2014 ... won a new design win (DW). An Asian OEM has ... for mass production start in August 2014.   ... smartphone OEM, which has a planned date for start of ... initial ramp order of SEK 5M, for delivery in the ...
Breaking Biology News(10 mins):Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... children to eat their fruit and vegetables. But once ... often go the way of Barbie dolls and power ... fruits past adolescence. , Fisetin, a naturally occurring flavonoid ... stimulates signaling pathways that enhance long-term memory, report researchers ...
... UT Southwestern Medical Center experts warn that packing on pounds ... Americans who have diabetes and don't even know it. ... a silent killer because its symptoms aren't sudden, but build ... maladies. , That's bad news for those with undiagnosed ...
... archaeon capable of fixing nitrogen at a surprisingly hot ... earliest lineages of organisms capable of nitrogen fixation, perhaps ... animals rely on to fix nitrogen. , The ... Science supports the notion that the gene needed to ...
Cached Biology News:A natural chemical found in strawberries boosts memory in healthy mice 2A natural chemical found in strawberries boosts memory in healthy mice 3Holiday gluttony can spell disaster for undiagnosed diabetics 2Microbe fixes nitrogen at a blistering 92 C 2Microbe fixes nitrogen at a blistering 92 C 3
(Date:7/10/2014)... Terascala, the industry leader in ... a former vice president of product management for Flexera ... of marketing. Terascala’s software when combined with leading compute ... highest performance and most reliable solutions for processing big ... channel expansion and broaden its product portfolio. His leadership ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- ... and interpretation, today announced an agreement with ... analytics for Lineagen,s NextStep Dx PLUS.  ... neurodevelopmental and neurological disorders, currently offers FirstStep ... (CMA) testing service used by healthcare providers ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... BALTIMORE, May 16, 2012  In an effort to voice ... diseases (PIDD), the Immune Deficiency Foundation (IDF) offered oral ... Drug Administration (FDA) public hearing on draft guidance of ... (Ig) therapies from the biosimilars pathways in order to ...
... 12, 2011, nearly fifteen years after she became paralyzed and ... thinking about moving her arm and hand to lift a ... That achievement is one of the advances in brain-computer interfaces ... 17 edition of the journal Nature by the ...
... CENTERVILLE, Mass., May 16, 2012  UV Flu Technologies, ... announce that it has signed a television joint venture ... for the filming of a 60 second commercial, along ... locally, regionally, and nationally, on a variety of television ...
Cached Biology Technology:Immune Deficiency Foundation Urges FDA To Exempt Immunoglobulin From Biosimilars Pathway 2People with paralysis control robotic arms to reach and grasp using brain computer interface 2People with paralysis control robotic arms to reach and grasp using brain computer interface 3People with paralysis control robotic arms to reach and grasp using brain computer interface 4People with paralysis control robotic arms to reach and grasp using brain computer interface 5UV Flu Technologies to Commence a National TV Advertising Campaign 2UV Flu Technologies to Commence a National TV Advertising Campaign 3
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
Tris-Hepes kit of BG-163 & BG-165 (order number BG-166)...
... Immunogen: Synthetic peptide derived from the ... protein. Specificity: Reacts with the ... Reactivity: Human Mouse (positive controls: WNT1-transfected ... lysates and mouse Mouse-1 cell lysates). ...
Biology Products: