Navigation Links
X-rays reveal the self-defence mechanisms of bacteria
Date:9/14/2012

Many pathogenic bacteria are able to go into a dormant state by producing persister cells that are not susceptible to conventional antibiotics. This causes serious problems in the treatment of life-threatening diseases such as tuberculosis, where the presence of persister cells often leads to a resurgence of infection following medical treatment.

At the molecular level, the formation of persister cells is due to the presence of toxins that are produced by the bacteria themselves, and which enable them to enter the dormant state. During this hibernation period, the bacteria constantly regulate the amount of toxin at exactly the same level and thus maintain the dormant state.

In an article recently published in the American scientific journal Structure, the researchers at the Department of Molecular Biology and Genetics, Aarhus University, present new results that reveal the molecular details of the regulatory mechanism of toxins.

By isolating and crystallising the toxin molecules and their molecular companions the antitoxins and by subsequently exposing the crystals to strong X-rays, the research team (consisting of the two PhD students Andreas Bggild and Nicholas Sofos and Associate Professor Ditlev E. Brodersen) gained unique insight into how bacteria control the amount of toxin in the cell (illustrated in the info box).

The new findings can eventually lead to the development of entirely new forms of treatment of bacterial infections that work initially by blocking toxin function and production, and subsequently by using traditional antibiotics to fight the pathogenic bacteria.


'/>"/>
Contact: Ditlev E. Brodersen
deb@mb.au.dk
45-21-66-90-01
Aarhus University
Source:Eurekalert  

Page: 1

Related biology news :

1. Dental X-rays linked to common brain tumor
2. Study reveals how common gene mutation affects kids with autism spectrum disorders
3. Researchers reveal a chemo-resistant cancer stem cell as cancers Achilles heel
4. Influenza research: Can dynamic mapping reveal clues about seasonality?
5. Brainy beverage: Study reveals how green tea boosts brain cell production to aid memory
6. Research reveals contrasting consequences of a warmer Earth
7. Ancient genome reveals its secrets
8. Tracking shuttle exhaust reveals more information about atmospheric winds
9. Primate of the opera: What soprano singing apes on helium reveal about the human voice
10. Ancient fossils reveal how the mollusc got its teeth
11. Research reveals unique solution to gene regulation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
X-rays reveal the self-defence mechanisms of bacteria
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
(Date:3/20/2017)... ALLENTOWN, Pa. , March 20, 2017 ... PD 2.0 personal spirometer and Wellness Management System (WMS), ... Founded in 2010, PMD Healthcare is a ... Company with a mission dedicated to creating innovative solutions ... of life. With that intent focus, PMD developed the ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... Linda, Ca (PRWEB) , ... April 20, 2017 ... ... University Virtual Event , this new webinar will explore challenging patient cases when ... admitted to the hospital, there may be a need for bridging parental anticoagulation ...
(Date:4/20/2017)...  Eli Lilly and Company (NYSE: LLY ... the prevention of migraine at the American Academy of ... 22-28, 2017, in Boston . ... including safety and patient outcomes data for galcanezumab in ... in monthly migraine headache days among patients with episodic ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... scientific and clinical research community’s growing body of knowledge during its Eighth ... Gracie Theatre and the adjacent Darling Atrium. During the event, undergraduates, graduate students, ...
(Date:4/20/2017)... LAVAL, QC , April 20, 2017 /PRNewswire/ - Prometic Life ... today presented new results at the International Liver Congress ("ILC") ... Liver ("EASL") in Amsterdam on the ... in a mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, ...
Breaking Biology Technology: