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Wyss Institute's technology translation engine launches 'Organs-on-Chips' company
Date:7/28/2014

lopment from demonstration of the first functional prototypes to multiple human Organs-on-Chips that can be integrated on a common instrument platform also speaks to the Institute's ability to translate academic innovation into commercially valuable technologies in a big and meaningful way. "We took a game-changing advance in microengineering made in our academic lab, and in just a handful of years, turned it into a technology that is now poised to have a major impact on society. The Wyss Institute is the only place this could happen," added Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences.

Since their 2010 publication on the human breathing lung-on-a-chip in Science, and with grant support from the Defense Advanced Research Projects Agency (DARPA), Food and Drug Administration (FDA) and National Institutes of Health (NIH), Ingber and his team have developed more than ten different Organs-on-Chip models, including chips that mimic liver, gut, kidney and bone marrow. The DARPA effort also has supported the engineering of the instrument that automates chip operations and fluidically links the different organs-on-chips together to more closely mimic whole body physiology, while permitting high resolution imaging and molecular analysis.

The transition of the Organs-on-Chips technology to a startup was enabled by the Wyss Institute's unique technology translation model, which takes lead high-value technologies that emerge from Wyss faculty efforts, and de-risks them both technically and commercially to increase their likelihood for commercial success. Through numerous collaborations with industry, the Wyss Institute team refined their technology, and validated it for market need and impact by testing existing drugs and modeling various human diseases on-chip. And with an eye towards c
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Contact: Mary Tolikas
mary.tolikas@wyss.harvard.edu
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

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