Navigation Links
Worm 'cell death' discovery could lead to new drugs for deadly parasite
Date:9/28/2011

a major source of human disease," Dr Fairlie said. "More than 2 billion people globally are at risk of parasitic worm infection, and we need to invest in the development of new drugs and vaccines, particularly as there are very few options currently available."

In the 1980s, scientists from the Institute and elsewhere discovered that defects in the cell death pathway were associated with cancer development. Dr Lee said the team are currently exploring the possibility that so-called 'BH3 mimetic' compounds such as ABT-737, discovered by biotechnology company Abbott, could also have a niche application for the treatment of parasitic worm diseases such as schistosomiasis. BH3 mimetics target the cell death pathway in humans and are currently being trialled as anti-cancer agents.

"The Bcl-2-regulated cell death pathway is currently being investigated as a therapeutic target for the treatment of some cancers," Dr Lee said. "We have found that a BH3-mimetic compound called ABT-737 binds to at least one schistosome pro-survival protein, suggesting it is feasible that BH3-like molecules could also be developed for treating schistosomiasis, and potentially other parasitic worm infections."

While the discovery leads to exciting new possibilities for the treatment of parasitic worm diseases, Dr Fairlie said there is still a lot to be understood about the cell death process in fluke worms before this becomes a reality. "Though we have found that this cell death pathway exists in the parasite, we don't yet know how important it is for the survival of the worm, or what the effect of drugs targeting the pathway will be. But we are excited about the possibility of developing an entirely new treatment strategy for schistosomiasis, which is a significant disease burden in developing countries," he said.


'/>"/>

Contact: Liz Williams
williams@wehi.edu.au
61-405-279-095
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research reveals how dynamic changes in methylation can determine cell fate
2. Elsevier congratulates editors of Stem Cells: Scientific Facts and Fiction upon receipt of awards
3. Cell dysfunction linked to obesity and metabolic disorders
4. Mice stem cells guided into myelinating cells by the trillions
5. Protein switches could turn cancer cells into tiny chemotherapy factories
6. Cellular origin of a rare form of breast cancer identified
7. Team creates genetic GPS system to comprehensively locate and track inhibitory nerve cells
8. Scientists turn back the clock on adult stem cells aging
9. Spiral constriction -- how dynamin mediates cellular nutrient uptake
10. The cellular intricacies of cystic fibrosis
11. Why carbon nanotubes spell trouble for cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Worm 'cell death' discovery could lead to new drugs for deadly parasite
(Date:1/22/2015)... January 22, 2015 , ... The European Patent Office to present a video retrospective ... nominations to be featured: Christofer Toumazou and Sophie ... finalists and winners of the Award   Starting on ...
(Date:1/22/2015)... has launched its new NXG series of time clocks with ... higher standard for collecting attendance and labor data and complements ... touch screen interface and seamless connection to cloud-based iSolved, the ... for the small to mid-size employer. The G2 ...
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) has ... Watermarking and Fingerprinting Markets" report to their ... This insight provides an overview of ... Watermarking aims to control and monitor piracy by ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... before. Whether it,s the death of a physically fit high school ... woman gardening in the middle of the day in July, heat ... treatment beyond submersion in ice water or the application of ice ... But, in a new study published today in the journal ...
... The decade from 2000 to 2009 was the warmest ... studies have shown evidence of changes in mountain plant ... yet taken a continental-scale view of the situation ... of mountain vegetation to climate change," scheduled for Advance ...
... this month, Biology of Reproduction is shifting its ... in Press production will remain unchanged for the time ... www.biolreprod.org as they are completed, rather than being ... the versions of record. At the end of each month, ...
Cached Biology News:'Couch potato pill' might stop heat stroke too 2'Couch potato pill' might stop heat stroke too 3European mountain vegetation shows effects of warmer climate 2
(Date:1/23/2015)... 2015  Array BioPharma Inc. (NASDAQ: ARRY ) ... with Novartis Pharma AG to acquire worldwide rights to ... development.  This agreement is conditional on the closing of transactions ... 2014, which are expected to close in the first ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Shimadzu ... new UV-1280 multipurpose UV-visible spectrophotometer. Offering wavelength scanning ... instrument is ideal for applications in a variety ... science. , The user-friendly UV-1280 enables intuitive operation, ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... January 22, 2015 Protocol Networks brings ... growing team of brand-neutral, independent consultants, Protocol Networks has ... explained that over the years, his company has attracted ... Town of Plainfield, as well as others. With the ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2
... ... Real-time in situ FTIR analysis has become a standard tool in the ... more thorough understanding of reactions during the development and scale-up of chemical ... of Batch and Continuous Chemical Processes Using Real-Time In Situ FTIR Analytics ...
... Clarient, Inc. (Nasdaq: ... resource for pathologists, oncologists and the pharmaceutical industry, today reported ... September 30, 2009. Results included a 13 percent increase ... compared to the third quarter of 2008. Third quarter ...
... ... Physics and Biology are Natural Partners in the Fight Against Disorder. , ... (PRWEB) November 3, 2009 -- ... Cushion that naturally relieves osteoarthritis without causing unwanted side-effects, is now available online at ...
Cached Biology Technology:Development of Batch and Continuous Chemical Processes Using Real-Time In Situ FTIR Analytics as a Process Analytical Technology (PAT) Tool 2Clarient Reports 2009 Third Quarter; Nine Month Results 2Clarient Reports 2009 Third Quarter; Nine Month Results 3Clarient Reports 2009 Third Quarter; Nine Month Results 4Clarient Reports 2009 Third Quarter; Nine Month Results 5Clarient Reports 2009 Third Quarter; Nine Month Results 6Clarient Reports 2009 Third Quarter; Nine Month Results 7Clarient Reports 2009 Third Quarter; Nine Month Results 8Clarient Reports 2009 Third Quarter; Nine Month Results 9Clarient Reports 2009 Third Quarter; Nine Month Results 10Clarient Reports 2009 Third Quarter; Nine Month Results 11New Technology Now Available In Canada For Osteoarthritis 2
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... array sample elements. , , ,Includes: , , ... in PBS (10X): 50 ml , Streptavidin ... 8 packs , 10% Tween-20: 2 x 10 ... x 25 ml , SuperSignal West Pico Stable Peroxide: ...
... The Partec Cell Counter Analyser counts ... that the CCA detects only cells, so ... influence the results.,While passing through a 250 ... a fluorescence light signal which is used ...
... Clean and Accurate Results Laser Capture ... the sensitivity and accuracy of molecular assays ... types and multi-cellular structures isolated from whole ... to microdissection-developed in 1996 at the National ...
Biology Products: