Navigation Links
Xie Lab characterizes niche control of stem cell function

The Stowers Institutes Xie Lab has published findings that begin to characterize the poorly understood interaction among stem cells within their cellular microenvironment, called a niche.

The findings appear in todays issue of Cell Stem Cell.

The Xie Lab demonstrated that differentiation-defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out-compete normal stem cells for a position in the niche. They do so by invading the niche space of neighboring GSCs and gradually pushing them out of the niche by increasing the cellular response to the adhesion molecule E-cadherin.

Furthermore, the team found that mutant GSC competition requires both E-cadherin and normal GSC division, and that different levels of E-cadherin expression can stimulate GSC competition.

We believe that this stem cell competition mechanism may explain why differentiated stem cells are displaced from the niche, said Zhigang Jin, Ph.D., Postdoctoral Research Associate and co-equal first author on the paper. We observed that stem cell competition serves as a quality control mechanism to ensure that only undifferentiated stem cells remain in the niche.

These findings offer important insights into the tight control of stem cell quality by the niche and how cancer stem cells might invade new niches for self-proliferation, said Ting Xie, Ph.D., Associate Investigator and senior author on the paper. Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long-term maintenance and generation of functional cells through augmented stem cell competition.


Contact: Marie Jennings
Stowers Institute for Medical Research

Page: 1

Related biology news :

1. Circadian clock controls plant growth hormone
2. Key to out-of-control immune response in lung injury found
3. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
4. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
5. Controlling for size may also prevent cancer
6. UT Southwestern researchers identify hundreds of genes controlling female fertility
7. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
8. Doctors learn to control their own brains pain responses to better treat patients
9. New hope for horse lovers as effective control for killer ragwort is proposed
10. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
11. How does the opioid system control pain, reward and addictive behavior?
Post Your Comments:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
(Date:6/22/2016)... DIEGO , June 22, 2016 ... that will allow them to produce up to ... from one lot within one week. These high-quality, ... time laboriously preparing cells and spend more time ... possible through a proprietary, high-volume manufacturing process that ...
(Date:6/22/2016)... June 22, 2016  According to Kalorama Information, ... sequencing (NGS) market include significant efforts in automation ... More accessible and affordable sequencers, say the healthcare ... for consumables including sample prep materials.  The healthcare ... Sample Preparation for Next Generation Sequencing (NGS) , ...
Breaking Biology Technology: