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XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients
Date:9/22/2011

nd three culture assays to determine the assays' abilities to detect XMRV/P-MLVs. The study also checked for evidence of contamination with mouse DNA, because XMRV or its predecessors may be present in some mouse strains and cell lines.

In 2009, WPI researchers had reported a possible link between XMRV and chronic fatigue syndrome. In June 2010, the AABB, a nonprofit U.S. blood banking association, recommended that collection centers discourage people with chronic fatigue syndrome from donating blood.

However, within the last year, evidence emerged suggesting that contamination in the laboratory was potentially responsible for detection of XMRV in some blood samples from patients with chronic fatigue syndrome. To ensure that this did not compromise results in the new study, extensive efforts were undertaken to avoid laboratory contamination and contamination of samples.

The Blood Systems Research Institute, San Francisco, including Graham Simmons, Ph. D., the paper's lead author, compiled the blood samples and distributed them to participating laboratories. The following labs and investigators were responsible for testing the sample panels:

  • Abbott (Two labs: Molecular Laboratory and Diagnostic Laboratory) -- John Hackett Jr., Ning Tang
  • CDC -- William M. Switzer, Walid Heneine
  • FDA -- Indira K. Hewlett, Jiangqin Zhao
  • FDA -- Shyh-Ching Lo/ Harvey Alter, NIH Clinical Center, Bethesda, Md.
  • Gen-Probe, Inc. -- Jeffrey M. Linnen, Kui Gao
  • NCI -- Mary F. Kearney/John M. Coffin, Tufts University, Boston
  • NCI -- Francis W. Ruscetti
  • WPI -- Judy A. Mikovits, Max A. Pfost

W. Ian Lipkin, M.D., of Columbia University's Mailman School of Public Health, is currently leading a separate study that is testing fresh blood samples from 150 people living with chronic fatigue syndrome and 150 similar but healthy people. Through this effort, organizers will process, blind, and send samples to laborato
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Contact: NHLBI Communications Office
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NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

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