Navigation Links
Worm genes KO'd
Date:4/25/2010

SALT LAKE CITY, April 25, 2010 Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing knockout mice. Kent Golic found a way to cripple fruit fly genes. Now, biologist Erik Jorgensen and colleagues have devised a procedure for knocking out genes in nematode worms.

"We developed a method that allows us to walk through the worm genome and determine the function of each gene, and thereby infer the function of these genes in humans," says Jorgensen, a biology professor, senior author of a new study outlining the technique, and an investigator with the Howard Hughes Medical Institute.

The study shows how a transposon or "jumping gene" can be used to delete specific genes from the 1-millimeter-long nematode worm, Caenorhabditis elegans. It was scheduled for online publication Sunday, April 25 in the journal Nature Methods.

"We are trying to understand how genes work and are regulated, and the easiest way to do that is to use a simple organism," says University of Utah postdoctoral fellow Christian Frkjr-Jensen, the study's first author. "The amazing thing is that cellular processes in a lowly worm are similar to the biology in humans. We've made it much easier and faster to change the genetic blueprint of a simple worm so we can study and understand how genes are regulated."

Jorgensen adds: "We want to know what human genes do because they allow us to do all the wonderful things we do run, speak, live and understand what goes wrong in genetic diseases and how we can possibly treat them."

Capecchi, a distinguished professor of human genetics, shared the 2007 Nobel Prize in Physiology or Medicine with two other researchers who independently developed gene targeting in mice in the 1980s. Golic, a professor of biology, published his key papers on targe
'/>"/>

Contact: Lee Siegel
leesiegel@ucomm.utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worm genes KO'd
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ... robust – with the clinical data to back it ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for ... Medicine. Funding for this $50 million capital project is ... publicly launched next summer. The medical ... series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine ... with plans to be ready to welcome medical students ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold ... chromosome 16 that substantially increases risk for schizophrenia. ... number variant (CNV). CNVs are areas of the genome where ... CNV is located in a region referred to by scientists ...
... Calif., Oct. 23 GenVault Corporation, the leader in ... identification, today announced that David Wellis, Ph.D., GenVault,s President ... Conference taking place on October 26th and 27th in ... will provide an overview of the company together with ...
... Among the many changes in the ocean is the expansion ... dead zones, which affect the processes by which carbon is ... activities that impact the rate and magnitude of ocean carbon ... known about the metabolism of OMZ microbes and how they ...
Cached Biology News:CSHL-led team discovers rare mutation dramatically increasing schizophrenia risk 2GenVault Corporation to Present at the 2009 BIOCOM Investor Conference 2Model microbial community for studying expanding dead zones characterized 2Model microbial community for studying expanding dead zones characterized 3
(Date:12/24/2014)... and NEW YORK , Dec. ... its open-label pilot study of mazindol in children with ... and Therapy in December 2014 . ... in children with attention deficit/hyperactivity disorder" ( Konofal et ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows that ...
(Date:12/22/2014)... , Dec. 22, 2014  Alternative Energy & ... it has signed a letter of intent to ... developed and patented a nanotechnology-based development platform used ... that enable rapid on-site collection and testing to ... health issues in an immediate, non-invasive and cost-effective ...
(Date:12/22/2014)... Illinois (PRWEB) December 22, 2014 ITRA ... tenants and occupiers of commercial real estate, has further ... new offices in Perth and Brisbane, Western Australia, reports ... of directors. , ITRA Global / ACORPP (Australian ... totally independent consultancy company providing property services to a ...
(Date:12/19/2014)... 19, 2014 BioPlus Specialty Pharmacy ... announces the promotion of Nick Maroulis, Pharm.D. to the ... Services. , In this position, Dr. Maroulis will ... managing the directors of our multi-site pharmacies as the ... 1997 and during that time he has served in ...
Breaking Biology Technology:Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... , PRINCETON, N.J. and SAN DIEGO, July ... company committed to research and product discovery for the ... pharmacokinetic data and results from two Phase I pharmacokinetic ... the treatment of HIV. These data suggest that ...
... , , ROCKVILLE, Md., July 21 ... appointment of John J. Trizzino as Senior Vice President, International ... Trizzino will report directly to Dr. Rahul Singhvi, Novavax,s President ... managing the company,s international alliances with pharmaceutical companies and all ...
... NEW YORK, July 21 ... AOB ), ("the Company" or "AOBO"), a pharmaceutical,company ... and,commercialization of a broad range of prescription and ... that AOBO was honorably elected as one of,the ...
Cached Biology Technology:Tobira Therapeutics Inc. Announces Phase I Data Demonstrating Pharmacokinetic Properties of TAK-652 for the Treatment of HIV 2Novavax Announces Appointment of John J. Trizzino as Senior Vice President, International and Government Alliances 2American Oriental Bioengineering Honorably Elected a Top 20 Most Competitive Public Pharmaceutical Company in China 2
Sf21 Insect Cells (Frozen) in Max-XP Medium...
... is used for conventional PCR and thermal ... personal thermal cycler, which features a 96-well ... tubes or plates, programmable time, temperature, and ... modes of temperature control. The system also ...
... ChipWriter Pro system with colony-picking capabilities, 110-120 ... array DNA, proteins, oligonucleotides, carbohydrates, lipids, and ... for microarray applications. This system can also ... as 300 micrometers in diameter and for ...
... Ciphergen's ProteinChip arrays have been developed ... biological samples. A variety of ProteinChip ... proteins according to their unique biochemical ... spots, allowing side-by-side sample comparison, and ...
Biology Products: