Navigation Links
X chromosome exposed
Date:5/29/2008

Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the EMBL-European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, have revealed new insights into how sex chromosomes are regulated. A chromatin modifying enzyme helps compensate for the fact that males have only one copy of the sex chromosome X, while females have two. The enzyme distinguishes between male and female sex chromosomes in fruit flies and binds to different locations on the male and female X chromosome, the scientists report in the current issue of the journal Cell. The evolutionarily conserved enzyme is also found in humans.

In species ranging from insects to humans, sex chromosomes, the famous X and Y, are responsible for determining gender. Females have two copies of the X chromosome while males have one X and one Y. This could mean that females produce twice as many proteins from the genes carried on the X chromosome as males. However, fruit flies compensate for the sex chromosome difference by doubling the activity of genes on the X chromosome in males a vital process called dosage compensation. Biologists already know that a molecular machine called the MSL complex achieves dosage compensation in flies, but it remains unclear how exactly it accomplishes its function.

Now researchers from the lab of Asifa Akhtar at EMBL and the groups of Nick Luscombe and Paul Bertone at EMBL-EBI have uncovered how one component of the MSL complex, an enzyme called MOF, ensures that the activity of only male X chromosome genes get ratcheted up. MOF relaxes the structure of chromatin tightly packaged DNA, to allow the transcription machinery to access genes on the DNA.

We were very surprised to find MOF bound not only to the X chromosome in males, but also to all the other chromosomes in the nucleus. This suggests the enzyme as a universal regulator of transcription that has evolved to play a specific role in dosage compensation, says
'/>"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
49-622-138-7452
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
2. Fungi can tell us about the origin of sex chromosomes
3. Workman Lab characterizes novel regulator of chromosome function
4. Bioclocks work by controlling chromosome coiling
5. X-effect: female chromosome confirmed a prime driver of speciation
6. Grant supports study of abnormal ring-shaped chromosomes
7. Penguins exposed to DDT from melting glaciers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ... 2015-2019"  report to their offering. ... advances in technology. With continuous advances in technology, ... the latest standard that meets the needs and ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... provider of scientific, technical and medical information products and ... study in Reproductive BioMedicine Online ... male couples and single men when using assisted reproduction ... single men using assisted reproduction assistance to have a ...
... an emerging treatment that aims to fight colorectal cancer ... the ESMO 15th World Congress on Gastrointestinal Cancer. ... called MGN1703 and suggest it may be possible to ... the treatment, reported Prof Hans-Joachim Schmoll from Martin Luther ...
... weeding out the bacteria that form the base of ... according to a new study. In climate change, ... atmospheric carbon dioxide levels and temperature rise globally, scientists ... which will perish in the environment of tomorrow. ...
Cached Biology News:Reproductive BioMedicine Online publishes study on assisted reproduction 2Immune-boosting colorectal cancer drug shows promise 2Greenhouse gas likely altering ocean foodchain 2
(Date:12/24/2014)... December 23, 2014 “Preparative & ... HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, ... & Agriculture) - Forecasts to 2019” provides a ... opportunities, current market trends, and strategies impacting the ... estimates and forecasts of the revenue and share ...
(Date:12/24/2014)... 23, 2014 On Friday, December ... 83, the Omnibus and Continuing Resolution Appropriations Act ... hydrocephalus a condition eligible to receive funding through ... by the Department of Defense (DoD). The Hydrocephalus ... on Capitol Hill, is celebrating this victory for ...
(Date:12/24/2014)... report expects global cell isolation and expansion market to ... carefully analyzed data about the vital drivers, restraints, trends, ... Copy of Report @ http://bit.ly/1yUxy0T , According ... will keep witnessing growth at an impressive CAGR during ... by rapid technological advancements, government funding and investments, and ...
(Date:12/24/2014)... 23, 2014 PharmaBoardroom,s new ... today and available for free download , digs deep ... and growth in the sector today. One area ... has been in developing a homegrown pharmaceutical manufacturing base, even ... still remains some way off. A cursory comparison with neighboring ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... SOMERSET, N.J., Oct. 4 Alfacell Corporation,(Nasdaq: ACEL ... chief financial officer and corporate secretary, will present an,overview ... PDT on,Oct. 11th, at BIO InvestorForum 2007 at the ... Webcast of the presentation will be available on,Alfacell,s Web ...
... Kendle (Nasdaq: KNDL ), a,leading, global full-service ... Operating Officer Christopher C. Bergen,will participate in the ... held at The Carlton on Madison Avenue in ... scheduled for Monday, Oct. 8 at,2:15 p.m. Eastern ...
... announced today that it has entered into a ... Cancer (IRIC) of the Universite de,Montreal. This collaboration, ... by Sigma-Aldrich, will leverage Sigma,s RNA,Interference (RNAi) technologies ... Sigma-Aldrich and the Universite de Montreal have ...
Cached Biology Technology:Alfacell to Present at BIO InvestorForum 2007 2Kendle to Present at the Natixis Bleichroeder Hidden Gems Conference 2Sigma-Aldrich and the Universite de Montreal Establish Collaboration for RNA Interference Studies 2
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Biology Products: