Navigation Links
World's biggest heart model simulated at Université de Montréal

Montreal, January 18, 2008 Researchers from the Universit de Montral have used a supercomputer to conduct the largest-ever mathematical simulation of the electrical activity of a human heart a 2 billion element model to provide new insight into cardiac and other illnesses. Until recently, the worlds largest simulated hearts had a few million elements at most. The UdeM simulation was up to 1,000 times more detailed than previous models and will enable new scientific discoveries that would never have been possible otherwise.

The computer on which the simulation was performed, a 768-processor SGI Altix 4700, is the largest shared-memory computing system in Canada. Operated by the Rseau qubcois de calcul de haute performance (RQCHP), it is used by hundreds of Canadian researchers. Mark Potse and Alain Vinet, of the UdeMs Institute of Biomedical Engineering, routinely use 60 to 100 of these processors to run their simulations of the human heart. In late October, Potse and Vinet had the opportunity to use the entire SGI Altix system and its1.2TB of shared memory to solve the largest, most detailed heart model ever.

Two weeks to simulate full heartbeat

The researchers simulated five milliseconds of activation in a tissue block that included some properties of a real heart, such as fibre running in different directions. The simulation solved a system of two billion equations a dozen times. The test took two hours. A full heartbeat, Potse says, would take two weeks to simulate and his team cannot claim use of the entire supercomputer for such lengths yet. The purpose of the test was to show that when the next generation supercomputers becomes available, researchers will be able to use it effectively, said Vinet. This type of model is increasingly difficult to solve when it is larger. It was far from evident that this test was going to work.

With heart disease one of the leading causes of death in the Western world, discovering the electrical triggers of the various kinds of heart disease could lead to earlier diagnosis and new treatment breakthroughs. In order to understand what the mechanisms of the particular disease are, the heart must be modeled with enormous detail. Once disease mechanisms are fully understood, scientists will be able to devise the best drug or the best cure surgical or other remedies -- and doctors will be able to diagnose much more precisely. Without the use of computer models it can be hard to track the effects of a heart disease on the ECG.


Contact: S-J Desjardins
University of Montreal

Related biology news :

1. The best both of worlds -- how to have sex and survive
2. 390-million-year-old scorpion fossil -- biggest bug known
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. High blood pressure, low energy -- a recipe for heart failure
5. Human derived stem cells can repair rat hearts damaged by heart attack
6. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
7. Heart of Herschel to be presented to media
8. Minimally invasive heart surgery research wins NIH award
9. A step toward tissue-engineered heart structures for children
10. Research explains link between cholesterol and heart disease
11. Eating competence may lower risk of heart disease
Post Your Comments:
(Date:5/12/2016)... , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: