Navigation Links
Worm discovery could help 1 billion people worldwide
Date:5/5/2011

Scientists have discovered why some people may be protected from harmful parasitic worms naturally while others cannot in what could lead to new therapies for up to one billion people worldwide.

Parasitic worms are a major cause of mortality and morbidity affecting up to a billion people, particularly in the Third World, as well as domestic pets and livestock across the globe.

Now, University of Manchester researchers have, for the first time, identified a key component of mucus found in the guts of humans and animals that is toxic to worms.

"These parasitic worms live in the gut, which is protected by a thick layer of mucus," explained Dr David Thornton, from the University's Wellcome Trust Centre for Cell Matrix Research. "The mucus barrier is not just slime, but a complex mixture of salts, water and large 'sugar-coated' proteins called mucins that give mucus its gellike properties.

"In order to be able to study these debilitating worm diseases, we have been using a mouse model in which we try to cure mice of the whipworm Trichuris muris. This worm is closely related to the human equivalent, Trichuris trichiura.

"We previously found that mice that were able to expel this whipworm from the gut made more mucus. Importantly, the mucus from these mice contained the mucin, Muc5ac. This mucin is rarely present in the gut, but when it is, it alters the physical properties of the mucus gel."

Co-lead on the study, Professor Richard Grencis, from the Faculty of Life Sciences, continued: "For this new research, we asked how important Muc5ac is during worm infection by using mice lacking the gene for Muc5ac. We found that mice genetically incapable of producing Muc5ac were unable to expel the worms, despite having a strong immune response against these parasites. This resulted in long-term infections.

"Furthermore, we discovered the reason for the importance of Muc5ac is that it is 'toxic' for the worms and damages their health."

The study, published in the Journal of Experimental Medicine and featured in Nature's 'research highlights' today (Thursday), found that Muc5ac is also essential for the efficient expulsion from the gut of other types of worm that cause problems in humans. These include the hookworm, and the spiral threadworm. Together, these worms cause mortality and morbidity in up to one billion people across the globe.

Dr Sumaira Hasnain, the lead experimentalist on the project, added: "For the first time, we have discovered that a single component of the mucus barrier, the Muc5ac mucin, is essential for worm expulsion. Our research may help to identify who is and who isn't susceptible to parasitic worms, and it may eventually lead to new treatments for people with chronic worm infections."


'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert  

Related biology news :

1. Chemical equator discovery will aid pollution mapping
2. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
3. Groundbreaking discovery may lead to stronger antibiotics
4. Discovery of natural compounds that could slow blood vessel growth
5. Nanoscopic screening process to speed drug discovery
6. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
7. New $11 million center to speed production of new compounds for drug discovery
8. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
9. New discovery may enhance MRI scans, lead to portable MRI machines
10. Kidney function discovery sheds light on genetic complexity of disease
11. Discovery of new gene associated with diabetes risk suggests link with body clock
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worm discovery could help 1 billion people worldwide
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... Windsor, Connecticut (PRWEB) , ... June 23, 2016 ... ... will introduce a new line of intelligent tools designed, tuned and optimized exclusively ... place September 12–17 in Chicago. The result of a collaboration among several companies ...
(Date:6/23/2016)... 23, 2016 ReportsnReports.com adds ... to its pharmaceuticals section with historic and forecast ... much more. Complete report on the ... profiling 15 companies and supported with 261 tables ... . The Global Cell Culture ...
(Date:6/22/2016)... -- Research and Markets has announced the addition of ... offering. The global biomarkers ... in 2013. The market is expected to grow at a five-year ... increasing from $50.6 billion in 2015 to $96.6 billion in 2020. ... period (2015 to 2020) are discussed. As well, new products approved ...
Breaking Biology Technology: