Navigation Links
X-ray laser helps slay parasite that causes sleeping sickness
Date:12/5/2012

An international team of scientists, using the world's most powerful X-ray laser, has revealed the three dimensional structure of a key enzyme that enables the single-celled parasite that causes African trypanosomiasis (or sleeping sickness) in humans.

With the elucidation of the 3D structure of the cathepsin B enzyme, it will be possible to design new drugs to inhibit the parasite (Trypanosoma brucei) that causes sleeping sickness, leaving the infected human unharmed.

The research team, including several ASU scientists, is led by the German Electron Synchrotron (DESY) scientist Henry Chapman from the Center of Free-Electron Laser Science (CFEL), professor Christian Betzel from the University of Hamburg and Lars Redecke from the SIAS joint Junior Research Group at the Universities of Hamburg and Lbeck. They report their findings this week in Science.

"This is the first new biological structure solved with a free-electron laser," said Chapman of the development.

"These images of an enzyme, which is a drug target for sleeping sickness, are the first results from our new 'diffract-then-destroy' snapshot X-ray laser method to show new biological structures which have not been seen before," explained John Spence, ASU Regents' Professor of Physics. "The work was led by the DESY group and used the Linac Coherent Light Source at the U.S. Department of Energy's SLAC National Accelerator Laboratory."

Transferred to its mammalian host by the bite of the tsetse fly, the effects of the parasite are almost always fatal if treatment is not received. The sleeping sickness parasite threatens more than 60 million people in sub-Saharan Africa and annually kills an estimated 30,000 people. Current drug treatments are not well tolerated, cause serious side effects and the parasites are becoming increasingly drug resistant.

"This paper is so exciting as it is based on nanocrystals grown by the groups at DES
'/>"/>

Contact: Jenny Green
jenny.green@asu.edu
480-965-1430
Arizona State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study provides recipe for supercharging atoms with X-ray laser
2. X-rays reveal the self-defence mechanisms of bacteria
3. Low-cost carbon capture gets X-rayed
4. Speed and power of X-ray laser helps unlock molecular mysteries
5. Stanford-SLAC team uses X-ray imaging to observe running batteries in action
6. Dental X-rays linked to common brain tumor
7. CMU and CTC to develop robotic laser system to strip paint from aircraft
8. Laser-powered needle promises pain-free injections
9. The laser beam as a 3-D painter
10. University of Tennessee Space Institute researchers develop laser technology to fight cancer
11. LAMIS -- a green chemistry alternative for laser spectroscopy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
X-ray laser helps slay parasite that causes sleeping sickness
(Date:12/17/2014)... fundamentally transforming the travel experience and nowhere is this ... decade, ePassports, biometric readers, and secure document scanners have ... via eGates and Automated Passport Control (APC) Kiosks at ... across the globe. According to ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... their offering. One major trend emerging ... advances in technology, it is important to upgrade biometric ...
(Date:12/11/2014)... 2014  That blood pressure plays a role in human health ... medical term for high blood pressure – was first described ... cuff that,s used in measuring blood pressure was invented in ... about hypertension, its triggers and its effects. In fact, recent ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... storage and use of surplus blood samples taken from newborns ... explicit to non-existent, leaving many parents ill-informed about how their ... team led by a member of the Johns Hopkins Berman ... of Utah. A report on their analysis of the subject ...
... Delhi, India The Indian Government today released new tiger ... numbers have increased in the country that has half of ... tiger numbers in India at 1,706, up from 1,411 during ... an additional tiger reserve in the count, the Sundarbans, that ...
... been the leaders in the use of intra-arterial yttrium-90 ... cancer. Now, new results from a large multi-institutional study ... Y-90 than previously tried is safe, provides results when ... can be done on an outpatient basis. This study, ...
Cached Biology News:Most states unclear about storage, use of babies' blood samples, new study finds 2Most states unclear about storage, use of babies' blood samples, new study finds 3Most states unclear about storage, use of babies' blood samples, new study finds 4India releases tiger numbers as experts convene 2Interventional Radiology Y-90 Liver Cancer-busting Treatment: Safe, Fast, Extends Life 2Interventional Radiology Y-90 Liver Cancer-busting Treatment: Safe, Fast, Extends Life 3
(Date:1/23/2015)... , Jan. 23, 2015  Array BioPharma Inc. (NASDAQ: ... a definitive agreement with Novartis Pharma AG to acquire ... in Phase 3 development.  This agreement is conditional on the ... (GSK) on April 22, 2014, which are expected to close ...
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... The laboratory information management systems market is a rapidly ... advancements due to factors such as rising pressure to ... systems, and increasing government support for adoption of HCIT ... in the market focus on technological advancements to further ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2
... Cardium Therapeutics (NYSE Amex: CXM ) today announced ... U.S. Food and Drug Administration (FDA) seeking marketing clearance ... XL is an advanced wound care management medical ... for use by physicians in patients with topical wounds, ...
... , BENLYSTA(TM) Successful in Second Pivotal Clinical Trial ... (HGS) and GlaxoSmithKline (GSK) today announced positive results from ... trials of BENLYSTA(TM) (belimumab) for treating systemic lupus. ... shared at the 73rd Annual Scientific meeting of the ...
... , KENILWORTH, N.J., Oct. 30 /PRNewswire-FirstCall/ ... ) announced today the U.S. Food and Drug ... to the company,s supplemental Biologics License Application regarding ... of patients with stage III malignant melanoma after ...
Cached Biology Technology:Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds 2Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds 3Cardium Announces Plans to File FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Gel for Diabetic, Pressure and Venous Ulcers and Other Topical Wounds 4Promise of a New Lupus Treatment Is a Groundbreaking Achievement 2Promise of a New Lupus Treatment Is a Groundbreaking Achievement 3U.S. Food and Drug Administration Issues Complete Response Letter Regarding PEGINTRON(R) for Malignant Melanoma 2U.S. Food and Drug Administration Issues Complete Response Letter Regarding PEGINTRON(R) for Malignant Melanoma 3U.S. Food and Drug Administration Issues Complete Response Letter Regarding PEGINTRON(R) for Malignant Melanoma 4U.S. Food and Drug Administration Issues Complete Response Letter Regarding PEGINTRON(R) for Malignant Melanoma 5U.S. Food and Drug Administration Issues Complete Response Letter Regarding PEGINTRON(R) for Malignant Melanoma 6
...
...
... Specificity: This antibody recognizes murine ... cross-react with other related IRF ... with murine IRF7 protein was ... of the 293T cells transfected ...
...
Biology Products: