Navigation Links
World premiere in stem cell research in Montreal
Date:4/16/2009

A team from the Institute for Research in Immunology and Cancer (IRIC) at Universit de Montral has succeeded in producing a large quantity of laboratory stem cells from a small number of blood stem cells obtained from bone marrow. The multidisciplinary team, directed by Dr. Guy Sauvageau, thus took a giant step towards the development of a revolutionary treatment based on these stem cells. This worldwide first will advance stem cell research and could have major implications in several fields for which no treatment currently exists.

Every year in North America, nearly 4,000 people wait in vain for a bone marrow transplant due to the lack of compatible donors. It is known that a bone marrow stem cell transplant can reconstitute the recipient's bone marrow. The main difficulty is to obtain a sufficient number of compatible stem cells. Thanks to Dr. Sauvageau and his team, these patients will be able to obtain new bone marrow within the next few years. "It could be possible to envision transplants for all adults from existing umbilical cord blood banks. The stem cell content of these blood banks is currently too limited for large-scale use in adults," Dr. Sauvageau affirmed.

Organ transplants without side effects: the medicine of the future?

Currently, transplant recipients are condemned to take medications against rejection of the transplanted organ and suffer the side effects for the rest of their lives. However, "mouse studies exist, showing that bone marrow stem cells can prevent the rejection typically directed against solid organs," Dr. Sauvageau said.

Rejection occurs because the immune system cells manufactured by bone marrow attack the transplanted organ as if it were an invader. By extrapolation from laboratory studies, it is very likely that transplanting hematopoietic stem cells collected from the organ donor and developed in the laboratory could avoid rejection of this organ. This is why it is important to have large quantities of hematopoietic stem cells, so that compatible stem cells can be matched with the organ to be transplanted.

Using proteins to multiply stem cells

To produce large quantities of hematopoietic stem cells in the laboratory, Dr. Sauvageau's team identified 10 proteins out of 700 candidates. These 10 proteins are naturally present in hematopoietic stem cells and researchers can use each of them to force these cells to multiply in the laboratory. "The next step is to verify whether this also works in humans. Everything is already in place," Guy Sauvageau pointed out. These tests will be conducted at Montreal's Maisonneuve-Rosemont Hospital, one of the leading centres in Canada where stem cell transplants are performed. "If only one of the ten proteins allows hematopoietic stem cells to be multiplied in humans, we will be able to obtain the quantities of cells necessary to perform transplants. It will then be possible to say "mission accomplished"."

Researchers around the world are currently trying to harness the regenerative power of other types of stem cells to treat diseases such as Alzheimer's or diabetes. IRIC's research could also help them achieve their goal.

The work of Dr. Sauvageau's team has been funded by the Canadian Institutes of Health Research and the findings are being published today in the prestigious scientific journal Cell.


'/>"/>

Contact: Carolyne Lord
carolyne.lord@umontreal.ca
514-343-7282
University of Montreal
Source:Eurekalert

Related biology news :

1. Sensoring the World Wide Web
2. Genes from tiny algae shed light on big role managing carbon in worlds oceans
3. MIT: How you feel the world impacts how you see it
4. UC and partners awarded $23 million to transform discoveries into real-world health solutions
5. The fragility of the worlds coral is revealed through a study of the Northwestern Hawaiian Islands
6. Collaboration leads to success: Most powerful computer of its kind in western N.Y. available worldwide
7. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
8. CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda
9. 4,000-year-old coral beds among worlds oldest living things, prof says
10. New research reveals the earliest evidence for corn in the New World
11. A quarter of the worlds population depends on degrading land
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... ... Lady had been battling arthritis since the age of two and at ... owner Hannah sought the help of Dr Jeff Christiansen of Superior Veterinary Surgical ... and help with the pain of Lady’s arthritis. Dr Christiansen suggested that in conjunction ...
(Date:5/24/2016)... Mass. (PRWEB) , ... May 24, 2016 , ... ... heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester ... cells into engines of wound healing and tissue regeneration. , The novel method, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Last week, Callan Capital, an integrated wealth management ... The Future of San Diego Life Science event at the Estancia La Jolla Resort ... the event with speakers Dr. Rich Heyman, former CEO of Aragon and Seragon, and ...
(Date:5/23/2016)... ... , ... The need for blood donations in South Texas and across the nation is growing. ... Tissue Center, blood donations are on the decline. In fact, donations across the country are ... in South Texas in the last four years alone. , There is no substitute for ...
Breaking Biology Technology: