Navigation Links
X-rays reveal the self-defence mechanisms of bacteria
Date:9/14/2012

Many pathogenic bacteria are able to go into a dormant state by producing persister cells that are not susceptible to conventional antibiotics. This causes serious problems in the treatment of life-threatening diseases such as tuberculosis, where the presence of persister cells often leads to a resurgence of infection following medical treatment.

At the molecular level, the formation of persister cells is due to the presence of toxins that are produced by the bacteria themselves, and which enable them to enter the dormant state. During this hibernation period, the bacteria constantly regulate the amount of toxin at exactly the same level and thus maintain the dormant state.

In an article recently published in the American scientific journal Structure, the researchers at the Department of Molecular Biology and Genetics, Aarhus University, present new results that reveal the molecular details of the regulatory mechanism of toxins.

By isolating and crystallising the toxin molecules and their molecular companions the antitoxins and by subsequently exposing the crystals to strong X-rays, the research team (consisting of the two PhD students Andreas Bggild and Nicholas Sofos and Associate Professor Ditlev E. Brodersen) gained unique insight into how bacteria control the amount of toxin in the cell (illustrated in the info box).

The new findings can eventually lead to the development of entirely new forms of treatment of bacterial infections that work initially by blocking toxin function and production, and subsequently by using traditional antibiotics to fight the pathogenic bacteria.


'/>"/>
Contact: Ditlev E. Brodersen
deb@mb.au.dk
45-21-66-90-01
Aarhus University
Source:Eurekalert  

Page: 1

Related biology news :

1. Dental X-rays linked to common brain tumor
2. Study reveals how common gene mutation affects kids with autism spectrum disorders
3. Researchers reveal a chemo-resistant cancer stem cell as cancers Achilles heel
4. Influenza research: Can dynamic mapping reveal clues about seasonality?
5. Brainy beverage: Study reveals how green tea boosts brain cell production to aid memory
6. Research reveals contrasting consequences of a warmer Earth
7. Ancient genome reveals its secrets
8. Tracking shuttle exhaust reveals more information about atmospheric winds
9. Primate of the opera: What soprano singing apes on helium reveal about the human voice
10. Ancient fossils reveal how the mollusc got its teeth
11. Research reveals unique solution to gene regulation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
X-rays reveal the self-defence mechanisms of bacteria
(Date:10/16/2014)... October 16, 2014 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... technologies including Wocket™, the Smart Wallet, at the 13 ... is a leading global conference on the intersection of ... Mark Anderson , founder and publisher of the ...
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... The German Gauß-Allianz has admitted Johannes Gutenberg University ... the Rhineland-Palatinate science hub continues to maintain a ... computing. , "The acceptance of Johannes Gutenberg ... Gauß-Allianz is a milestone in the national and ... support. The state of Rhineland-Palatinate can be proud ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... This release is also available in Chinese ... (September 28, 2010) -- The second law of thermodynamics is ... its implicit existential crunch. The tendency of a closed systems ... removed is a popular, if not depressing, "things fall apart" ...
... MT. ROYAL, NJ (September 28, 2010) "Migraine feels ... face," says author Andrew Levy in his interview on the ... of Our Heads". "It,s a metaphysical crisis." In the ... his personal experience with managing the pain of migraine, how ...
... (Sept. 28, 2010) -- A new book, RNA ... reviews our understanding of two RNA worlds: the primordial RNA ... and biocatalyst; and the contemporary RNA world, in which mRNA, ... operate. "[T]he plasticity of RNA stemming from ...
Cached Biology News:Tiny generators turn waste heat into power 2American Migraine Foundation launches new podcast series 2New book reviews ancient and modern worlds of RNA 2
(Date:10/20/2014)... -- GenVec, Inc. (NASDAQ: GNVC ) today announced the ... board of directors effective on October 24, 2014.   Dr. Horovitz ... its chairman from June 2006 to November 2013.  During his ... and Audit Committees of the board.  "We ... service to GenVec, and its stockholders," said Wayne T. ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Partners LLC, announced today that Ellen Teplitzky, an ... support for the pharmaceutical industry, has joined the ... of its legal services practice. NDA Partners ... expert witness and testimony, to top law firms ...
(Date:10/19/2014)... 2014 OCTOBER 20-22, 2014: ... ABIM will take place at the ... ABIM 2014 is now available at ... companies and organizations from all over the ... on the latest products and developments on ...
(Date:10/19/2014)... October 19, 2014 The Asian Automatic ... Asian with analysis and forecast of revenue. The Automatic ... to around $463.9 million by 2018, at a developing ... through the TOC of the Asian Automatic patient billing ... provided. This also provides a glimpse of the segmentation ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Pharmos Corporation,(Nasdaq: PARS ) announced today that ... from the Company., Mr. Rubino joined Pharmos ... acquisition and the subsequent integration of Vela,Pharmaceuticals completed ... has been focused on key business development priorities ...
... Synthetech, Inc. (OTC,Bulletin Board: NZYM) has earned ... outstanding accomplishments in environmental, health,safety and security ... by,the Synthetic Organic Chemical Manufacturers Association (SOCMA) ... awards are highly,regarded and demonstrate Synthetech,s level ...
... Dec. 18 January 1, 2008 will mark the,ritualistic day ... The New,Year also brings added pressure to smokers as January ... For those resolving to make 2008 the start of a ... Laser Therapy,provided by Achieve Laser, is quickly becoming a very ...
Cached Biology Technology:Pharmos Corporation Announces President & COO Alan L. Rubino to Leave Company 2Synthetech Earns National Recognition for Performance Improvement Program 2Synthetech Earns National Recognition for Performance Improvement Program 3Laser Therapy Gives Smokers Hope for Successful New Year's Resolution 2
... SYBR Safe DNA gel stain was developed ... than ethidium bromide for staining DNA in agarose ... only less mutagenic than ethidium bromide but SYBR ... of ethidium bromide. SYBR Safe stain comes as ...
... Service enables scientists who do not have access ... to have their biological samples tested for the ... easy as 1-2-3 Chose the analytes ... from the S&S antibody menu. Send your ...
... I nucleic acid gel stain is an ... bright fluorescence when bound to dsDNA and low ... dsDNA in gels using laser scanners or standard ... has also found uses in capillary electrophoresis, real-time ...
... stain has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... nucleic gel acid stain has also found ... bandshift assays. One mL stains 100 minigels. A ...
Biology Products: