The study, published in the Journal of Experimental Medicine and featured in Nature's 'research highlights' today (Thursday), found that Muc5ac is also essential for the efficient expulsion from the gut of other types of worm that cause problems in humans. These include the hookworm, and the spiral threadworm. Together, these worms cause mortality and morbidity in up to one billion people across the globe.
Dr Sumaira Hasnain, the lead experimentalist on the project, added: "For the first time, we have discovered that a single component of the mucus barrier, the Muc5ac mucin, is essential for worm expulsion. Our research may help to identify who is and who isn't susceptible to parasitic worms, and it may eventually lead to new treatments for people with chronic worm infections."
|Contact: Aeron Haworth|
University of Manchester